2024
DOI: 10.1002/biot.202400090
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Generation of stable suspension producer cell lines for serum‐free lentivirus production

Maximilian Klimpel,
Monica Terrao,
Melina Bräuer
et al.

Abstract: The production of lentiviral vectors (LVs) pseudotyped with the vesicular stomatitis virus envelope glycoprotein (VSV‐G) is limited by the associated cytotoxicity of the envelope and by the production methods used, such as transient transfection of adherent cell lines. In this study, we established stable suspension producer cell lines for scalable and serum‐free LV production derived from two stable, inducible packaging cell lines, named GPRG and GPRTG. The established polyclonal producer cell lines produce s… Show more

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