Generalized eruptive histiocytoma. A clinical, histologic, and ultrastructural study

Caputo, Ruggero

doi:10.1001/archderm.117.4.216

Cited by 24 publications

(12 citation statements)

References 25 publications

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“…1 MEDF must be differentiated from generalized eruptive histiocytoma (GEH), now called generalized eruptive histiocytosis, 16 which is a form of adult self-healing histiocytosis in healthy adults characterized by the symmetric eruption of hundreds of papules on the trunk and extremities, the spontaneous resolution of the lesions and the histological findings of a benign mononuclear histiocytic cell infiltrate. 17 Multiple dermatofibromas limited to one anatomic region are extremely rare. Multiple grouped lipid laden histiocytomas are described in the literature as palmoplantar 18 and periorbital.…”

Section: Discussionmentioning

confidence: 99%

Multiple clustered dermatofibroma: case report and review of the literature

Gershtenson¹,

Krunic²,

Chen³

2010

J Cutan Pathol

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The presence of multiple dermatofibromas is rare and is defined as more than 15 lesions. Multiple clustered dermatofibroma (MCDF) is a distinct entity with only 12 reported cases in the literature. MCDF occurs in healthy individuals of both sexes in the first to third decades on the lower half of the body and portends an excellent prognosis. On histology, MCDF is consistent with benign dermatofibromas. We report a 31-year-old healthy Hispanic woman with a 14-year history of slowly progressive MCDF located on her right hip initially misdiagnosed as dermatofibrosarcoma protuberans. We believe this case represents the 13th report of MCDF in the literature and the second from North America.

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Section: Discussionmentioning

confidence: 99%

Multiple clustered dermatofibroma: case report and review of the literature

Gershtenson¹,

Krunic²,

Chen³

2010

J Cutan Pathol

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“…Langerhans' cells are not present on electron microscopy. Giant cells are conspicuously absent, differentiating these lesions from those of juvenile xanthogranuloma (41,42).…”

Section: Generalized Eruptive Histiocytomamentioning

confidence: 92%

“…The ultimate goal is to compose a definitive set of electron microscopic criteria for classifying the syndromes. Table 1 reviews the ultrastmctural findings in the different histiocytoses (11,39,40,41,83,87).…”

Section: Ultrastructurementioning

confidence: 99%

Cutaneous Histiocytosis Syndromes

Roper

Spraker

1985

Pediatric Dermatology

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Cutaneous histiocytosis may take two principal forms. It is either a benign proliferative process or a relentless, progressive process with a poor prognosis. In histiocytic medullary reticulosis, histiocytes demonstrate nuclear atypia and the outcome is uniformly fatal. Benign cephalic histiocytosis X causes lesions similar to those of histiocytosis X, but Langerhans' cells are absent. In congenital self-healing histiocytosis X, the Letterer-Siwe-like cutaneous infiltrate contains Langerhans' cells, but the lesions heal spontaneously without treatment. The nodular cutaneous lesions of juvenile xanthogranuloma appear in infancy and resolve without treatment; however, the higher percentage (10%) of associated ocular lesions may lead to glaucoma and blindness. In histiocytosis X, the cutaneous lesions show a marked proliferation of Langerhans' cells, with prognosis dependent on the patient's age and the extent of organ dysfunction. Patients who survive the acute form of the disease may develop diabetes insipidus, growth retardation, pulmonary fibrosis, and biliary cirrhosis. A subtle immunologic defect has been identified in patients with histiocytosis X, yet the pathogenesis of the disease is still speculative. Familial disease occurring in early infancy should be differentiated from complete or partial immunodeficiency syndromes. Guidelines for evaluating patients with cutaneous histiocytosis are reviewed.

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“…Absence of internal involvement, no tendency o f the lesions to coalesce and sparing of cutaneous flexures are the main differential characteristics be tween the two diseases [7], Xanthogranuloma [8] is rare among adults and generally le sions are less numerous and show and evi dent tendency to spontaneously regress. Histiocytic syndrome like generalized erup tive histiocytoma [9] show xanthomization only as a secondary phenomenon. Among normolipemic xanthomatosis the diffuse normolipemic xanthom a planum [10] starts from the eyelids as a xanthelasma and then spreads to other parts of the body: lesions are macular or only slightly infiltrated and the condition [11] is often associated with multiple myeloma.…”

Section: Discussionmentioning

confidence: 99%

Papular Xanthoma

Bundino¹,

Zina²,

Aloi³

1988

Dermatology

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The 5th case of papular xanthoma is reported. This entity can be differentiated on the basis of clinical and histological features: normolipidemic, nonconfluent, eruptive xanthomas located on the face, trunk and mucous membranes with no internal involvement. Histologically there are foamy cells and Touton giant cells without an inflammatory or histiocytic component. Electron microscopy shows macrophages packed with free lipidic vacuoles and lacking specific markers.

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Generalized eruptive histiocytoma. A clinical, histologic, and ultrastructural study

Cited by 24 publications

References 25 publications

Multiple clustered dermatofibroma: case report and review of the literature

Multiple clustered dermatofibroma: case report and review of the literature

Cutaneous Histiocytosis Syndromes

Papular Xanthoma

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