1998
DOI: 10.1038/bjc.1998.445
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Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity in the FHIT locus

Abstract: Summary Lung cancer is strictly associated with tobacco smoking. Tumours developed in non-smoking subjects account for less than 10% of all lung cancers and show peculiar histopathlIogical features, being prevalentty adenocarcinomas. A number of genetic data suggest that their biological behaviour may be different from that of lung tumours caused by smoking, however the number of cases investigated to date is too low to draw definitive conclusions. We have examined the status of p53 and K-ras genes and the pre… Show more

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Cited by 38 publications
(23 citation statements)
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“…Taken together, these results provide a direct link between specific genetic alterations and exposure to tobacco carcinogens. As in the reports mentioned before (Marchetti et al, 1998;Geradts et al, 2000), Fhit expression was not correlated to the abnormality of p53 in smoking patients. A recent study (Zienolddiny et al, 2001) indicated that LOH at 3p, 5q, 9p, 11p, and 17p regions were interdependent and highly associated with mutated TP53 gene in smokers.…”
Section: Discussionsupporting
confidence: 70%
See 1 more Smart Citation
“…Taken together, these results provide a direct link between specific genetic alterations and exposure to tobacco carcinogens. As in the reports mentioned before (Marchetti et al, 1998;Geradts et al, 2000), Fhit expression was not correlated to the abnormality of p53 in smoking patients. A recent study (Zienolddiny et al, 2001) indicated that LOH at 3p, 5q, 9p, 11p, and 17p regions were interdependent and highly associated with mutated TP53 gene in smokers.…”
Section: Discussionsupporting
confidence: 70%
“…The genomic status of FHIT and TP53 genes has been investigated in a series of lung cancers. Deletions at the chromosomal region 3p14.2 and TP53 abnormalities were present in 20% of the cases and the alterations were constantly associated (Marchetti et al, 1998). Recently, it was reported that alterations in the FHIT locus detected by DNA and/ or reverse transcription -PCR analysis correlated with a loss of Fhit protein expression in lung, cervical, and breast carcinomas (Greenspan et al, 1997;Sozzi et al, 1997b;Campiglio et al, 1999).…”
Section: Discussionmentioning
confidence: 99%
“…For example, it was found that somatic p53 mutations occur more frequently in SCC than in AC [34]. In addition, individuals with AC and p53 somatic mutations have a shorter survival compared with SCC [30], and both LOH and somatic mutation patterns of the P53 gene among AC and SCC patients are distinctly different [35]. In another study, comparing gene expression profiles by microarray analysis demonstrated that different subtypes of NSCLCs exhibit substantially different molecular signatures which recapitulate distinctive lung developmental pathways known to be associated with respective subtypes [3].…”
Section: Discussionmentioning
confidence: 99%
“…For example, Ͼ50% of NSCLCs have been found to carry p53 mutations (11) and 50 -70% of NSCLCs also have deficient FHIT gene expression (28,29). In addition, several studies have demonstrated that an allelic imbalance within the FHIT locus frequently coexists with p53 abnormalities and that this may be an early event in NSCLC pathogenesis (30,31). From a clinical perspective, NSCLCs are highly resistant to conventional treatments such as surgery, radiotherapy, and chemotherapy (32).…”
Section: Discussionmentioning
confidence: 99%