Genes for fibrogenesis in the determination of susceptibility to myocardial infarction

Goncharova, I. A.; Makeeva, O. A.; Golubenko, M. V.; Марков, А. В.; Tarasenko, N. V.; Слепцов, А. А.; Puzyrev, V. P.

doi:10.1134/s0026893315060096

Cited by 9 publications

(8 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study confirmed the association of rs1333049 with myocardial infarction in the general population; this finding is consistent with the results of studies on some groups of patients in Russia [11,12,35] and abroad [35,36,37,38].…”

Section: Discussionsupporting

confidence: 92%

“…Nonetheless, they uncovered an association with subsequent revascularization, which may support the postulated mechanism of promotion of atheroma development by chromosomal region 9p21 [10]. Data from Russian patients have confirmed the correlation of rs1333049 with myocardial infarction but not with type 2 diabetes; these studies had some limitations because they involved only small groups [11,12]. The specificity of rs1333049 as a risk factor of CVDs in various populations and ethnic groups makes this topic relevant for the populations living under various geographic/climatic conditions, including the residents of Western Siberia (Russia).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of Polymorphism rs1333049 (Located at 9P21.3) in the White Population of Western Siberia and Associations with Clinical and Biochemical Markers

et al. 2019

View full text Add to dashboard Cite

The 9p21.3 chromosomal region is a marker of the risk of cardiovascular diseases. The aim of this study was to analyze single-nucleotide polymorphism rs1333049 (chr9:22125504) in the population of Western Siberia (Russia) and possible associations with clinical and biochemical parameters. The population included in the analyses was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 participants, >90% white, aged 45–69, males: 50%). In total, 2729 randomly selected patients were included. Plasma lipid levels were determined by standard enzymatic assays. Rs1333049 was analyzed by RT-PCR (BioLabMix, Russia). Frequencies of rs1333049 genotypes C/C (homozygote), C/G (heterozygote), and G/G were 0.22, 0.51, and 0.27 in this population. The Allele G frequency was 0.53. We found an association of allele G with total cholesterol and low-density lipoprotein cholesterol levels among male participants (p = 0.004 and p = 0.002, respectively). Allele C was significantly associated with the risk of myocardial infarction among the male participants (odds ratio 1.96, 95% confidence interval 1.14–3.38, p = 0.017) and the study population (odds ratio 1.83, 95% confidence interval 1.23–2.72, p = 0.004). Thus, rs1333049 is associated with myocardial infarction in the white population of Western Siberia (Russia).

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Analysis of Polymorphism rs1333049 (Located at 9P21.3) in the White Population of Western Siberia and Associations with Clinical and Biochemical Markers

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Генетический профиль различных сочетанных заболеваний может существенно как различаться между собой, так и отличаться от отдельных несочетанных форм патологий. Так, показано, что ИМ, не сопровождающийся традиционными факторами риска, и синтропия сердечно-сосудистого континуума -генетически обособленные формы ССЗ с уникальной структурой генетической подверженности [7,15,16].…”

Section: Discussionunclassified

“…К настоящему времени получены доказательства того, что сердечно-сосудистые заболевания (ССЗ) обладают высоким коэффициентом наследуемости. Полно геномные ассоциативные (GWAS), перекрестные случай-контроль и проспективные исследования выявили широкий спектр генетических вариантов, в том числе генов, регулирующих формирование фиброзной ткани, ассоциированных с ИБС, атеросклерозом и ИМ [3][4][5][6][7][8][9]. Экспрессионные исследования также показали, что гены, регулирующие метаболизм внеклеточного матрикса, влияют на развитие атеросклероза артерий различных сосудистых бассейнов [10].…”

unclassified

Fibrogenesis Genes and Susceptibility to Coronary Atherosclerosis

Goncharova¹,

Печерина

Марков³

et al. 2018

CARDIO

Self Cite

View full text Add to dashboard Cite

show abstract

“…KIAA1462 is newly identified locus, which is associated with coronary artery disease, the KIAA1462 protein participates in the regulation of adherens junctions and cytoskeleton formation in endothelial cells [16]. Thus, it is involved in the support of integrity and permeability of the endothelium, which is always exposed to the mechanical action of blood flow.…”

Section: Introductionmentioning

confidence: 99%

The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction

Wang

Zhang

et al. 2019

Hum Genomics

View full text Add to dashboard Cite

BackgroundThe association of platelet endothelial cell adhesion molecule 1 (PECAM1), hypoxia-inducible factor 1 subunit alpha (HIF1A), and KIAA1462 in myocardial infarction (MI) was investigated. The study included 401 Han Chinese MI patients and 409 controls. Three tag single-nucleotide polymorphisms (SNPs)—PECAM1 rs1867624, HIF1A rs2057482, and KIAA1462 rs3739998—were selected. SNP genotyping was performed by an improved multiplex ligation detection reaction assay. A systematic review and meta-analysis of studies including 3314 cases and 2687 controls on the association of 5 HIF1A SNPs and the overall risk of MI or coronary artery disease (CAD) was performed.ResultsThe rs1867624 variants were associated with high TG concentrations (p = 0.040) and the rs2057482 variants were associated with decreased HDL-C in MI patients compared with the control group (p = 0.003). Rs2057482 SNP interacted with age to influence TC levels. The SNP of rs3739998 interacted with sex and hypertension to modulate CRE and TG levels, respectively (p < 3.04E-5-0.002). No association between the three SNPs and susceptibility to MI was found (p > 0.05 for all). In the meta-analysis of HIF1A, the rs11549465 C > T and rs10873142 T > C polymorphisms, but not rs2057482, rs11549467, and rs41508050, were correlated with overall MI or CAD risk.ConclusionsTaken together, this study provides additional evidence that genetic variation of the PECAM1 rs1867624 and HIF1A rs2057482 can mediate lipid levels in MI patients.Electronic supplementary materialThe online version of this article (10.1186/s40246-018-0189-8) contains supplementary material, which is available to authorized users.

show abstract

Genes for fibrogenesis in the determination of susceptibility to myocardial infarction

Cited by 9 publications

References 51 publications

Analysis of Polymorphism rs1333049 (Located at 9P21.3) in the White Population of Western Siberia and Associations with Clinical and Biochemical Markers

Analysis of Polymorphism rs1333049 (Located at 9P21.3) in the White Population of Western Siberia and Associations with Clinical and Biochemical Markers

Fibrogenesis Genes and Susceptibility to Coronary Atherosclerosis

The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction

Contact Info

Product

Resources

About