A defense platform is usually based on two methods to make underwater acoustic warfare strategy decisions. One is through Monte-Carlo method online simulation, which is slow. The other is by typical empirical (database) and typical back-propagation (BP) neural network algorithms based on genetic algorithm (GA) optimization, which is less accurate and less robust. Therefore, this paper proposes a method to build an optimal underwater acoustic warfare feedback system using a three-layer GA-BP neural network and dropout processing of the neural network to prevent overfitting, so that the three-layer GA-BP neural network has adequate memory capability while still having suitable generalization capability. This method improves the accuracy and stability of the defense platform in making underwater acoustic warfare strategy decisions, thus increasing the survival probability of the defense platform in the face of incoming torpedoes. This paper uses the optimal underwater acoustic warfare strategies corresponding to incoming torpedoes with different postures as the sample set. Additionally, it uses a three-layer GA-BP neural network with an overfitting treatment for training. The prediction results have less error than the typical single-layer GA-BP neural network, and the survival probability of the defense platform improves by 6.15%. This defense platform underwater acoustic warfare strategy prediction method addresses the impact on the survival probability of the defense platform due to the decision speed and accuracy.