West Nile virus (WNV) is a vector‐borne disease spread primarily between birds and mosquitoes. In the United States, the main methods used to control WNV are aimed at lowering the vector population through reducing births (larvicide) or increasing the mortality of adults (adulticide). We investigate the potential of a novel control, vaccination of newborn birds (nestlings). We first apply standard optimal control (OC) methodology to a nonautonomous differential equation model for WNV transmission incorporating avian stage structure and allowing larvicide, adulticide, and nestling vaccination. We convert the continuous OC results to practical advice that accounts for restrictions on the frequency of control application in the field. We then develop an alternative optimization algorithm using genetic algorithms and compare control advice for various budget constraints. We find that vaccination is recommended, provided budgets are sufficiently high, and explore how differences in control efficacy and vector biting rates on host stages affect our results.
Recommendations for Resource Managers:
Genetic algorithms are able to incorporate practical restrictions on control application as well as budget constraints. Advice depends on the efficacies of controls as well as model parameters.
At high‐efficacy estimates, adulticide is recommended for low budgets. Vaccination is recommended when budgets are sufficiently high, and sooner for scenarios where nestling hosts have increased vector exposure.
If vector control has low efficacy and nestlings have increased vector exposure relative to older hosts, including vaccination may reduce levels of infectious mosquitoes below those resulting from high‐efficacy vector control alone.