Generalized eruptive histiocytosis

Seward, James L.; Malone, Janine C.; Callen, Jeffrey P.

doi:10.1016/s0190-9622(03)02789-0

Cited by 43 publications

(32 citation statements)

References 16 publications

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“…Letterer-Siwe disease is characterized by extensive involvement of the skin, liver, lungs, bone marrow, lymph nodes, spleen, and other organs. Other presentations include a generalized eruption of multiple symmetric lesions on the trunk and proximal extremities [71], a solitary lung nodule [72], and purpuric lesions reflective of extramedullary hematopoiesis (blueberry muffins baby) [73].…”

Section: Clinical Coursementioning

confidence: 99%

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Dendritic cell neoplasms: An overview

et al. 2007

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Dendritic cell neoplasms are rare tumors that are being recognized with increasing frequency. They were previously classified as lymphomas, sarcomas, or histiocytic neoplasms. The World Health Organization (WHO) classifies dendritic cell neoplasms into five groups: Langerhans' cell histiocytosis, Langerhans' cell sarcoma, Interdigitating dendritic cell sarcoma/tumor, Follicular dendritic cell sarcoma/tumor, and Dendritic cell sarcoma, not specified otherwise (Jaffe, World Health Organization classification of tumors 2001; 273–289). Recently, Pileri et al. provided a comprehensive immunohistochemical classification of histiocytic and dendritic cell tumors (Pileri et al., Histopathology 2002;59:161–167). In this article, a concise overview regarding the pathological, clinical, and therapeutic aspects of follicular dendritic, interdigitating dendritic, and Langerhans' cell tumors is presented. Am. J. Hematol. 82:924–928, 2007. © 2007 Wiley‐Liss, Inc.

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Section: Clinical Coursementioning

confidence: 99%

“…Outcomes have been variable depending on the extent of the disease [34,40] with some published data reporting a disease-free survival (DFS) reaching up to more than 3 years [25, 27,30,71]. Relapses tend to occur within 1 to 3 years [25, 27,48,49,52].…”

Section: Treatmentmentioning

confidence: 99%

Dendritic cell neoplasms: An overview

et al. 2007

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“…[1] GEH is included in Type IIa -reactive histiocytoses involving cells of dermal dendrocyte lineage. [1] GEH is a rare cutaneous histiocytosis that mainly affects adults, [1][2][3] although children with these disorders have been reported. [4][5][6] Ever since Winkelmann and Muller described cases of GEH in three patients in 1963, many cases have been reported.…”

Section: Discussionmentioning

confidence: 99%

Generalized eruptive histiocytosis mimicking leprosy

Kumar¹,

Nandini²,

Niveditha³

et al. 2011

Indian J Dermatol Venereol Leprol

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Generalized eruptive histiocytosis (GEH) is a rare cutaneous histiocytosis that mainly affects adults and presents with multiple symmetric papules on face, trunk, and proximal extremities. GEH is included in type IIa (histiocytes involving cells of dermal dendrocyte lineage) of histiocytic disorders. Clinical and pathological correlations are required for differentiating GEH from other histiocytic disorders and from lepromatous leprosy which clinically mimic GEH and is prevalent in India. We report a case of a middle-aged woman who presented with generalized asymptomatic papules and nodules and was treated for leprosy but was finally diagnosed to have GEH after clinical, histopathological, and immunohistochemical correlation. Furthermore, the newer lesions also showed features of progressive nodular histiocytosis.

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“…Clinically, GEH has a polymorphous cutaneous eruption, varying from reddish papules to yellowish and brownish lesions in older lesions, distributed in discrete or cluster lesions over the whole body; the clinical course is usually benign and selflimited (3,4). Benign cephalic histiocytosis is thought to be a localized variant of eruptive histiocytosis; however, elinical progression to GEH has been documented (5).…”

Section: Discussionmentioning

confidence: 99%