Generalized urticaria after ingestion of Raphanus sativus

Damiani, Elisabetta; Aloia, Anna Maria; Priore, M. G.; Nardulli, Stefania; Ferrannini, A.

doi:10.1016/j.anai.2010.10.018

Cited by 5 publications

(6 citation statements)

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“…This is the first case of hand urticaria, lip angioedema, and oropharyngeal pruritus to raw JR through IgEmediated immediate allergic reaction. Since 1974, 6 cases involving radish allergy have been reported in medical literature, besides the current case (Table 1) [2][3][4][5][6][7]. All the cases were of women with a median age of 46 (16-66) years.…”

Section: Discussionmentioning

confidence: 94%

“…Radish (Raphanus sativus L.), belonging to the mustard family (Cruciferae or Brassicaceae), is a common edible vegetable; the taproot of white radish is widely consumed in East Asia, both fresh and dried. Although mustard allergy is a well-known food hypersensitivity in children [1], only few reports on IgE-mediated hypersensitivity reactions caused by radish are reported [2][3][4][5][6]. To our knowledge, this is the first reported case of hand urticaria, lip angioedema, and oropharyngeal pruritus caused by raw Japanese radishes.…”

Section: Introductionmentioning

confidence: 83%

“…A Japanese article showed a case of allergic contact stomatitis caused for about 3 h after eating grated Japanese radish [7]. Five cases demonstrated positive SPT to the extract of raw radish, suggesting that the allergic reactions to radish may be due to IgE-mediated mechanisms [3][4][5][6]. However, the radish-specific antigen causing the allergy is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…All the cases were of women with a median age of 46 (16–66) years. In 4 cases including the current case, dermatologic manifestations, oral allergy, and anaphylaxis were caused by radish ( Raphanus sativus L.) while cooking and following a meal [ 2 , 5 , 6 ]. Two cases experienced urticaria and anaphylaxis after ingestion of food supplements containing black radish ( Raphanus sativus L. var niger ) [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the radish-specific antigen causing the allergy is unknown. Immunoblotting analysis in a previous case report demonstrated IgE reactivity in the patient’s serum corresponding to a 65-kDa protein in radish [ 5 ]. In the current case, immunoblotting analysis of denatured raw-grated radish revealed IgE reactivity corresponding to a 65-kDa protein in radish, in both patient and control sera; moreover, inhibition immunoblots revealed IgE reactivity in the patient sera to an 18-kDa protein in radish, but not to the 65-kDa protein.…”

Section: Discussionmentioning

confidence: 99%

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A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction

Abe

Ito

Harada

et al. 2021

Allergy Asthma Clin Immunol

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Background Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish. Case presentation A 48-year-old woman developed urticarial lesions on her hands after grating Japanese radish and also developed lip edema and oral itching when she ate a salad composed of raw Japanese radishes. Skin prick testing was positive to extract of grated Japanese radish. Moreover, immunoblotting analysis showed IgE reactivity in the patient’s serum to a single band at the 18 kDa in grated Japanese radish, suggesting that the heat-labile 18 kDa protein of raw Japanese radish may be a radish-specific antigen. Conclusions To the best of our knowledge, this is the first case report of a patient with hand urticaria, lip angioedema, and oropharyngeal pruritus to raw Japanese radish through IgE-mediated immediate allergic reaction.

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