Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy

Fan, Wenpei; Lü, Nan; Shen, Zheyu; Tang, Wei; Shen, Bo; Cui, Zhaowen; Shan, Lingling; Yáng, Zhèn; Wang, Zhantong; Jacobson, Orit; Zhou, Zijian; Liu, Yijing; Hu, Ping; Yang, Weijing; Song, Jibin; Zhang, Yang; Zhang, Liwen; Khashab, Niveen M.; Aronova, Maria A.; Lu, Guangming; Chen, Xiaoyuan

doi:10.1038/s41467-019-09158-1

Cited by 130 publications

(80 citation statements)

References 57 publications

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“…The results demonstrate that BiOI QDs under X‐ray irradiation can effectively inhibit tumor cell proliferation. Considering that the enhanced radiotherapeutic efficacy may be attributed to the oxidative damage of ROS to DNA generated by BiOI QDs under X‐ray irradiation, the damage of the DNA double‐strand was evaluated via γ‐H 2 AX detection in 4T1 cells. Compared with the group treated with X‐ray alone, obvious γ‐H 2 AX foci density is observed in the 4T1 cells treated with BiOI QDs under X‐ray irradiation, exhibiting about 5.87‐fold enhancement (Figure d,e).…”

Section: Resultsmentioning

confidence: 99%

Ultrasmall BiOI Quantum Dots with Efficient Renal Clearance for Enhanced Radiotherapy of Cancer

et al. 2020

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Emerging strategies involving nanomaterials with high‐atomic‐number elements have been widely developed for radiotherapy in recent years. However, the concern regarding their potential toxicity caused by long‐term body retention still limits their further application. In this regard, rapidly clearable radiosensitizers are highly desired for practical cancer treatment. Thus, in this work, ultrasmall BiOI quantum dots (QDs) with efficient renal clearance characteristic and strong permeability inside solid tumor are designed to address this issue. Additionally, considering that injection methods have great influence on the biodistribution and radiotherapeutic efficacy of radiosensitizers, two common injection methods including intratumoral injection and intravenous injection are evaluated. The results exhibit that intratumoral injection can maximize the accumulation of radiosensitizers within a tumor compared to intravenous injection and further enhance radiotherapeutic efficacy. Furthermore, the radiosensitizing effect of BiOI QDs is revealed, which is not only attributed to the radiation enhancement of high‐Z elements but also is owed to the •OH production via catalyzing overexpressed H2O2 within a tumor by BiOI QDs under X‐ray irradiation. As a result, this work proposes a treatment paradigm to employ ultrasmall radiosensitizers integrated with local intratumoral injection to realize rapid clearance and high‐efficiency radiosensitization for cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Ultrasmall BiOI Quantum Dots with Efficient Renal Clearance for Enhanced Radiotherapy of Cancer

et al. 2020

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“…The final H–SiO 2 was attained after washing with distilled water several times and drying in a vacuum overnight at 60 °C. 20 , 21 …”

Section: Experimental Methodsmentioning

confidence: 99%

Long-Term Stable Hollowed Silicon for Li-Ion Batteries Based on an Improved Low-Temperature Molten Salt Strategy

Zheng

Liu

et al. 2020

ACS Omega

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Nanostructured hollow silicon has attracted tremendous attention as high-performance anode materials in Li-ion battery applications. However, the large-scale production of pure hollowed silicon with long cycling stability is still a great challenge. Here, we report an improved low-temperature molten salt strategy to synthesize nanosized hollowed silicon with a stable structure on a large scale. As an anode material for rechargeable lithium-ion batteries, it exhibits a high capacity, excellent long cycling, and steady rate performance at different current densities. Especially, a high reversible capacity of 2028.6 mA h g –1 at 0.5 A g –1 after 150 cycles, 994.3 mA h g –1 at 3 A g –1 after 500 cycles, and 538.8 mAh g –1 at 5 A g –1 after 1200 cycles could be obtained. This kind of nanosized hollowed silicon can be applied as a basic anode material in silicon-based composites for long-term stable Li-ion battery applications.

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“…4(b)), where the metal showed high X-ray absorption attenuation as well as increased tumor oxygenation by transforming intracellular H2O2 to O2 [60]. Alternatively, nanoparticles that release cytotoxic carbon monoxide or nitric oxide upon irradiation also showed on-demand therapeutic effect without reliance on oxygen [61,62]. All these nanoparticlebased strategies against hypoxia-associated radioresistance promoted tumor remission in vivo in mice.…”

Section: X-ray As Ionizing Radiationmentioning

confidence: 99%

Nanoparticles for targeted cancer radiotherapy

Pallares

Abergel

2020

Nano Res.

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Radiotherapy, where ionizing radiation is locally delivered either through an external beam or by surgically implanting radionuclidebased seeds in the tumor, is one of the gold standard treatments for cancer. Due to the non-selective nature of radiation, healthy tissue surrounding the cancerous region is usually affected by the treatment. Hence, new strategies, including targeted alpha therapy, are being studied to improve the selectivity of the treatment and minimize side effects. Several challenges, however, limit the current development of targeted radiotherapy, such as the functionalization of the therapeutic agent with targeting vectors and controlling the release of recoiling daughters. Nanoparticles offer unique opportunities as drug delivery vehicles, since they are biocompatible, enhance the cellular uptake of drugs, and are easily functionalized with targeting molecules. In this review, we examine how nanoparticles can be used for targeted radiotherapy, either as sensitizers of external beams or as delivery vehicles for therapeutic radionuclides. We describe the clinical relevance of different types of nanoparticles, followed by an analysis of how these nanoconstructs can solve some of the main limitations of conventional radiotherapy. Finally, we critically discuss the current situation of nanoparticle-based radiotherapy in clinical settings and challenges that need to be overcome in the future for further development of the field.

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Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy

Cited by 130 publications

References 57 publications

Ultrasmall BiOI Quantum Dots with Efficient Renal Clearance for Enhanced Radiotherapy of Cancer

Ultrasmall BiOI Quantum Dots with Efficient Renal Clearance for Enhanced Radiotherapy of Cancer

Long-Term Stable Hollowed Silicon for Li-Ion Batteries Based on an Improved Low-Temperature Molten Salt Strategy

Nanoparticles for targeted cancer radiotherapy

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