Genes of Predisposition to Rheumatoid Arthritis

Nikulina, S. Yu.; Чернова, А. А.; Bolshakova, T Yu; Fok, Yu.V.; Orlova, N. М.

doi:10.20333/25000136-2014-3-11-18

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…Ревматоидный артрит является мультифакторным заболеванием, вклад генетических факторов составляет 40 %, факторов внешней среды -60 %. По данным генеалогических исследований, среди родственников первой степени родства больных ревматоидным артритом распространенность тяжелых форм заболевания примерно в четыре раза выше, чем среди населения в целом [19]. Основным прогностическим маркером ревматоидного артрита является ген HLA-DRB1, картированный на коротком плече хромосомы 6 (6q21.3) [20].…”

Section: Introductionunclassified

“…Носительство мутации гена НLА-DR4 выявляется у 70 % больных ревматоидным артритом и лишь у 28 % здоровых лиц. Также отмечается вклад генов провоспалительных цитокинов -ИЛ-1 и фактора некроза опухоли α (ФНОα) [19].…”

Section: Introductionunclassified

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Dermatoglyphs of Patients Suffering From Rheumatic Diseases of Various Etiologies

Nechaeva

Калаев

Gosteva

et al. 2021

Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry

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Mutations and genetic diseases, caused by genome disorders, frequently manifest at the phenotypic level and, especially, at the dermatoglyphic level, that makes it possible to use dermatoglyphs as markers of any genetic diseases. Rheumatic diseases is a group of disorders, characterized by systemic conjunctive tissue damage, essentially, connected with immune system pathology. Systemic progressive disorganization of conjunctive tissue is morphological base for the whole group of rheumatic diseases. Rheumatoid arthritis and ankylosing spondylitis are multifactorial and difficult-to-diagnose in the early stages diseases, that indicates the need to identify markers, that allows to detect these diseases as early as possible. A special role in the pathogenesis of these diseases is assigned to the genetic component, while recent studies have highlighted the shares of genetic determination in the disease’s advance are somewhat differ. The goal of this research was to identify the features of dermatoglyphic patterns of patients with rheumatoid arthritis and ankylosing spondylitis. Finger dermatoglyphic drawings of patients suffering from ankylosing spondylitis, rheumatoid arthritis, and representatives of the general population sample were studied. Statistical data processing was performed using non-parametric Van der Waerden test. To establish predictors of these diseases, ROC analysis was used. In persones suffering from ankylosing spondylitis there were found more differences in finger patterns from the control group, than in patients with rheumatoid arthritis. So, the total ridge count and the intensity index of the patterns on the left arm of patients with ankylosing spondylitis were lower than in the control group. Peoples with ankylosing spondylitis had more predictors of pathology than patients with rheumatoid arthritis. The analysis of the results shows that the absence of radial loops on the right arm and double loops in the examined persons may indicate the probability of developing these diseases. All predictors of rheumatoid arthritis and ankylosing spondylitis were characterized by high sensitivity and low specificity, which makes them convenient markers for preliminary screening studies and the formation of risk groups for the development of these pathologies. However, it is not recommended to use these predictors for establishing a final diagnosis, since their low specificity will cause to a large number of false-positive results among the examined persons. Individuals with ankylosing spondylitis have more differences in fingerprints from the control group and more predictors of pathology than patients with rheumatoid arthritis. It can be assumed that the genetic component plays a more significant role in the pathogenesis of ankylosing spondylitis, and the formation of rheumatoid arthritis is more caused by environmental factors. Our study confirms the feasibility of considering dermatoglyphs as an additional genetic marker in clinical medicine. Dermatoglyphic indicators can be used in the formation of risk groups for inflammatory joint diseases for primary prevention, for solving a number of issues of medical and genetic consulting, which indicates the prospects of this research area.

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Section: Introductionunclassified

Dermatoglyphs of Patients Suffering From Rheumatic Diseases of Various Etiologies

Nechaeva

Калаев

Gosteva

et al. 2021

Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry

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“…Заболевание характеризуется упорным прогрессирующим течением, которое в отсутствие адекватного лечения приводит к нарушению функций опорнодвигательного аппарата и к инвалидизации больного. Так, в первые 3 года болезни трудоспособность теряют примерно 35% больных, а через 5 лет -более половины [4,7].…”

Section: Introductionunclassified

Proinflammatory Cytokines in Rheumatoid Arthritis: Relationship With Vitamin D Deficiency

Huseynova¹,

Hajiyev²,

Efendiyev³

et al. 2018

Theoretical & Applied Science

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“…1 The role of genetic factors in the development of the disease has been is confirmed by various studies on immune genetics. [2][3][4] It is estimated that about 40% of the total genetic component of RA refers to the major histo compatibility complex the HLA system. 5 A detailed analysis of the associations of RA with the HLA system suggests that HLA alleles are associated not only with sensitivity but also with the protection (resistant) from the development of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…According to the literature, in European population Association established rheumatoid arthritis adults with the genes of the Gene locus DRB1 *01, *03, *04. 2,3 The aim of our work was to identify similarities in the pathogenesis of RA and autoimmune thyroid disease to determine the cause of the very frequent thyroid lesions in RA.…”

Section: Introductionmentioning

confidence: 99%

Genetic factors: influence on the development of thyroid diseases and rheumatic diseases

Ov¹

2018

EMIJ

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The article discusses the presence of common genes in RA and thyroid disease.Methods: Published studies that enrolled adult patients with rheumatoid arthritis (RA) and autoimmune thyroid pathology were identified by searches of Medline and Embase, and by manual searches of medical journals. Meta-analyses were performed to assess the association of SE presence, dose, and genotype with rheumatoid arthritis and autoimmune thyroid pathology.Results: A total of studies 133 patients were included in the analysis. RA patients have increase in the frequency of the Gene DR B1 (p<0.05, OR=3, 2, 95% CI=1, 4-6, 8), the gene B8 (p<0.05, RR=2, 6; 95% CI=1, 8-4, 3). In patients with autoimmune thyroid disease, most frequently found genes HLA-B8 (94% patients) HLA-DR3 (67%) and HLA-DR5 (72%). Conclusion:According to the obtained results it is concluded that the presence of the HLA -B8 gene can cause of RA in patients with autoimmune thyroid pathology.

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Genes of Predisposition to Rheumatoid Arthritis

Cited by 5 publications

References 3 publications

Dermatoglyphs of Patients Suffering From Rheumatic Diseases of Various Etiologies

Dermatoglyphs of Patients Suffering From Rheumatic Diseases of Various Etiologies

Proinflammatory Cytokines in Rheumatoid Arthritis: Relationship With Vitamin D Deficiency

Genetic factors: influence on the development of thyroid diseases and rheumatic diseases

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