Genetic and antigenic heterogeneity among feline calicivirus isolates from distinct disease manifestations

Geißler, Klaus; Schneider, K. T. M.; Platzer, G.; Truyen, Barbro; Kaaden, Oskar‐Rüger; Truyen, Uwe

doi:10.1016/s0168-1702(97)01440-8

Cited by 84 publications

(88 citation statements)

References 29 publications

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“…Phylogenetic analysis of nucleotide sequences mostly from the capsid gene results in a "star-like" phylogeny with little statistical support for sub-species clusters [31,33]. The only exception to this appears to be in viruses from Japan where there is some evidence for the presence of two genotypes [94], although the significance of this is not clear.…”

Section: Aetiologymentioning

confidence: 99%

“…There have been several attempts to identify consistent genetic and antigenic differences between FCV isolates from cats with LPGS and those from cats with other FCV-associated diseases, and these have met with variable results. Those based on sequencing and monoclonal antibodies have failed to identify consistent differences [31,33,65]. However, those based on polyclonal antisera reactivity have shown some differences between those isolates associated with chronic stomatitis and those associated with other diseases, which has been attributed to evolution of these FCV isolates in such chronically infected cats [19,79].…”

Section: Clinical Signsmentioning

confidence: 99%

“…However, interestingly, for the two VSD isolates so far sequenced, there is some suggestion that sequence differences lead to the acquisition of an extra glycosylation site in both cases [1,28]. This difficulty of identifying clear genomic markers for VSD is not without precedent for FCV, in that attempts to identify markers associated with lameness have also met with failure [31,33]. It therefore seems likely that any viral mutations associated with VSD are either subtle, or located in a different region of the genome to that sequenced to date, or indeed a combination of the two.…”

Section: Fcv-associated Virulent Systemic Diseasementioning

confidence: 99%

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Feline calicivirus

et al. 2007

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-Feline calicivirus (FCV) is an important and highly prevalent pathogen of cats. It belongs to the family Caliciviridae which includes other significant pathogens of man and animals. As an RNA virus, high polymerase error rates convey upon FCV a high genome plasticity, and allow the virus to respond rapidly to environmental selection pressures. This makes the virus very adaptable and has important implications for clinical disease and its control. Being genetically diverse, FCV is associated with a range of clinical syndromes from inapparent infections to relatively mild oral and upper respiratory tract disease with or without acute lameness. More recently, highly virulent forms of the virus have emerged associated with a systemic infection that is frequently fatal. A proportion of FCV infected cats that recover from acute disease, remain persistently infected. In such cats, virus evolution is believed to help the virus to evade the host immune response. Such longterm carriers may only represent a minority of the feline population but are likely to be crucial to the epidemiology of the virus. Vaccination against FCV has been available for many years and has effectively reduced the incidence of clinical disease. However, the vaccines do not prevent infection and vaccinated cats can still become persistently infected. In addition, FCV strain variability means that not all strains are protected against equally. Much progress has been made in understanding the biology and pathogenesis of this important feline virus. Challenges for the future will necessarily focus on how to control the variability of this virus particularly in relation to emerging virulent strains and vaccination.

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Section: Aetiologymentioning

confidence: 99%

Section: Clinical Signsmentioning

confidence: 99%

Section: Fcv-associated Virulent Systemic Diseasementioning

confidence: 99%

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Feline calicivirus

et al. 2007

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“…Area E, identified as a hypervariable region of the capsid protein, is probably responsible for the FCV antigenic variations. 1,11,13,32 It contains at least 1 neutralizing epitope. 12,40 The ORF3, which overlaps ORF2, (nucleotides 7617-7626 to 7634-7643), encodes a minor structural protein, VP2, with an unknown function.…”

Section: Introductionmentioning

confidence: 99%

“…Viruses recovered from cats with different clinical signs or from disparate geographic regions are genetically similar. 11,19,26 Genetic studies on the FCV capsid protein also suggest that only 1 genotype of FCV exists. 1,11,13,16 However, some data suggest antigenic clustering of the isolates producing similar clinical signs.…”

Section: Introductionmentioning

confidence: 99%

Genetic Analysis of Feline Caliciviruses Associated with a Hemorrhagic-Like Disease

2005

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Abstract. Feline calicivirus (FCV) is 1 of the most common causes of upper respiratory tract disease in cats. Other disease syndromes associated with FCV infection have been reported. Recently, calicivirus infection associated with a hemorrhagic-like disease leading to significant mortality in cats has been reported. The clinical signs are similar to those observed with the calicivirus of rabbit hemorrhagic disease. This study characterized 2 FCV isolates associated with hemorrhagic-like disease. Nucleotide sequencing of the complete genome has been done for these 2 isolates as well as for 4 additional isolates representing other disease syndromes. Previously reported sequence data for the entire genome of classical FCV (6 isolates) and a portion of the capsid gene for hemorrhagic-like FCV (3 isolates), isolated in different regions of United States were used in the genetic analysis. Sequence data were used to determine relationships among the isolates and any correlation with phenotype. Nucleotide sequence comparisons of the entire genome and individual open reading frames revealed high homology among all isolates. Data suggest that the virulence may have genetic determinants on the basis of phylogenetic clustering of the isolates associated with hemorrhagic-like disease.

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