Genetic analysis of influenza A virus (H5N1) derived from domestic cat and dog in Thailand

Amonsin, Alongkorn; Songserm, Taweesak; Chutinimitkul, Salin; Jam-on, Rungroj; Sae-Heng, Namdee; Pariyothorn, Nuananong; Payungporn, Sunchai; Theamboonlers, Apiradee; Poovorawan, Yong

doi:10.1007/s00705-007-1010-5

Cited by 53 publications

(38 citation statements)

References 19 publications

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“…Investigations also indicate virus transmission to dogs. A fatal infection was documented in Thailand (5,6). In central Thailand, seroprevalence of ≈25% among 629 village dogs was reported (7).…”

Section: H Ighly Pathogenic Avian Infl Uenza (Hpai) Virus (H5n1)mentioning

confidence: 99%

Experimental Infection and Natural Contact Exposure of Dogs with Avian Influenza Virus (H5N1)

Giese

Harder

Teifke

et al. 2008

Emerg. Infect. Dis.

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Section: H Ighly Pathogenic Avian Infl Uenza (Hpai) Virus (H5n1)mentioning

confidence: 99%

Experimental Infection and Natural Contact Exposure of Dogs with Avian Influenza Virus (H5N1)

Giese

Harder

Teifke

et al. 2008

Emerg. Infect. Dis.

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“…Since then the virus has spread across Asia to Russia, the Middle East, Europe, and Africa, causing deaths in wild aquatic birds (13,58,71,81), domestic ducks and chickens (29,39,43), dogs and cats (2,35,36,55,76), and 254 of 405 confirmed human cases as of 5 February 2009 according to the World Health Organization (http://www.who.int/csr/disease /avian_influenza/).…”

mentioning

confidence: 99%

Detection of Mammalian Virulence Determinants in Highly Pathogenic Avian Influenza H5N1 Viruses: Multivariate Analysis of Published Data

Lycett

Ward

Lewis

et al. 2009

J Virol

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Highly pathogenic avian influenza (HPAI) virus H5N1 infects water and land fowl and can infect and cause mortality in mammals, including humans. However, HPAI H5N1 strains are not equally virulent in mammals, and some strains have been shown to cause only mild symptoms in experimental infections. Since most experimental studies of the basis of virulence in mammals have been small in scale, we undertook a metaanalysis of available experimental studies and used Bayesian graphical models (BGM) to increase the power of inference. We applied text-mining techniques to identify 27 individual studies that experimentally determined pathogenicity in HPAI H5N1 strains comprising 69 complete genome sequences. Amino acid sequence data in all 11 genes were coded as binary data for the presence or absence of mutations related to virulence in mammals or nonconsensus residues. Sites previously implicated as virulence determinants were examined for association with virulence in mammals in this data set, and the sites with the most significant association were selected for further BGM analysis. The analyses show that virulence in mammals is a complex genetic trait directly influenced by mutations in polymerase basic 1 (PB1) and PB2, nonstructural 1 (NS1), and hemagglutinin (HA) genes. Several intra-and intersegment correlations were also found, and we postulate that there may be two separate virulence mechanisms involving particular combinations of polymerase and NS1 mutations or of NS1 and HA mutations.

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“…As of 1997, H3N2 circulates in pigs (Gramer et al 2007). Horses have been infected with H7N7 and H3N8 viruses (Amonsin et al 2007;Oxburgh and Hagström 1999). The latter can also infect and kill canines.…”

Section: Epizootics and Panzooticsmentioning

confidence: 99%

Pandemic Influenza Vaccines

DiMenna

Ertl

2009

Current Topics in Microbiology and Immunology

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Since their compositions remain uncertain, universal pandemic vaccines are yet to be created. They would aim to protect globally against pandemic influenza viruses that have not yet evolved. Thus they differ from seasonal vaccines to influenza virus, which are updated annually in spring to incorporate the latest circulating viruses, and are then produced and delivered before the peak influenza season starts in late fall and winter. The efficacy of seasonal vaccines is linked to their ability to induce virus-neutralizing antibodies, which provide subtype-specific protection against influenza A viruses. If pandemic vaccines were designed to resemble current vaccines in terms of composition and mode of action, they would have to be developed, tested, and mass-produced after the onset of a pandemic, once the causative virus had been identified. The logistic problems of generating a pandemic vaccine from scratch, conducting preclinical testing, and producing billions of doses within a few months for global distribution are enormous and may well be insurmountable. Alternatively, the scientific community could step up efforts to generate a universal vaccine against influenza A viruses that provides broadly cross-reactive protection through the induction of antibodies or T cells to conserved regions of the virus.

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Genetic analysis of influenza A virus (H5N1) derived from domestic cat and dog in Thailand

Cited by 53 publications

References 19 publications

Experimental Infection and Natural Contact Exposure of Dogs with Avian Influenza Virus (H5N1)

Experimental Infection and Natural Contact Exposure of Dogs with Avian Influenza Virus (H5N1)

Detection of Mammalian Virulence Determinants in Highly Pathogenic Avian Influenza H5N1 Viruses: Multivariate Analysis of Published Data

Pandemic Influenza Vaccines

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