Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

Blanton, Ronald E.; Silva, Luciano K.; Morato, Vanêssa; Parrado, Antonio; Dias, Juarez Pereira; Melo, Paulo Roberto Santana de; Reis, Eliana A. G.; Goddard, Katrina A.B.; Nunes, Márcio Roberto Teixeira; Rodrigues, Sueli Guerreiro; Vasconcelos, Pedro F. C.; Castro, Jesuina M.; Reis, Mitermayer Galvão dos; Barreto, Maurício L.; Teixeira, Maria Glória

doi:10.1038/ejhg.2008.4

Cited by 67 publications

(81 citation statements)

References 14 publications

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“…Race, an important variable that interferes with dengue severity 33,34 and possibly with the persistence of symptoms, was not taken into account because a precise race discrimination is very difficult to perform with the Brazilian population due to its high level of admixture.…”

Section: Discussionmentioning

confidence: 99%

Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study

Tristão-Sá

Kubelka

Zandonade

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction:To analyze the liver dysfunction and evolution of signs and symptoms in adult dengue patients during a two-month follow-up period. Methods: A prospective cohort study was conducted in Campos dos Goytacazes, Rio de Janeiro, Brazil, from January to July, 2008. The evolution of laboratory and clinical manifestations of 90 adult dengue patients was evaluated in five scheduled visits within a two-month follow-up period. Twenty controls were enrolled for the analysis of liver function. Patients with hepatitis B, hepatitis C, those known to be human immunodeficiency virus (HIV) seropositive and pregnant women were excluded from the study. Results: At the end of the second month following diagnosis, we observed that symptoms persisted in 33.3% (30/90) of dengue patients. We also observed that, 57.7% (15/26) of the symptoms persisted at the end of the second month. The most persistent symptoms were arthralgia, fatigue, weakness, adynamia, anorexia, taste alteration, and hair loss. Prior dengue virus (DENV) infection did not predispose patients to a longer duration of symptoms. Among hepatic functions, transaminases had the most remarkable elevation and in some cases remained elevated up to the second month after the disease onset. Alanine aminotransferase (ALT) levels overcame aspartate aminotransferase (AST) during the convalescent period. Male patients were more severely affected than females. Conclusions: Dengue fever may present a wide number of symptoms and elevated liver transaminases at the end of the second month.

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Section: Discussionmentioning

confidence: 99%

Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study

Tristão-Sá

Kubelka

Zandonade

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…However, when only severe cases of dengue (DHF and DSS), classifi ed according to the WHO criteria, were used as 20,21 . In contrast, at the ecological level, our fi ndings indicate a higher risk of severe dengue in districts with a higher percentage of self-declared black residents.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of severe dengue in Rio de Janeiro: an ecological study

Gibson

Souza-Santos

Siqueira

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction:This study aimed to analyze the relationship between the incidence of severe dengue during the 2008 epidemic in Rio de Janeiro, Brazil, and socioeconomic indicators, as well as indicators of health service availability and previous circulation of the dengue virus serotype-3 (DENV-3). Methods: In this ecological study, the units of analysis were the districts of Rio de Janeiro. The data were incorporated into generalized linear models, and the incidence of severe dengue in each district was the outcome variable. Results: The districts with more cases of dengue fever in the 2001 epidemic and a higher percentage of residents who declared their skin color or race as black had higher incidence rates of severe dengue in the 2008 epidemic [incidence rate ratio (IRR)= 1.21; 95% confi dence interval ( 95% CI)= 1.05-1.40 and IRR= 1.34; 95% CI= 1.16-1.54, respectively]. In contrast, the districts with Family Health Strategy (FHS) clinics were more likely to have lower incidence rates of severe dengue in the 2008 epidemic (IRR= 0.81; 95% CI= 0.70-0.93). Conclusions: At the ecological level, our fi ndings suggest the persistence of health inequalities in this region of Brazil that are possibly due to greater social vulnerability among the selfdeclared black population. Additionally, the protective effect of FHS clinics may be due to the ease of access to other levels of care in the health system or to a reduced vulnerability to dengue transmission that is afforded by local practices to promote health.

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“…Una posible explicación es el origen étnico de los pacientes. La ascendencia africana se ha asociado a la protección contra las formas graves de la enfermedad (25)(26)(27) y en la zona de estudio más del 90 % de la población es afrocolombiana y todos los pacientes lo eran. Las infecciones secundarias se asocian a una mayor aparición de formas complicadas (28)(29)(30).…”

Section: Discussionunclassified

Infección por dengue una causa frecuente de síndrome febril en pacientes de Quibdó, Chocó, Colombia

et al. 2014

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Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

Cited by 67 publications

References 14 publications

Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study

Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study

Occurrence of severe dengue in Rio de Janeiro: an ecological study

Infección por dengue una causa frecuente de síndrome febril en pacientes de Quibdó, Chocó, Colombia

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