Generalized eruptive histiocytosis mimicking leprosy

Abstract

Generalized eruptive histiocytosis (GEH) is a rare cutaneous histiocytosis that mainly affects adults and presents with multiple symmetric papules on face, trunk, and proximal extremities. GEH is included in type IIa (histiocytes involving cells of dermal dendrocyte lineage) of histiocytic disorders. Clinical and pathological correlations are required for differentiating GEH from other histiocytic disorders and from lepromatous leprosy which clinically mimic GEH and is prevalent in India. We report a case of a middle-aged woman who presented with generalized asymptomatic papules and nodules and was treated for leprosy but was finally diagnosed to have GEH after clinical, histopathological, and immunohistochemical correlation. Furthermore, the newer lesions also showed features of progressive nodular histiocytosis.

Laryngeal involvement with fatal outcome in progressive nodular histiocytosis: A rare case report

“…Treatment of PNH is usually unsatisfactory. Treatment modalities such as cyclophosphamide,[10] vincristine,[11] prednisolone,[11] azathioprine,[12] 6-mercaptopurine[12], Psoralen plus UVA,[13] have been tried by previous authors without much improvement. Reddy et al .…”