2020
DOI: 10.1128/iai.00879-19
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Generation and Evaluation of a Glaesserella (Haemophilus) parasuis Capsular Mutant

Abstract: Glaesserella (Haemophilus) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer’s disease, which causes significant morbidity and mortality in pigs worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, which has shown a correlation with isolate pathogenicity. To investigate the role the capsule plays in G. parasuis virulence and host interaction, a capsule mutant of the serovar 5 strain HS069 was generated (HS069Δcap… Show more

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Cited by 12 publications
(5 citation statements)
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“…Previous studies have shown that the deletion of CPS synthesis gene can promote the formation of biofilms (Petruzzi et al, 2017;Eberle et al, 2020). The deletion of wza gene of V. vulnificus CPS transfer protein caused that the CPS in bacterial capsule cannot be secreted to extracellular surface, and the formation of biofilms was significantly increased.…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…Previous studies have shown that the deletion of CPS synthesis gene can promote the formation of biofilms (Petruzzi et al, 2017;Eberle et al, 2020). The deletion of wza gene of V. vulnificus CPS transfer protein caused that the CPS in bacterial capsule cannot be secreted to extracellular surface, and the formation of biofilms was significantly increased.…”
Section: Discussionmentioning
confidence: 98%
“…Many studies have shown that the larval settlement and metamorphosis of various marine invertebrates are influenced by the chemical cue on marine biofilms (Dworjanyn and Pirozzi, 2008;Tamburri et al, 2008;Webster et al, 2011;Whalan and Webster, 2014). CPS, as a bacterial polysaccharide, has been demonstrated to affect the formation of bacterial biofilms (Petruzzi et al, 2017;Eberle et al, whether CPS synthesis gene regulates biofilm formation of marine bacterial biofilm and larval settlement and metamorphosis is still undefined. Here, a capC deletion strain of P. marina was created, and it was found that the DcapC strain with lower CPS production and lower exopolysaccharide on DcapC biofilms significantly prevented mussel settlement and metamorphosis.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have demonstrated that CPS and LOS are important virulence factors and confer serum resistance in G. parasuis [5,12,13,37]. However, the correlation between these polysaccharides and carbon source metabolism still awaits experimental investigation.…”
Section: Discussionmentioning
confidence: 99%
“…Piglets in the HPS4-YC-infected group were challenged intranasally (1 mL) and intraperitoneally (2 mL) with HPS4-YC (4.0 × 10 9 CFU/mL) on the same day. The infection methods and doses were determined from previously published references[ 17 , 21 ]. Blood samples were taken at 3, 5 and 7 days post-inoculation (dpi) with HPS4-YC for serum isolation.…”
Section: Methodsmentioning
confidence: 99%