Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

Zhang, Enjiao; Cui, Zhigang; Xu, Zhongfei; Duan, Weiyi; Huang, Shao Mei; Tan, Xiaoheng; Yin, Zhihua; Sun, C. P.; Lu, Li

doi:10.7314/apjcp.2014.15.23.10329

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…So far, there is only one meta-analysis report regarding the association of XRCC3 Thr241Met polymorphism to oral cancer risk reporting that XRCC3 Thr241Met polymorphism is irrelevant to the risk of oral cancer (26). However, the authors included upper aero-digestive cancer and leukoplakia, a common precancer lesion, in their association analysis.…”

Section: Discussionmentioning

confidence: 99%

A literature review and systematic meta-analysis on XRCC3 Thr241Met polymorphism associating with susceptibility of oral cancer

et al. 2019

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Oral cancer is very common, occurring on head as well as neck region with poor prognosis. The X-ray repair cross-complementing group 3 (XRCC3) gene contained in DNA repairing pathway has been investigated for its functional role in oral cancer. Nevertheless, the corresponding results are inconclusive. This study investigated the association of XRCC3 Thr241Met polymorphism regarding oral cancer risk. Article and literature searches were performed using Embase, Medline, PubMed, Wanfang and China National Knowledge Infrastructure (CNKI) databases with a manual search. The keywords of ‘ XRCC3 or X-ray repair cross complementing protein 3’, ‘polymorphism or SNP’, ‘oral cancer or oral squamous cell carcinoma’ and their combinations were used to search literature. In accordance with the criteria of inclusion, we focused on only case-and-control studies with the distribution of genotypes and alleles being available to be extracted. Systematic meta-analysis was conducted via the STATA software (version 11.0). After a comprehensive literature collection and review, 1,615 oral cancer cases and 1,897 matched controls extracted from 7 articles were included for this meta-analysis. Our results show that only Met/Met (TT) genotype with the recessive model was associated with high risk of oral cancer (CC + CT vs. TT, OR=1.81, P=0.001, 95% CI=1.28–2.567). A significant relationship was identified under both homozygous and recessive model in Asians (CC vs. TT: OR=2.15, 95% CI=1.107–4.170, P=0.024; CT + CC vs. TT: OR=2.140, 95% CI=1.105–4.144, P=0.024), but not among Caucasians (P>0.05). The results indicate that XRCC3 241Met allele might be a potential factor for oral cancer risk, particularly among Asian population. A further study using a larger population and more ethnicities should be performed to confirm the findings.

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Section: Discussionmentioning

confidence: 99%

A literature review and systematic meta-analysis on XRCC3 Thr241Met polymorphism associating with susceptibility of oral cancer

et al. 2019

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“…The genes associated with the homologous repair system, RAD51 and XRCC3 , play a key role in maintaining genomic stability by means of facilitating a homology search and catalyzing the invasion of single‐stranded tails into the DNA double helix of a homologous chromatid (Li et al, ). These genes have been shown to play a critical role in maintaining chromosomal integrity and protecting against carcinogenic factors in many types of cancer, but the exact function of RAD51 and XRCC3 in the progression of oral and oropharyngeal SCC is not yet fully understood (Gresner et al, ; Khlifi et al, ; Zhang, Cui, et al, ). Studies on allelic variants of these genes are of great importance, as they are responsible for correcting damaged nucleotides generated by exposure to carcinogens, which is necessary to maintain correct cellular functions and homeostasis (Dos Reis et al, ; Kumar et al, ; Nowacka‐Zawisza et al, ).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas

Santos

Matos

et al. 2018

Oral Diseases

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Association between XRCC3 Thr241Met polymorphism and nasopharyngeal carcinoma risk: evidence from a large-scale case-control study and a meta-analysis

Cui

Zuo²,

Lian³

et al. 2016

Tumor Biol.

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The X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism (rs861539, C > T) has drawn wide attentions as its association with cancer risk and its involvement in DNA repair. Several studies have attempted to link rs861539 to nasopharyngeal cancer (NPC) risk; however, the sample sizes of these studies are small and the results are controversial. To investigate the relationship of rs861539 and NPC susceptibility, we conducted a large-scale case-control study involving 4001 NPC cases and 2967 controls of southern Chinese. Logistic regression analysis revealed significant association for rs861539 and NPC risk under the recessive model (TT vs. CT + CC) with adjustment of age and gender (odds ratio, OR = 2.72; 95 % CI 1.10-6.72; P = 0.03). Further, meta-analysis involving 4457 NPC cases and 4132 controls from four studies showed consistent association of TT carriers and NPC risk (OR = 3.12; 95 % CI 1.58-6.13; P = 0.001). Taken together, our findings based on large-scale sample size suggested rs861539 at XRCC3 to be associated with NPC risk through recessive model.

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Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

Cited by 5 publications

References 26 publications

A literature review and systematic meta-analysis on XRCC3 Thr241Met polymorphism associating with susceptibility of oral cancer

A literature review and systematic meta-analysis on XRCC3 Thr241Met polymorphism associating with susceptibility of oral cancer

Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas

Association between XRCC3 Thr241Met polymorphism and nasopharyngeal carcinoma risk: evidence from a large-scale case-control study and a meta-analysis

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