Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis

Chisini, Luiz Alexandre; Cademartori, Mariana Gonzalez; Conde, Marcus Cristian Muniz; Tovo‐Rodrigues, Luciana; Corrêa, Marcos Britto

doi:10.1007/s00784-019-03146-x

Cited by 15 publications

(6 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We are aware that our study may have some limitations. Although we found an association between SNP and caries, most studies conclude that genetics is a small component of the susceptibility to dental caries (Chisini, Cademartori, Conde, Costa, et al 2020; Chisini, Cademartori, Conde, Tovo-Rodrigues et al 2020). Biological (biofilm, microflora), socioeconomic, and behavioral factors are known to be the main reasons for caries occurrence (Nascimento et al 2020).…”

Section: Discussioncontrasting

confidence: 84%

Sweet Taste Receptor Gene and Caries Trajectory in the Life Course

et al. 2023

Self Cite

View full text Add to dashboard Cite

This study aims to investigate whether the trajectory of dental caries in the life course is associated with rs307355 ( TAS1R3) and rs35874116 ( TAS1R2) and if there is an epistatic association between rs307355 ( TAS1R3) and rs35874116 ( TAS1R2). A representative sample of all 5,914 births from the 1982 Pelotas birth cohort was prospectively investigated, and the decayed, missing, and filled teeth (DMF-T) components were assessed at ages 15 ( n = 888), 24 ( n = 720), and 31 ( n = 539) y. Group-based trajectory modeling was used to identify groups with similar trajectories of DMF-T components in the life course. Genetic material was collected, and rs307355 ( TAS1R3) and rs35874116 ( TAS1R2) were genotyped. Ethnicity was evaluated using ADMIXTURE. Generalized multifactor dimensionality reduction software was used to investigate epistatic interactions. Considering rs307355 ( TAS1R3) in the additive effect, the genotype TT was associated with the high decayed trajectory group (odds ratio [OR] = 4.52; 95% confidence interval [CI], 1.15–17.74) and the high missing trajectory group (OR = 3.35; 95% CI, 1.09–10.26). In the dominant effect, the genotype CT/TT was associated with the high decayed trajectory group (OR = 1.64; 95% CI, 1.14–2.35). Allele T was associated with an increased odds of 64% (OR = 1.64; 95% CI, 1.20–2.25) for the decayed component and 41% (OR = 1.41; 95% CI, 1.04–1.92) for the missing component. No associations were observed between rs307355 ( TAS1R3) and the filled component. rs35874116 ( TAS1R2) was not associated with DMF-T components. Positive epistatic interactions were observed involving rs307355 ( TAS1R3) and rs35874116 ( TAS1R2) with the decayed component (OR = 1.72; 95% CI, 1.04–2.84). Thus, rs307355 ( TAS1R3) genotypes and alleles seem positively associated with the trajectory of decayed and missing components in the life course. Epistatic interaction between rs307355 and rs35874116 may increase the decayed caries trajectory.

show abstract

Section: Discussioncontrasting

confidence: 84%

Sweet Taste Receptor Gene and Caries Trajectory in the Life Course

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Each “yes” answer corresponds to one score, so the sum of the scores will be between 0 and 9 for each study (question 6 was not applicable for this study). Based on Chisini et al's study [ 28 ], points were totaling as follows: 0–3: low quality 4–6: medium quality 7–9: high quality …”

Section: Methodsmentioning

confidence: 99%

Application of Digital Games for Speech Therapy in Children: A Systematic Review of Features and Challenges

Saeedi

Bouraghi

Seifpanahi

et al. 2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

Introduction. Treatment of speech disorders during childhood is essential. Many technologies can help speech and language pathologists (SLPs) to practice speech skills, one of which is digital games. This study aimed to systematically investigate the games developed to treat speech disorders and their challenges in children. Methods. A comprehensive search was conducted in four databases, including Medline (through PubMed), Scopus, Web of Science, and IEEE Xplore, to retrieve English articles published by July 14, 2021. The articles in which a digital game was developed to treat speech disorders in children were included in the study. Then, the features of the designed games and their challenges were extracted from the studies. Results. After reviewing the full texts of 69 articles and assessing them in terms of inclusion and exclusion criteria, 27 articles were included in the systematic review. In these articles, 59.25% of the games had been developed in English language and children with hearing impairments had received much attention from researchers compared to other patients. Also, the Mel-Frequency Cepstral Coefficients (MFCC) algorithm and the PocketSphinx speech recognition engine had been used more than any other speech recognition algorithm and tool. In terms of the games, 48.15% had been designed in a way that children could practice with the help of their parents. The evaluation of games showed a positive effect on children’s satisfaction, motivation, and attention during speech therapy exercises. The biggest barriers and challenges mentioned in the studies included sense of frustration, low self-esteem after several failures in playing games, environmental noise, contradiction between games levels and the target group’s needs, and problems related to speech recognition. Conclusion. The results of this study showed that the games positively affect children’s motivation to continue speech therapy, and they can also be used as the SLPs’ aids. Before designing these tools, the obstacles and challenges should be considered, and also, the solutions should be suggested.

show abstract

“…Other studies [28,[36][37][38]52] corroborate our findings in both types of dentition for SNP in TFIP11 (rs134136). Nevertheless, in a recent meta-analysis [62], the T allele of SNP in TFIP11 (rs134136) was found to be a risk factor. The meta-analysis, however, included patients without distinguishing between permanent and primary dentition, and it is, therefore, not possible to draw any conclusions specific to any type of dentition.…”

Section: Discussionmentioning

confidence: 96%

Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case–control study

et al. 2022

View full text Add to dashboard Cite

Objectives Dental caries is a widespread multifactorial disease, caused by the demineralization of hard dental tissues. Susceptibility to dental caries is partially genetically conditioned; this study was aimed at finding an association of selected single nucleotide polymorphisms (SNPs) in genes encoding proteins involved in amelogenesis with this disease in children. Materials and methods In this case–control study, 15 SNPs in ALOX15, AMBN, AMELX, KLK4, TFIP11, and TUFT1 genes were analyzed in 150 children with primary dentition and 611 children with permanent teeth with/without dental caries from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) cohort. Results Dental caries in primary dentition was associated with SNPs in AMELX (rs17878486) and KLK4 (rs198968, rs2242670), and dental caries in permanent dentition with SNPs in AMELX (rs17878486) and KLK4 (rs2235091, rs2242670, rs2978642), (p ≤ 0.05). No significant differences between cases and controls were observed in the allele or genotype frequencies of any of the selected SNPs in ALOX15, AMBN, TFIP11, and TUFT1 genes (p > 0.05). Some KLK4 haplotypes were associated with dental caries in permanent dentition (p ≤ 0.05). Conclusions Based on this study, we found that although the SNPs in AMELX and KLK4 are localized in intronic regions and their functional significance has not yet been determined, they are associated with susceptibility to dental caries in children. Clinical relevance AMELX and KLK4 variants could be considered in the risk assessment of dental caries, especially in permanent dentition, in the European Caucasian population.

show abstract

Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis

Cited by 15 publications

References 54 publications

Sweet Taste Receptor Gene and Caries Trajectory in the Life Course

Sweet Taste Receptor Gene and Caries Trajectory in the Life Course

Application of Digital Games for Speech Therapy in Children: A Systematic Review of Features and Challenges

Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case–control study

Contact Info

Product

Resources

About