Generation, Control, and Processing of Cellular Calcium Signals

Carafoli, Ernesto; Santella, Luigia; Branca, Donata; Brini, Marisa

doi:10.1080/20014091074183

Cited by 485 publications

(327 citation statements)

References 944 publications

(728 reference statements)

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“…It has yet to be determined if this represents the function of different androgen-binding proteins with a distinct cell type-dependent distribution or if there is one membrane androgen-binding protein that conveys its signal in a manner subject to other cell type-specific differences. Regardless, by altering [Ca 2+ ] i in unique ways the androgen exposed cell can use the same signaling molecule to specifically regulate different cellular functions [50].…”

Section: Androgens Can Interact With Intracellular Calcium Regulatorymentioning

confidence: 99%

Non-genomic actions of androgens

Foradori

Weiser

Handa

2008

Frontiers in Neuroendocrinology

412

244

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Previous work in the endocrine and neuroendocrine fields has viewed androgen receptors (AR) as a transcription factor activated by testosterone or one of its many metabolites. The bound androgen receptor acts as transcription factor and binds to specific DNA response elements in target gene promoters, causing activation or repression of transcription and subsequently protein synthesis. Over the past two decades evidence has begun to accumulate to implicate androgens, dependent or independent of the AR, in rapid actions at the cellular and organism level. Androgen's rapid time course of action; effects in the absence or inhibition of the cellular machinery necessary for transcription/translation; and/or the effects of androgens not able to translocate to the nucleus suggest a method of androgen action not initially dependent on genomic mechcanisms (i.e. non-genomic in nature). In the present paper the non-genomic effects of androgens are reviewed, along with a discussion of the possible role non-genomic androgen actions have on animal physiology and behavior.

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Section: Androgens Can Interact With Intracellular Calcium Regulatorymentioning

confidence: 99%

Non-genomic actions of androgens

Foradori

Weiser

Handa

2008

Frontiers in Neuroendocrinology

412

244

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“…For example, the Na + / Ca 2+ exchanger has a low affinity, but high capacity, resulting in the transport of up to 5000 ions per second (Carafoli et al, 2001). Such a transporter is useful when Ca 2+ is present in high concentrations (e.g.…”

Section: Ca 2+ Transport In Foraminiferamentioning

confidence: 99%

“…Besides providing energy, mitochondria pump cytosolic Ca 2+ and Mg 2+ , and therefore modulate the cell's [Ca 2+ ] and [Mg 2+ ] (Carafoli et al, 2001). This may be particularly important during calcification when the concentration of these ions increases locally.…”

Section: Chamber Growthmentioning

confidence: 99%

Biomineralization in perforate foraminifera

Nooijer

Spero

Erez

et al. 2014

Earth-Science Reviews

210

190

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a b s t r a c t a r t i c l e i n f oIn this paper, we review the current understanding of biomineralization in perforate foraminifera. Ideas on the mechanisms responsible for the flux of Ca 2+ and inorganic carbon from seawater into the test were originally based on light and electron microscopic observations of calcifying foraminifera. From the 1980s onward, tracer experiments, fluorescent microscopy and high-resolution test geochemical analysis have added to existing calcification models. Despite recent insights, no general consensus on the physiological basis of foraminiferal biomineralization exists. Current models include seawater vacuolization, transmembrane ion transport, involvement of organic matrices and/or pH regulation, although the magnitude of these controls remain to be quantified. Disagreement between currently available models may be caused by the use of different foraminiferal species as subject for biomineralization experiments and/or lack of a more systematic approach to study (dis)similarities between taxa. In order to understand foraminiferal controls on element incorporation and isotope fractionation, and thereby improve the value of foraminifera as paleoceanographic proxies, it is necessary to identify key processes in foraminiferal biomineralization and formulate hypotheses regarding the involved physiological pathways to provide directions for future research.

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“…PMCAs extrude Ca 2+ ions from the cell and may thus contribute to the regulation of global, and sub-cellular, concentrations of intracellular free Ca 2+ ([Ca 2+ ] i ) (Karaki et al, 1997;Carafoli et al, 2001;Cartwright et al, 2011). However, it is now evident that PMCAs also have important roles as scaffold proteins whereby they may play a key role in signal transduction (Schuh et al, 2001;Williams et al, 2006;Cartwright et al, 2007;Strehler, 2015).…”

Section: Introductionmentioning

confidence: 99%

Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension

Little

Cartwright

Neyses

et al. 2016

Pharmacology & Therapeutics

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The incidence of hypertension, the major modifiable risk factor for cardiovascular disease, is increasing. Thus, there is a pressing need for the development of new and more effective strategies to prevent and treat hypertension. Development of these relies on a continued evolution of our understanding of the mechanisms which control blood pressure (BP). Resistance arteries are important in the regulation of total peripheral resistance and BP; changes in their structure and function are strongly associated with hypertension. Anti-hypertensives which both reduce BP and reverse changes in resistance arterial structure reduce cardiovascular risk more than therapies which reduce BP alone. Hence, identification of novel potential vascular targets which modify BP is important. Hypertension is a multifactorial disorder which may include a genetic component. Genome wide association studies have identified ATP2B1, encoding the calcium pump plasma membrane calcium ATPase 1 (PMCA1), as having a strong association with BP and hypertension. Knockdown or reduced PMCA1 expression in mice has confirmed a physiological role for PMCA1 in BP and resistance arterial regulation. Altered expression or inhibition of PMCA4 has also been shown to modulate these parameters. The mechanisms whereby PMCA1 and 4 can modulate vascular function remain to be fully elucidated but may involve regulation of intracellular calcium homeostasis and/or comprise a structural role. However, clear physiological links between PMCA and BP, coupled with experimental studies directly linking PMCA1 and 4 to changes in BP and arterial function, suggest that they may be important targets for the development of new pharmacological modulators of BP.

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Generation, Control, and Processing of Cellular Calcium Signals

Cited by 485 publications

References 944 publications

Non-genomic actions of androgens

Non-genomic actions of androgens

Biomineralization in perforate foraminifera

Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension

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