Generation of Reactive Oxygen Metabolites by the Varicose Vein Wall

Głowiński, Jerzy; Głowiński, S

doi:10.1053/ejvs.2002.1656

Cited by 35 publications

(45 citation statements)

References 29 publications

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“…In the present study on VV and not its sequelae, complications or adverse manifestations, there has been a rise of these markers in numerous cases of VV. 1 According to Condezo-Hoyos et al, who compared the levels of MDA in patients with CVI versus Normal Individuals, and found marked levels of MDA in patients with CVI.…”

Section: Discussionmentioning

confidence: 99%

“…1 Later, two studies were performed by research groups with preliminary aim of establishing the role of oxidative stress in VV. The first study was conducted by Condezo-Hoyos et al were blood samples were obtained from patients of CVI of CEAP C2 stage patients versus healthy controls revealing a significant increase in MDA in the CVI patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A comparative study on the lipid peroxidation and total antioxidant status in patients with and without varicose veins

Shetty¹,

Ballal²,

Kumari³

et al. 2016

Int J Res Med Sci

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comparative study on the lipid peroxidation and total antioxidant status in patients with and without varicose veins

Shetty¹,

Ballal²,

Kumari³

et al. 2016

Int J Res Med Sci

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“…Mitochondria are the main source of cell energy and are involved in the generation of reactive oxygen species in vascular SMC and other cell types [34]. The decrease in oxygen impairs energy production and generation of reactive oxygen metabolites by these organelles in varicose veins [35]. CVI is known to be associated with ischemic conditions [36].…”

Section: Discussionmentioning

confidence: 99%

Identification of Differentially Expressed Genes in Human Varicose Veins: Involvement of Matrix Gla Protein in Extracellular Matrix Remodeling

et al. 2007

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This study was designed to identify the global pattern of differentially expressed genes in human varicose veins. Using suppressive subtractive hybridization, we identified overexpression of genes known to be associated with extracellular matrix remodeling, including collagen III, tissue inhibitor of metalloproteinases I, dermatopontin, matrix Gla protein (MGP) and tenascin C. Real-time polymerase chain reaction analysis confirmed the differential expression of these genes. The overexpression of MGP transcript was associated with increased MGP level in varicose veins, in particular the undercarboxylated form of the protein. Smooth muscle cells from varicose veins showed increased proliferation rate and enhanced matrix mineralization. This observation correlated with the presence of ectopic mineralization areas in the varicose vein walls. The use of warfarin, to inhibit MGP activity, or siRNA targeting MGP transcript induced a reduction in the exacerbated proliferation of varicose vein smooth muscle cells. Our results suggest that high expression of MGP in varicose veins may contribute to venous wall remodeling by affecting proliferation and mineralization processes probably through impaired carboxylation of MGP. In addition, suppressive subtractive hybridization results also produce a profile of differentially expressed genes in varicose veins, in particular extracellular matrix components. Further study of these genes will provide insights into their specific roles in the etiology of venous disease.

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“…[2][3][4][5][6] Regardless of these factors, this is manifested by venous and valvular dilation. [2][3][4]7,8] Some epidemiological studies suggest that this may be the result of abnormalities in the enzymes involved in the functioning of homocysteine metabolism. [9] The recurrence of varicose veins gives rise to significant expenses and a burden on public health, hence, the need for further studies in this area.…”

Section: Introductionmentioning

confidence: 99%

Radiology and management of recurrent varicose veins: Risk factors analysis using artificial neural networks

Imene¹,

Seddik²,

Farid³

et al. 2018

JMRPS

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Background: From the epidemiological point of view, certain factors involved in the appearance of varicose veins are preponderant such as multiple pregnancies, age, and also certain races. Physiologically, venous valve dysfunction can also be a factor. Here, radiologists intervene to determine venous insufficiency. Doppler ultrasound (US) and tomography are often the most used in this detection. Certain other factors contribute to their recidivism. Aims: Some factors that occur in the recurrence of varicose veins are extrinsic such as age, sex, or genetic factor. On the other hand, certain factors are linked to an inadequate surgical procedure that can be partly explained by a poor radiological or methodological reading. The aim of this study is to prevent recurring complications that may occur the analysis of the factors of these is necessary. Materials and Methods: In our study, 62 patients were operated in our general surgery department during the period from January 2016 to September 2017. The pre-operative clinical examination included, among others, the radiological examination using a Doppler US. Patients who have had a recurrence are classified from the identification of the possible causes. Since the causes are complex and vary from one person to another, this makes them very difficult to analyze by conventional methods. We proposed an intelligent system based on artificial neural networks. Results: Once the system is established, this will identify the most important factor in the recurrence of varicose veins. By randomly changing the parameters at the input one by one and we record the effect that each produces on the recurrence rate at the output. Conclusion: The proposed system with its very strong inters connectivity, and the support of all possible combinations with the weight of each factor makes it possible to extract the predominant cause. With its learning from the real values recorded, and the optimal function created between the two input-output spaces, it becomes very easy to identify the main cause that leads to recidivism.

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Generation of Reactive Oxygen Metabolites by the Varicose Vein Wall

Abstract: varicose veins, especially those complicated with superficial thrombophlebitis revealed increased free radical generation. Its sources might be neutrophils, and in vv complicated with superficial thrombophlebitis-xanthine oxidase.

Cited by 35 publications

References 29 publications

A comparative study on the lipid peroxidation and total antioxidant status in patients with and without varicose veins

A comparative study on the lipid peroxidation and total antioxidant status in patients with and without varicose veins

Identification of Differentially Expressed Genes in Human Varicose Veins: Involvement of Matrix Gla Protein in Extracellular Matrix Remodeling

Radiology and management of recurrent varicose veins: Risk factors analysis using artificial neural networks

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