Generalized hereditary gingival fibromatosis in a child: clinical, histopathological and therapeutic aspects

Cunha, John Lennon Silva; Ramos, Maria Alice Carvalho da Cruz; Regis, Débora Menezes; Sánchez‐Romero, Celeste; Andrade, Maria Eliane de; Bezerra, Bruno Torres; Albuquerque‐Júnior, Ricardo Luiz Cavalcanti de

doi:10.4322/acr.2020.140

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…(11)Although the gingival enlargement does not directly affect the alveolar bone, the gingival overgrowth can lead to the formation of pseudo-pockets and predispose to bacterial accumulation inducing tissue inflammation and subsequently lead to the development of periodontal disease with bone loss. (1,8) In our clinical case series, the gingival hyperplasia covered the teeth leading to dental malposition and retention as well as the formation of pseudo-pockets with accumulation of plaque in the second patient, which may explain the presence of inflammation. However, no periodontal disease or bone loss was noted.…”

Section: Fourth Casementioning

confidence: 79%

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Hereditary Gingival Fibromatosis: Clinical Cases and Literature Review

Mahad¹,

Haïtami²,

Adnane³

et al. 2021

IJAR

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Gingival fibromatosis (GF) is characterized by a slow and progressive proliferation that can affect the marginal and attached gingiva, or the inter-dental papillae. This condition can be localized or generalized, with varying degrees of severity.GF may develop in susceptible individuals as a side effect of systemic medications or as idiopathic gingival fibromatosis. It may also be related to hereditary factors and occurs as a non-syndromic hereditary gingival fibromatosis or as a part of a syndrome.Our aim is to describe trought four cases of hereditary gingival fibromatosis and a literature review the clinical features,etiopathogenesis, histopathological characteristics and treatment of this condition.

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Section: Fourth Casementioning

confidence: 79%

“…Grade III: enlargement covering three quarters or more of the crown. (8) All the cases reported above had a severity level of class 2 to 3.…”

Section: Fourth Casementioning

confidence: 92%

Hereditary Gingival Fibromatosis: Clinical Cases and Literature Review

Mahad¹,

Haïtami²,

Adnane³

et al. 2021

IJAR

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“…Las formas severas de HG causan problemas funcionales y de fonación, además, de problemas estéticos y psicológicos (1,2). La HG es de evolución lenta, progresiva, generalizada o localizada (3). La etiología de esta condición patológica no está bien establecida.…”

Section: Introductionunclassified

Diferencias fenotípicas de fibroblastos gingivales en sujetos con hiperplasia gingival idiopática frente a sujetos periodontalmente sanos: estudio piloto

Simancas-Escorcia,

Díaz–Caballero,

Vergara–Hernández

2021

Acta Odontol. Colomb.

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Objetivo: identificar, describir y diferenciar las características fenotípicas de los fibroblastos gingivales (FGs) en pacientes con hiperplasia gingival idiopática (HGI) e individuos periodontalmente sanos. Métodos: los FGs fueron aislados a partir de tejido gingival de individuos periodontalmente sanos (n=2) y pacientes con HGI (n=2). Los FGs se cultivaron en el medio DMEM (Dulbecco's Modified of Eagle Medium) a 37°C con 5% de CO2. La identificación y localización de la actina, vimentina y mitocondrias en FGs fue realizada y evaluada microscópicamente mediante inmunofluorescencia con anticuerpos monoclonales. La capacidad de migración de los FGs en los pacientes con HGI e individuos sanos también fue estudiada. Resultados: todos los FGs fueron mononucleares, fusiformes y con prolongaciones citoplasmáticas visibles. La faloidina permitió identificar una densa red de actina en los FGs de pacientes con HGI, contrariamente a los FGs de individuos periodontalmente sanos. La vimentina y mitocondrias fueron identificadas en los FGs de individuos sanos y pacientes con HGI sin ninguna alteración en su expresión y localización. La migración de la monocapa de los FGs indicó una actividad de migración celular importante en los FGs de los pacientes con HGI, en relación a los FGs de los individuos periodontalmente sanos. Conclusión: los FGs de pacientes con HGI conservan características fenotípicas celulares similares a los FGs de individuos periodontalmente sanos. Sin embargo, los FGs de pacientes con HGI simulan tener una mayor capacidad migratoria que amerita ser explorada en futuros trabajos de investigación.

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Challenges in Differential Diagnosis of Diffuse Gingival Enlargement: Report of Two Representative Cases and Literature Review

Papadopoulou,

Kouri,

Andreou

et al. 2024

Dentistry Journal

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Background/Objectives: The etiology of diffuse gingival enlargement is multifactorial, and the definitive diagnosis may be challenging. To highlight the nuances of the differential diagnosis, we present two cases of generalized gingival overgrowth and discuss the diagnostic dilemmas. Case description: In the first case, an 82-year-old male with a medical history of hypertension and prostatitis had a chief complaint of symptomatic oral lesions of a 20-day duration, accompanied by fever and loss of appetite. The clinical examination revealed diffusely enlarged, hemorrhagic, and focally ulcerative upper and lower gingiva, ecchymoses on the buccal mucosa, as well as bilateral cervical lymphadenitis. The histopathologic and immunohistochemical findings combined with the hematologic examination led to a final diagnosis of acute myeloid leukemia, and the patient was referred to a specialized hematology/oncology unit for further management. The second case was a 74-year-old female with a medical history of breast cancer (successfully managed in the past), type II diabetes mellitus, and cardiovascular disease, taking various medications. An intraoral examination revealed diffusely enlarged, erythematous, and hemorrhagic upper and lower gingiva. An incisional biopsy showed hyperplastic granulation and fibrous connective tissue with a predominantly chronic inflammatory infiltrate. Considering the patient’s medical history and current medications, the clinical and microscopic findings were in support of the diagnosis of drug-induced gingival overgrowth associated with calcium channel blocker (amlodipine), partially controlled diabetes serving as an additional predisposing factor. Gingivectomy and periodontal scaling, along with substitution of the offending medication, were curative, and better diabetic control was recommended. Conclusions: Diffuse gingival overgrowth may be caused by a variety of diverse conditions, ranging from an exuberant response to local factors, potentially exacerbated by hormonal influences (e.g., puberty or pregnancy), to drug side effects to genetic, systemic, or even neoplastic diseases. A careful evaluation of the medical and drug history and clinicopathologic correlation is essential for accurate diagnosis and appropriate management.

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Generalized hereditary gingival fibromatosis in a child: clinical, histopathological and therapeutic aspects

Cited by 4 publications

References 33 publications

Hereditary Gingival Fibromatosis: Clinical Cases and Literature Review

Hereditary Gingival Fibromatosis: Clinical Cases and Literature Review

Diferencias fenotípicas de fibroblastos gingivales en sujetos con hiperplasia gingival idiopática frente a sujetos periodontalmente sanos: estudio piloto

Challenges in Differential Diagnosis of Diffuse Gingival Enlargement: Report of Two Representative Cases and Literature Review

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