The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction

Li, Yilan; Wang, Shipeng; Zhang, Dandan; Xu, Xueming; Yu, Bo; Zhang, Yao

doi:10.1186/s40246-018-0189-8

Cited by 5 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent advances in this area have also highlighted a shared mechanistic pathway involving inflammation and endothelium oxidation in endothelial dysfunction (212,213) . For instance, SNPs involved in processes related to endothelial and vascular health such as vascular endothelial growth factor receptor, platelet/endothelial cell adhesion molecule-, endothelial nitric oxide synthase and endothelin-1 contribute to local and systemic vascular disorders (214)(215)(216)(217)(218) , yet studies had small sample sizes, were limited in number or did not account for gene-environment interaction.…”

Section: The Link Between Risk Factors and Endothelial Dysfunction An Intermediary Marker Of Cvdmentioning

confidence: 99%

A synthesis of pathways linking diet, metabolic risk and cardiovascular disease: a framework to guide further research and approaches to evidence-based practice

Vale¹,

Buckner²,

Mitrofan³

et al. 2021

Nutr. Res. Rev.

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is the most common non-communicable disease occurring globally. Although previous literature have provided useful insights on the important role that diet play in CVD prevention and treatment, understanding the causal role of diets is a difficult task considering inherent and introduced weaknesses of observational (e.g., not properly addressing confounders and mediators) and experimental research designs (e.g., not appropriate or well-designed). In this narrative review, we organised current evidence linking diet, as well as conventional and emerging physiological risk factors with CVD risk, incidence and mortality in a series of diagrams. The diagrams presented can aid causal inference studies as they provide a visual representation of the types of studies underlying the associations between potential risk markers/factors for CVD. This may facilitate the selection of variables to be considered and the creation of analytical models. Evidence depicted in the diagrams was systematically collected from studies included in the British Nutrition Task Force report on Diet and CVD and database searches, including Medline and Embase. Although several markers and disorders linked to conventional and emerging risk factors for CVD were identified, the causal link between many remains unknown. There is a need to address the multifactorial nature of CVD and the complex interplay between conventional and emerging risk factors with natural and built environments, while bringing the life course and the role of additional environmental factors into the spotlight.

show abstract

Section: The Link Between Risk Factors and Endothelial Dysfunction An Intermediary Marker Of Cvdmentioning

confidence: 99%

A synthesis of pathways linking diet, metabolic risk and cardiovascular disease: a framework to guide further research and approaches to evidence-based practice

Vale¹,

Buckner²,

Mitrofan³

et al. 2021

Nutr. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…Liu et al identified five genes (encoding signal-induced proliferation-associated 1, transcription factor 21, SMAD family member 3, FES proto-oncogene, and platelet-derived growth factor receptor alpha) that might modulate CAD risk through human coronary artery smooth muscle cells, with all genes having relevant functional roles in vascular remodeling [5]. Furthermore, Li et al provided additional evidence that a genetic variation in the platelet endothelial cell adhesion molecule 1-encoding gene, namely rs1867624, and hypoxia-inducible factor 1 subunit alpha gene, namely rs2057482, can modulate lipid levels in myocardial infarction patients [6].…”

Section: Introductionmentioning

confidence: 99%

The rs1892818 polymorphism of ADRB3 is associated with coronary artery disease in a Han population

Zhang

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Coronary artery disease (CAD) is the most common type of heart disease and causes high morbidity worldwide. The β3-adrenergic receptor gene (ADRB3) is potentially linked to obesity, insulin resistance, diabetes, and hypertension based on its role in energy homeostasis and lipolysis in human adipose tissue. However, the relationship between ADRB3 gene polymorphisms and CAD remains unclear. we sought to assess this association in the Han and Uygur populations of China. Methods: We used the following two case-control studies: a Han population (308 CAD patients and 294 control subjects) and an Uygur population (259 CAD patients and 161 control subjects). All 1022 participants were genotyped for the two single nucleotide polymorphisms (SNPs) (rs1892818, rs9693898) of ADRB3 using real-time polymerase chain reaction (TaqMan). Results: We found that the rs1892818 CT genotype (8.5% compared with 3.9%, P = 0.019) and T allele (4.3% compared with 1.9%, P = 0.021) were more frequent in control subjects than in CAD patients of the Han, but not Uygur population. No significant differences in rs9693898 of ADRB3 were found between CAD patients and control subjects for both populations. After adjusting for other confounders, logistic regression analysis suggested that the difference remained significant between the two groups in the Han population (CT compared with CC, P = 0.036, OR = 0.410, 95% CI: 0.178–0.944). Conclusion: Our results suggest that ADRB3 rs1892818 is associated with CAD in a Han population and that the CT genotype of ADRB3 rs1892818 might be a protective factor for CAD in Han individuals.

show abstract

Novel Biomarkers of Cardiovascular Disease

Jensen¹,

Palaskas²,

Luo³

et al. 2024

Comprehensive Precision Medicine

View full text Add to dashboard Cite

The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction

Cited by 5 publications

References 32 publications

A synthesis of pathways linking diet, metabolic risk and cardiovascular disease: a framework to guide further research and approaches to evidence-based practice

A synthesis of pathways linking diet, metabolic risk and cardiovascular disease: a framework to guide further research and approaches to evidence-based practice

The rs1892818 polymorphism of ADRB3 is associated with coronary artery disease in a Han population

Novel Biomarkers of Cardiovascular Disease

Contact Info

Product

Resources

About