Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees

Yoshimasu, Kouichi; Mure, Kanae; Hashimoto, Marowa; Takemura, Shigeki; Tsuno, Kanami; Hayashida, Miyeko; Kinoshita, Kenji; Takeshita, Tatsuya; Miyashita, Kazuhisa

doi:10.1016/j.drugalcdep.2014.11.034

Cited by 19 publications

(11 citation statements)

References 36 publications

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“…For example, using the MR approach, Irons and colleagues () found that alcohol use was not the cause of adolescent delinquency. Another study (Yoshimasu et al., ) investigating the relationship between the ALDH2 rs671 polymorphism and depression and anxiety among Japanese adults found no significant correlation between the gene and the 2 internalizing problems. In fact, several previous studies provided evidence supporting the opposite direction of the causal relationship.…”

Section: Discussionmentioning

confidence: 96%

The Causal Role of Alcohol Use in Adolescent Externalizing and Internalizing Problems: A Mendelian Randomization Study

Chao

McGue

2017

Alcoholism Clin & Exp Res

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Section: Discussionmentioning

confidence: 96%

The Causal Role of Alcohol Use in Adolescent Externalizing and Internalizing Problems: A Mendelian Randomization Study

Chao

McGue

2017

Alcoholism Clin & Exp Res

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“…13 A similar example is the recent linking (in 2015) of genetic polymorphisms of both alcohol dehydrogense-1B and acetaldehyde dehydrogenase-2, the gene products of which influence alcohol metabolism, with depression and anxiety in Japanese workers. 14 The power of deep literature analysis for biomarker identification is illustrated by tracking the evolution of an association between MIR30E and schizophrenia. In 2012, a review article reported that miR-30e was shown to alter expression in the same direction in two or more studies of postmortem gray matter of individuals with schizophrenia.…”

Section: Biomarker Use Casementioning

confidence: 99%

Advanced literature analysis in a Big Data world

Cheadle

Cao²,

Kalinin³

et al. 2016

Annals of the New York Academy of Sciences

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Comprehensive data mining of the scientific literature has become an increasing challenge. To address this challenge, Elsevier's Pathway Studio software uses the techniques of natural language processing to systematically extract specific biological information from journal articles and abstracts that is then used to create a very large, structured, and constantly expanding literature knowledgebase. Highly sophisticated visualization tools allow the user to interactively explore the vast number of connections created and stored in the Pathway Studio database. We demonstrate the value of this structured information approach by way of a biomarker use case example and describe a comprehensive collection of biomarkers and biomarker candidates, as reported in the literature. We use four major neuropsychiatric diseases to demonstrate common and unique biomarker elements, demonstrate specific enrichment patterns, and highlight strategies for identifying the most recent and novel reports for potential biomarker discovery. Finally, we introduce an innovative new taxonomy based on brain region identifications, which greatly increases the potential depth and complexity of information retrieval related to, and now accessible for, neuroscience research.

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“…Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are two important enzymes for ethanol metabolism in the human body (Asakage et al, 2007;Dakeishi et al, 2008;Kang et al, 2009;Lee et al, 2015). ADH1B and ALDH2 are two common ADH and ALDH proteins, and polymorphisms in ADH1B rs1229984 and ALDH2 rs671 could cause alterations in enzymatic activities of these proteins, thus leading to the development of nervous system diseases including Alzheimer's disease (Song et al, 2014;Hu et al, 2015;Yoshimasu et al, 2015;Zhang et al, 2015). Therefore, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

Ma¹,

Lu²

2016

Genet. Mol. Res.

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In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer's disease (OR = 2.54, 95%CI = 1.19-5.41). In addition, ADH1B rs1229984 was also associated with elevated risk of Alzheimer's disease in both dominant (OR = 1.78, 95%CI = 1.09-2.93) and recessive (OR = 2.33, 95%CI = 1.18-4.57) models. For ALDH2 rs671, the AA genotype was correlated with an increased risk of Alzheimer's disease as compared to the GG genotype (OR = 4.57, 95%CI = 1.60-14.01). The ALDH2 rs671 polymorphism was associated with Alzheimer's in both dominant (OR = 1.79, 95%CI = 1.08-2.97) and recessive (OR = 4.17, 95%CI = 1.49-12.67) models. In conclusion, we observed that ADH1B rs1229984 and ALDH2 rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.

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Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees

Cited by 19 publications

References 36 publications

The Causal Role of Alcohol Use in Adolescent Externalizing and Internalizing Problems: A Mendelian Randomization Study

The Causal Role of Alcohol Use in Adolescent Externalizing and Internalizing Problems: A Mendelian Randomization Study

Advanced literature analysis in a Big Data world

Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

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