Generalized multinucleate cell angiohistiocytoma

Chang, Sung Nam; Kim, Hee Sung; Kim, Soo Chan; Yang, Woo Ick

doi:10.1016/s0190-9622(96)90659-3

Cited by 32 publications

(30 citation statements)

References 6 publications

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“…Rarely, there is involvement of the oral mucosa . Exceptionally, lesions have been reported in a disseminated or generalized distribution . When multiple, papules are usually grouped over the same area and are distributed in a random, annular, or linear pattern.…”

Section: Discussionmentioning

confidence: 99%

Multinucleate cell angiohistiocytoma with hypertrophic nerves

et al. 2013

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Multinucleate cell angiohistiocytoma (MCAH) represents a rare benign skin lesion characterized by multiple papules that are usually found on the distal extremities or face of middle-aged women. We report on a 60-year-old male with a history of monoclonal gammopathy and severe rheumatoid arthritis who had several asymptomatic red-to-livid papules grouped on the right side of his trunk. The lesions had been present for a few years and were gradually enlarging. Biopsies from three lesions showed a spectrum of changes consisting of a proliferation of small venules together with thickened collagen bundles and increased numbers of interstitial cells including bizarre, multinucleated giant cells. Immunohistochemically, the multinucleated cells were positive for vimentin and lysozyme while the interstitial cells expressed CD68, factor XIIIa and lysozyme. Interestingly, strikingly enlarged dermal nerves were seen in all the three biopsies and two of the biopsies showed an accompanying infiltrate of lymphocytes and plasma cells.

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Section: Discussionmentioning

confidence: 99%

Multinucleate cell angiohistiocytoma with hypertrophic nerves

et al. 2013

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“…Other less common locations include the eyelid, orbit, upper lip, and oral mucosa 2–4 . We found only one report of generalized MCAH 5 …”

Section: Discussionmentioning

confidence: 81%

Multiple papules on the trunk and extremities

Martí¹,

Monteagudo

Revert³

et al. 2013

Int J Dermatology

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“…3 MCAH may be clinically mistaken for Kaposi sarcoma, acroangiodermatitis, and a range of other conditions including fibrous histiocytoma, arthropod bite, and lupus erythematosus. 1,2 A generalized disseminated form has also been described.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 A generalized disseminated form has also been described. [1][2][3][4][5] An increased number of factor XIIIapositive dermal dendrocytic spindle cells and mast cells are also characteristic features. 2,4 MCAH is histologically characterized by dermal proliferation of small blood vessels associated with numerous multinucleated giant cells with often bizarre, angulated, and scalloped margins dispersed between the thickened collagen of the reticular dermis.…”

Section: Discussionmentioning

confidence: 99%