Generalized Trichophyton Rubrum Infection Associated With Systemic Lymphoblastoma

Chronic dermatophyte infections. I. Clinical and mycological features

“…However, certain features of the chronic dennatophyte infection have been established. It has been shown, for instance, that 'chronic' infections are often caused by Trichophyton rubrum (Hanifin, Ray & Lobitz, 1974;Kaaman, Petrini & Wasserman, 1979) and may be associated with atopy (Hanifin et al, 1974)5 diabetes mellitus (Mandel,i960), Cushing's syndrome (Nelson & McNiece,,i959) or lymphoma (Lewis, Hopper & Scott, 1953). However, the exact relationship between the underlying disease, the causative organism and the clinical patterri of infection on the one hand and treatment failure or the duration of infection on the other is still not clear.…”

Immune responses in patients with chronic Trichophyton rubrum infections

“…Unfortunately, the infection may become chronic and treatment unsatisfactory because of a total or partial lack of response to griseofulvin or because the organism can be re-isolated from lesions shortly after stopping therapy. In contrast, other dermatophyte infections, and in particular those caused by the zoophilic organisms, are often associated with marked infiammation and tend to respond well to treatment, re-infection being a rare occurrence.This difierence in behaviour between similar organisms has led dermatologists in the past to search for predisposing factors and there are now a number of reports of chronic T.rubrum infections in association with systemic disease such as Cushing's syndrome (Lewis et al, 1953)…”

“…This difierence in behaviour between similar organisms has led dermatologists in the past to search for predisposing factors and there are now a number of reports of chronic T.rubrum infections in association with systemic disease such as Cushing's syndrome (Lewis et al, 1953)…”

Immunology of Surface Fungi Dermatophytes

“…Underlying disease such as Cushing's syndrome, or adrenal hypercorticism (Canizares et al, 1959;Nelson and McNiece, 1959;Pillsbury and Jacobson, 1955), malignant lymphoma (Levene, 1973;Lewis et al, 1953), rheumatoid arthritis (Blank and Smith, 1960), or diabetes (Mandel, 1960), as well as treatment with immunosuppressive agents (Canizares et al, 1959;Lavalle, 1975;Burgoon et al, 1974;Marks and Dawber, 1972;Goss et al, 1963), has been associated with widespread intractable infections. Graham (1972) suggested that T. rubrum should also be considered as an opportunistic organism which takes advantage of a wide spectrum of systemic illnesses, in some instances masking the underlying disease that has altered the host-parasite relationship.…”