Genetic and environmental determinants of the PON‐1 phenotype

Abstract

PON-1 Q192R, C-107T and L55M genotype, alcohol consumption, smoking and HDL levels are determinants of serum PON-1 phenotype. The contributions of the genetic markers to the PON-1 phenotype are stronger than the contributions of the lifestyle determinants.

Original article Paraoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia

“…PON1 activity was the highest in CC and the lowest in TT genotype (CC>CT>TT) of promoter -108C>T polymorphism. The same results were obtained by other authors in population-based studies [3,28]. It was suggested that -108 polymorphism is localized within a probable binding site for Sp1, a ubiquitous transcription factor common in TATA-less genes such as PON1 [3].…”

Distribution of Paraoxonase 1 polymorphisms and activities in obese patients

“…Adipokine imbalance leads to an increase of inflammatory mediators, which, in turn, will trigger the proatherogenic and proinflammatory activities of the HDL-PON1 complex (24). Similar to other cross-sectional studies (25), multiple regression analysis showed that the Q192R polymorphism is the major determinant of P-ase, while L55M polymorphism influenced all three activities.…”

Discordance in Human Paraoxonase-1 Gene between Phenotypes and Genotypes in Chronic Kidney Disease

“…They found that PON1–192, PON1-107 and PON1–55 genotype, alcohol consumption, smoking and HDL levels are determinants of serum PON1 phenotype. They concluded that the contributions of the genetic markers to the PON1 phenotype are stronger than the contributions of the lifestyle determinants [27]. In this study the reference population did not consist of exclusively healthy individuals.…”

“…Phenotype is also influenced by environmental factors. Recently, Roest et al [27] investigated the determinants of PON1 bioavailability and activity in postmenopausal women. They found that PON1–192, PON1-107 and PON1–55 genotype, alcohol consumption, smoking and HDL levels are determinants of serum PON1 phenotype.…”