“…MIR127, MIR9, MIR148, MIR203, MIR340, MIR18, and MIR34b/c are several examples of DNA methylation regulated miRNAs. 14,23,[31][32][33] In the case of MIR34b/c, this locus has been reported to be epigenetically regulated in several cancers 31,34 Recently, MIR34b/c was shown to be a tumor suppressor mediating p53 activation in both colon and gastric cancers. 23,33,35 In addition, methylation of MIR124 families was initially described in colorectal cancer and was subsequently reported in tumors or other origins.…”