Genetic and Bioinformatic Studies of Antidepressant Drug Therapeutic Efficacy and Toxicity: A Current Overview

Lu, Da-Yong; Lu, Ting-Ren; Che, Jin-Yu; Zhu, Peng

doi:10.2174/1574889810666150209103931

Cited by 8 publications

(25 citation statements)

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“…For computational work, the mathematics or physics major students must be smarter and adept over biomedical major students [21,22]. So it is foreseeable that mathematics or physics major students might be at lease parts of working force suitable for genomic sequencing.…”

Section: Genome-wide Association Study and New Techniquesmentioning

confidence: 99%

HIV in Human Genomes and Therapeutics

Lu¹,

Lü²,

Yarla³

et al. 2017

HIV Curr Res

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One of the most interesting topics in the field of HIV/AIDS study is the possible relationship between HIV genetic penetrations and disease stages. One decade before, this kind of genomic information is difficult to achieve. Yet, the innovations of next generation sequencing (NGS) have changed this landscape. At present, new generations of bio-therapies target this undesired pathogenic pathways. In this article, we address the relationships between HIV-induced genomic changes across the history and different types of therapeutics have been testified since last decade-including integrate inhibitors, genome editing agents and therapeutic schedules. Future perspectives are also given. HIV in Human Genomes and Therapeutics Knowledge EvolutionPhysical states of DNA polymers in pathologic and therapeutic studiesAt the beginning of this millennium, genomic drafting was a huge task hardly finished by single lab or even an institute. Owing to this situation, physical states of DNA samples were used to identify smallsegments of HIV genome integration into physical states of DNA polymers. In these initial studies, a great amount of HIV pieces can penetrate into DNA polymers as fast as 4 hrs [4]. By utility of this experimental model, a series of HIV/AIDS therapeutic agents (integrate inhibitors) have been developed and finally licensed [4-6,14-17].Since integrase inhibitors were usually developed by DNA polymer substrate techniques, the situation of clinical therapeutic improvements were uncertainty. It means that DNA polymer conditions are not completely parallel with complicate conditions in living cells and bodies-including HIV infected patients. As a result, more sophisticate living conditions (in vitro or in vivo experimental models) must be established, and even utilized as HIV therapeutic drug evaluating systems. Different types of animal models and human cell modelsBefore clinical human genomic pathological and therapeutic studies, in vitro or in vivo animal models for HIV genomic integration must be utilized first. In animal model studies, selections of animal genomic origin and human cell/tissue types are important.There are similarity and diversity among different animal genomic origins and human cell types. These types of animal/human genomic studies generally needs less ethical requirements and can be studied in repeat ways comparing with clinical human investigations. In our opinions, these types of HIV genomic penetration studies should be emphasized now and in future. Similarly, these types of HIV animal

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Section: Genome-wide Association Study and New Techniquesmentioning

confidence: 99%

HIV in Human Genomes and Therapeutics

Lu¹,

Lü²,

Yarla³

et al. 2017

HIV Curr Res

View full text Add to dashboard Cite

show abstract

“…The side effects (risks) predictions of different types of antidepressants in determine polymorphisms of ADME are relatively less dramatic and severe, such as fatigue and vomiting etc. [4][5][6][7]. Drug-toxic molecules and drug-targeted molecules are proposed to be different mechanisms of action in many ways.…”

Section: Past Achievements Of Suicide Therapymentioning

confidence: 99%

“…Human suicide is a common symptom of depression/mental illness worldwide [1][2][3][4][5][6][7]. Owing to long term economic depression in recent years, human suicide might still persist among most countries.…”

Section: Introductionmentioning

confidence: 99%

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Genetics in Suicide Treatments, Modern Diagnosis Establishments

Dy¹,

Tr²,

Jy³

et al. 2017

J Ment Disord Treat

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“…Currently, we may no longer call mathematics-or physics-majored student "layman" in biomedical studies. Previously, we speculated that mathematics-or physics-majored students can be the major-forces in genomic studies in both DNA drafting and post-genome analysis [1,2]. Similarly, in systems biology studies, theoretic physic-majored students or scholars are proposed to be one of the commonest participants in scientific investigations of modern biology [3].…”

Section: New Insightsmentioning

confidence: 99%