Genetic and Environmental Control of Antibiotic Production

Lc, Vining

doi:10.1016/b978-0-7506-9095-9.50007-1

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…are soil bacteria that produce many kinds of secondary metabolites, some of which suppress the growth of other bacteria or fungi. They have been isolated from various environments, including different soils, plant materials, waters, and marine sediment (Goodfellow and Williams 1983;Vining and Stuttard 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Most of them are produced by Streptomyces strains (Klug and Odelson 1992;Vining and Stuttard 1995). A biochemical alteration of the 50S subunit of the bacterial ribosome, namely N6-dimethylation of a single adenine residue at the position 2058 in 23S rRNA, confers resistance to all members belonging to the MLS group of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

“…A biochemical alteration of the 50S subunit of the bacterial ribosome, namely N6-dimethylation of a single adenine residue at the position 2058 in 23S rRNA, confers resistance to all members belonging to the MLS group of antibiotics. The result is a reduction of affinity between the antibiotic and the ribosome and the inability of the drug to inhibit the synthesis of proteins in resistant microorganism's (Vining andStuttard 1995 andCocito et al 1997).…”

Section: Introductionmentioning

confidence: 99%

“…In Staphylococci, inducible strains are resistant to 14-member and 16-membered macrolides, lincosamides, and streptogramin B antibiotics remain active in vitro. This is due to the fact that only 14 and 15 member's macrolides are Correspondence to: Ileana González Bonet,Centre for Pharmaceutical Chemistry,PO Box 6990,Cubanacán,Havana, © 1999 The Society for Applied Microbiology effective induces of methylase synthesis (Vining and Stuttard 1995;Baquero 1997;Endouk 1997;Werckenthin and Schwarz 1997).…”

Section: Introductionmentioning

confidence: 99%

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Ecological approach of macrolide-lincosamides-streptogramin producing Actinomyces from Cuban soils

González

Niebla

Lemus

et al. 1999

Lett Appl Microbiol

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We report in this study the frequency of Streptomyces strains to produce macrolide‐lincosamide‐streptogramin (MLS) antibiotics isolated from Cuban soils. The screening assay is based on the induction of MLS‐resistance phenotype in a clinical isolated strain of Staphylococcus aureus S‐18. Our results suggest that of 800 Streptomyces strains isolated from different soil samples, 6% were positives in the screening test used. The ferralitic red soil from Pinar del Río (north) provided the major percentage (3·6%) of MLS producing strains. The other soil samples tested belonging to Guira de Melena and Bauta in Havana, Matanzas City, Topes De Collantes (Villa Clara), and Soroa Mountains (Pinar del Rio) hill reached very low percentages.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ecological approach of macrolide-lincosamides-streptogramin producing Actinomyces from Cuban soils

González

Niebla

Lemus

et al. 1999

Lett Appl Microbiol

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“…strain GN101 (23). In parallel with antibiotic production in the domain Bacteria (33), halocins H4, S8, and HalR1 are all initially detected as the cultures leave exponential growth and enter stationary phase (21). Consequently, we chose halocins, beginning with halocin H4, as models to study stationary-phase gene expression in the haloarchaea.…”

mentioning

confidence: 99%

Isolation, sequence, and expression of the gene encoding halocin H4, a bacteriocin from the halophilic archaeon Haloferax mediterranei R4

et al. 1997

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The first gene to encode a haloarchaeal bacteriocin (halocin H4) has been cloned and sequenced from Haloferax mediterranei R4. Both the signal sequence in the halocin H4 preprotein and the monocistronic halH4 gene have some unusual features. The physiology of halH4 expression reveals that although halH4 transcripts are present at low basal levels during exponential growth, halocin H4 activity first appears as the culture enters stationary phase. As halocin activity levels increase, so do transcript levels, but then activity levels decrease precipitously while transcript levels remain elevated.Halocins are haloarchaeal equivalents of eubacterial bacteriocins (2) and were first discovered in 1982 by F. RodriguezValera (24). Although nearly universal in halobacterial rods (17, 32), only three halocins have been characterized in any detail: halocin H4 from Haloferax mediterranei R4 (15, 16), halocin H6 from Haloferax gibbonsii Ma2.39 (30, 31), and halocin HalR1 from Halobacterium sp. strain GN101 (23). In parallel with antibiotic production in the domain Bacteria (33), halocins H4, S8, and HalR1 are all initially detected as the cultures leave exponential growth and enter stationary phase (21). Consequently, we chose halocins, beginning with halocin H4, as models to study stationary-phase gene expression in the haloarchaea.Isolation of the halH4 gene. Halocin H4 was purified from H. mediterranei R4 (ATCC 33500) culture supernatants essentially as described elsewhere (4, 15). The amino-terminal sequences of the secreted protein and of two tryptic fragments (numbers 9 and 17 [ Fig. 1]) were used to design inosinecontaining degenerate oligodeoxynucleotide primers. Using these primers, we amplified the 5Ј end of the halocin H4 gene (halH4) by PCR and used the larger product (150 bp) as a probe to recover the gene from an enriched HindIII plasmid library.The start site of transcription of the halH4 gene was determined by primer extension (26). Note that the initiator AUG codon is only 4 bases from the 5Ј end of the message (Fig. 1). Similar leaderless transcripts are produced by other haloarchaeal genes, including bop (7); brp (3); hop (5); and arcA, arcB, and arcC (25). Inspection of the DNA sequence upstream of the halH4 transcriptional start site reveals a box A haloarchaeal promoter hexamer (Fig.

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Increase in the production of allelopathic substances by Prymnesium parvum cells grown under N- or P-deficient conditions

Granéli¹,

Johansson²

2003

Harmful Algae

185

136

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Genetic and Environmental Control of Antibiotic Production

Cited by 5 publications

References 15 publications

Ecological approach of macrolide-lincosamides-streptogramin producing Actinomyces from Cuban soils

Ecological approach of macrolide-lincosamides-streptogramin producing Actinomyces from Cuban soils

Isolation, sequence, and expression of the gene encoding halocin H4, a bacteriocin from the halophilic archaeon Haloferax mediterranei R4

Increase in the production of allelopathic substances by Prymnesium parvum cells grown under N- or P-deficient conditions

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