Generic Compound Isolation Using Solid-Phase Trapping as Part of the Chromatographic Purification Process. Part 1. Proof of Generic Trapping Concept

Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2006

“…Publications appeared in 2006 on new polymer supports, – solid-phase trapping for compound isolation, pyridyl tags as phase labels, NMR functional libraries, a molecular building kit for spirocycles, target-family privileged substructures, and in silico identification of biologically active heterocyclic scaffolds . Selected high throughput chemistry reviews published in 2006 include topics on fluorous chemistry, – multicomponent condensations, , enantioselective synthesis on the solid phase, automated synthesis of heterocycles on the solid phase, fragment-based lead discovery, DNA-encoded chemical libraries, , dynamic combinatorial chemistry, in situ click chemistry, approaches to preparing discovery libraries, defining the medicinal chemistry diversity space, chemical genomics, DOS, structure-based design and library synthesis, SPOT synthesis, resin-bound reagents and catalysts, and parallel medicinal chemistry …”

“…52 The remaining selections describe new biselectrophilic annulation reagents to prepare piperazines and diazacycles, 250 the simultaneous processing of two heterocycles, 196 novel variants on multicomponent condensation reactions, 109,159,398,350,363 DOS and natural product-based libraries 19,200,217,240,262 and libraries/new methodology generated using fluorous technology. 98,185,282,419,420 Publicationsappearedin2006onnewpolymersupports, [430][431][432] solid-phase trapping for compound isolation, 433 pyridyl tags as phase labels, 434 NMR functional libraries, 435 a molecular building kit for spirocycles, 436 target-family privileged substructures, 437 and in silico identification of biologically active heterocyclic scaffolds. 438 Selected high throughput chemistry reviews published in 2006 include topics on fluorous chemistry, [439][440][441][442][443][444][445] multicomponent condensations, 447,448 enantioselective synthesis on the solid phase, 449 automated synthesis of heterocycles on the solid phase, 450 fragmentbased lead discovery, 451 DNA-encoded chemical libraries, 452,…”