Genetic Analysis of PSORS1 Distinguishes Guttate Psoriasis and Palmoplantar Pustulosis

Asumalahti, Kati; Ameen, Mahreen; Suomela, Sari; Hagforsen, Eva; Michaëlsson, G; Evans, Julie; Munro, M; Veal, Colin; Allen, Michael; Leman, Joyce; Burden, David; Kirby, Brian; Connolly, Maureen; Griffiths, C.E.M.; Trembath, Richard C.; Kere, Juha; Saarialho-Kere, U; Barker, Jonathan

doi:10.1046/j.1523-1747.2003.12094.x

Cited by 208 publications

(153 citation statements)

References 36 publications

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“…92 -The incidence of HLA B 13 , BW 17 or BW 35 is not increased in patients with palmoplantar pustulosis as compared with controls (unlike what happens in psoriasis). 63 -PPP has been associated with tumor necrosis factor B (TNFB) gene polymorphism and psoriasis, with TNFA gene polymorphism.…”

Section: Clinical Manifestations Histopathological Aspects and Complmentioning

confidence: 93%

Dermatoses neutrofílicas: parte II

Razera

Olm

Bonamigo

2011

An. Bras. Dermatol.

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This article addresses neutrophilic dermatoses, thus complementing the previous article (part I). The following dermatoses are introduced and discussed: subcorneal pustular dermatosis (Sneddon-Wilkinson disease), dermatitis cruris pustulosa et atrophicans, acute generalized exanthematous pustulosis, continuous Hallopeau acrodermatitis, palmoplantar pustulosis, infantile acropustulosis, Andrews' pustular bacteride and eosinophilic pustular folliculitis. A brief review of neutrophilic dermatoses in pediatric patients is also conducted. Keywords: Neutrophil infiltration; Pediatrics; Skin diseases Resumo: Neste artigo são abordadas as dermatoses neutrofílicas, complementando o artigo anterior (parte I). São apresentadas e comentadas as seguintes dermatoses: pustulose subcórnea de SneddonWilkinson, dermatite crural pustulosa e atrófica, pustulose exantemática generalizada aguda, acrodermatite contínua de Hallopeau, pustulose palmoplantar, acropustulose infantil, bacteride pustular de Andrews e foliculite pustulosa eosinofílica. Uma breve revisão das dermatoses neutrofílicas em pacientes pediátricos também é realizada. Palavras-chave: Dermatopatias; Infiltração de neutrófilos; Pediatria

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Section: Clinical Manifestations Histopathological Aspects and Complmentioning

confidence: 93%

Dermatoses neutrofílicas: parte II

Razera

Olm

Bonamigo

2011

An. Bras. Dermatol.

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“…Approximately 25% of cases are allied with common psoriasis vulgar, but it is now assumed that palmoplantar pustulosis may not be a form of psoriasis 10 . This termination is derived from genetic studies showing no group with Human Leukocyte Antigen (HLA) Cw6 on chromosome 6p which are correlated to chronic plaque and guttate psoriasis 11 .…”

Section: Palmoplantar Pustulosismentioning

confidence: 99%

Current Trends in Treatment and Management of Psoriasis: An Updated Review

Cherukuri¹,

Vuppalapati²,

Narayanan³

et al. 2018

Int. Res. J. Pharm.

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Psoriasis is a proliferative autoimmune skin disease which is affecting 2% of worldwide population. It is characterized by itching, skin rashes and red scalps with white scales on the skin. Though, different types are reported, common existing form of psoriasis is plaque psoriasis. The epidemiology of disease seems to be remains unknown, but the incidence varies, surrounded by the different countries. The pathophysiology of the disease appears as drastic cellular changes occur both in epidermis and dermis which narrates to keratinocyte hyperproliferation. Earlier available medications like emollients and some keratolyitic agents has not proven promising role in controlling the disease burden. But, in advance regimen, with wide range of therapeutic mediators like coal tar, anthranilin, calcineurin inhibitors, methotrexate, retinoids, cyclosporine are proven to be effective in treating mild psoriasis to severe psoriasis. In recent years, phototherapy has once again emerged as most recommended due to ease of treatment and its intoxications. Hence, this review emphasizes the therapeutic agents available in market and its effectiveness in controlling the psoriasis.

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“…Even a bimodal immunopathology theory proposes that psoriasis is initiated by IL-1/ Th17-dominated responses [48]. In addition to the well-known association of preceding pharyngitis episode, gutate psoriasis onset is mostly conined to individuals carrying the HLA-Cw6 allele [49], a genetic risk factor for early psoriasis. Interestingly, when immune responses from gutate psoriasis samples were classiied according with the simultaneous presence of both genetic and environmental factors, that is HLA-Cw6 allele and a prior pharyngitis episode, respectively, the Th17-associated response was higher than that exerted by samples from the other "nonpredisposed" gutate psoriatic individuals.…”

Section: Streptococcus Pyogenes: An Innate Trigger That Induces Il-17mentioning

confidence: 99%

Human Translational Research in Psoriasis Using CLA+ T Cells

Ruiz-Romeu¹,

Santamaria‐Babí²

2017

An Interdisciplinary Approach to Psoriasis

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Focusing on the study of human memory CLA+ T cells to understand psoriasis pathology constitutes an innovative approach to explore the pathological mechanism of this chronic cutaneous inlammatory disease. CLA+ T cells can be considered peripheral cell biomarkers in the study of T-cell mediated human skin diseases. During the last few years, new evidences have been found that link streptococcal infection with IL-17 response in psoriasis by studying the interaction between Streptococcus pyogenes with CLA+ T cells and autologous epidermal cells. S. pyogenes constitutes the best clinically characterized trigger of psoriasis and by exploring its efect on CLA+ T cells and epidermal cells in psoriasis may allow understanding psoriasis by using patient's clinical samples ex vivo. Keywords: psoriasis, CLA+ T cells, translational research, Streptococcus pyogenes, IL17 CLA+ T cells and the regional cutaneous immune systemThe adaptive immune responses taking place during cutaneous chronic inlammation in psoriasis preferentially involve a subset of memory T lymphocytes, which are related to the skin and that belong to the cutaneous immune system, and constitute one of the best characterized regional immune systems of the body and known for decades [1]. In the humans, the cutaneous lymphocyte-associated antigen (CLA) is a surface cell marker that allows identifying T cells that belong to the cutaneous immune system. The CLA antigen is a carbohydrate expressed by 15% of human circulating T cells, and on most (>90%) skin-iniltrating T cells, contrary to other inlamed organs [2]. CLA is expressed preferentially on memory antigenexperienced T cells.© 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The CLA is one of the adhesion molecule that, together with chemokine receptors, allows T cells to selectively migrate to the skin, in either homeostatic or inlammatory conditions, by binding to endothelial cell wall via adhesion molecules or ligands. The molecular interactions between CLA/E-selectin, very late antigen-4 (VLA-4)/vascular cell adhesion protein-1 (VCAM-1), lymphocyte function-associated antigen-1 (LFA-1)/intercellular adhesion molecule-1 (ICAM-1), and chemokine ligands for chemokine, C-C motif receptor (CCR) 10, CCR4, CCR6, and CCR8 constitute a code bar system enabling skin iniltration [3].The importance of circulating CLA+ T cells for understanding the skin immune system is not only based on their capacity to selectively migrate to skin, but also on the fact that these circulating memory T cells are functionally related to the immune response taking place in the cutaneous inlamed lesions. This feature is based on the recirculating capacity of those cells between lesional skin and blood during cutaneous inlammation in psoriasis [3]. The adhesive interaction between LFA-1 ...

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Genetic Analysis of PSORS1 Distinguishes Guttate Psoriasis and Palmoplantar Pustulosis

Cited by 208 publications

References 36 publications

Dermatoses neutrofílicas: parte II

Dermatoses neutrofílicas: parte II

Current Trends in Treatment and Management of Psoriasis: An Updated Review

Human Translational Research in Psoriasis Using CLA+ T Cells

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