Genes and SNPs Associated with Non-hereditary and Hereditary Colorectal Cancer

Nassiri, Mohammadreza; Kooshyar, Mohammad Mahdi; Roudbar, Zahra; Mahdavi, Manijeh; Doosti, Mohammad

doi:10.7314/apjcp.2013.14.10.5609

Cited by 27 publications

(17 citation statements)

References 40 publications

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“…Although it has been shown that SMAD7 has a compounding role as an intracellular mediator of TGF-b typeI receptor in cancer development, the relevance of several genetic variants within SMAD7 with CRC has been proved by several studies (Thompson et al, 2009;Slattery et al, 2010;Li et al, 2011;Nassiri et al, 2013). Singlenucleotide polymorphisms (SNPs) were determined as the most frequent and subtle genetic variation in the human genome and has great potential for application to association studies of multifactorial disorder (Kirk et al, 2002).…”

mentioning

confidence: 99%

Lack of Influence of the SMAD7 Gene rs2337107 Polymorphism on Risk of Colorectal Cancer in an Iranian Population

Akbari

Safari-Alighiarloo²,

Haghighi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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SMAD7 has been identified as a functional candidate gene for colorectal cancer (CRC). SMAD7 protein is a known antagonist of the transforming growth factor beta (TGF-b) signaling pathway which is involved in tumorigenesis. Polymorphisms in SMAD7 may thus alter cancer risk. The aim of this study was to investigate the influence of a SMAD7 gene polymorphism (rs2337107) on risk of CRC and clinicopathological features in an Iranian population. In total, 210 subjects including 105 patients with colorectal cancer and 105 healthy controls were recruited in our study. All samples were genotyped by TaqMan assay via an ABI 7500 Real Time PCR System (Applied Biosystems) with DNA from peripheral blood. The polymorphism was statistically analyzed to investigate the relationship with the risk of colorectal cancer and clinicopathological properties. Logistic regression analysis revealed that there was no significant association between rs2337107and the risk of colorectal cancer. In addition, no significant association between genotypes and clinicopathological features was observed (p value>0.05). Although there was not any association between genotypes and disorder, CT was the most common genotype in this population. This genotype prevalence was also higher in the patients with well grade (54.9%) and colon (72.0%) tumors. Our results provide the first evidence that this polymorphism is not a potential contributor to the risk of colorectal cancer and clinicopathological features in an Iranian population, and suggests the need of a large-scale case-control study to validate our results.

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mentioning

confidence: 99%

Lack of Influence of the SMAD7 Gene rs2337107 Polymorphism on Risk of Colorectal Cancer in an Iranian Population

Akbari

Safari-Alighiarloo²,

Haghighi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Although this meta-analysis did not show the significant association between XRCC3 rs861539 polymorphism and oral cancer risks, the present results also provided new evidence for the susceptibility and etiology of oral cancer. In recent years, there are some meta-analyses about XRCC3 polymorphisms and cancer risks, which comprised breast cancer, cervical cancer, colorectal cancer, gliomas and head and neck caner published in the journal Asian Pac J Cancer Prev and the results are not concordant, suggesting this polymorphism plays different role in diverse types of cancer (Yin et al, 2012;Jiang et al, 2013;Nassiri et al, 2013;Qin et al, 2013;Mao et al, 2014). It is well known that systematic review and meta-analyses are considered the highest level of evidence in Evidencebased Medicine.…”

Section: Discussionmentioning

confidence: 99%

Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

Zhang

Cui²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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-1.11). In the stratified analysis by ethnicity, no significant associations were found among Asians and Caucasians. On stratification by tumor type, no significant associations were found for cancer and oral premalignant lesions. Conclusions: The XRCC3 gene polymorphism was not found to be associated with the risk of oral cancer. Considering the limited quality of the included case-control studies, more high quality studies with large sample size are needed to verify the above conclusion.

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“…Frequent genetic variations -single nucleotide polymorphisms (SNPs) -may play an important role in colorectal carcinogenesis. Detecting single nucleotide variations in genes associated with CRC and using them as disease markers may improve cancer diagnosis and treatment planning in the near future (Nassiri et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Common Genetic Variants of PSCA, MUC1 and PLCE1 Genes are not Associated with Colorectal Cancer

Kupčinskas

Gyvyte²,

Bruzaite³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Genes and SNPs Associated with Non-hereditary and Hereditary Colorectal Cancer

Cited by 27 publications

References 40 publications

Lack of Influence of the SMAD7 Gene rs2337107 Polymorphism on Risk of Colorectal Cancer in an Iranian Population

Lack of Influence of the SMAD7 Gene rs2337107 Polymorphism on Risk of Colorectal Cancer in an Iranian Population

Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

Common Genetic Variants of PSCA, MUC1 and PLCE1 Genes are not Associated with Colorectal Cancer

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