Genetic and Functional Analysis of the Ia Antigens: Their Possible Role in Regulating the Immune Response

Mcdevtit, Hugh O.; Delovitch, Terry L.; Press, Joan L.; Murphy, Donal B.

doi:10.1111/j.1600-065x.1976.tb00221.x

Cited by 42 publications

(44 citation statements)

References 54 publications

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“…Ia antigens have been identified as components of antigen-specific helper factors (8), antigen-specific suppressor factors (9), and antigen-nonspecific "allogeneic effect" factors (10). They are also involved in the mediation of immunoglobulin (Ig)M/ IgG switch in the course of the humoral immune response (11).…”

Section: Introductionmentioning

confidence: 99%

A Study of Human Leukocyte D Locus Related Antigens in Graves' Disease

Farid¹,

Sampson²,

Noel³

et al. 1979

J. Clin. Invest.

103

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Section: Introductionmentioning

confidence: 99%

A Study of Human Leukocyte D Locus Related Antigens in Graves' Disease

Farid¹,

Sampson²,

Noel³

et al. 1979

J. Clin. Invest.

103

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“…Indeed, soluble molecules expressing Ia alloantigenic determinants are involved in a number of cell interaction phenomena that specifically enhance or suppress the immune response (9)(10)(11)(12). In addition, subpopulations of lymphocytes performing different functions (e.g., memory B cells, suppressor T cells) preferentially express different Ia alloantigens (13)(14)(15), suggesting that such molecules are involved in mediating these functions.…”

mentioning

confidence: 99%

Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.

Silver¹,

Russell²,

Reis³

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

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Alloantisera directed against the alloantigens determined b the I-E and IC subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or IC subregion is homologous to the large chain of the human HILA-D region alloantigen, although the small chains isolated from these two species do not display any such homology. The

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“…Alloantisera prepared in this manner by Shreffler and David (46), Klein and Hauptfeld (47) and McDevitt and associates (48) in mice and Schwartz, Paul and Shcvach (49) in guinea pigs reacted with alloantigens termed Ia (immune response-associated) antigens expressed on B lymphocytes and a significant fraction of macrophages (50). A detailed study by Shreffler and David (46) of the specificities detected by anti-Ia antisera revealed the considerable polymorphism of these molecules.…”

Section: Ia Molecules and Histocompatibility Antigensmentioning

confidence: 99%

The Role of MHC Gene Products in Immune Regulation and its Relevance to Alloreactivity

Benacerraf¹

1992

Scand J Immunol

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The immune system has evolved the capacity to react specifically with a very large number of foreign molecules with which it had no previous contact, while avoiding reactivity for autologous molecules, naturallyantigenic in other species or in other individuals of the same species.Immunological research has been directed to the elucidation of this phenomenon ever since Ehrlich (1) proposed that immunocompetent cells bear receptors for antigen identical with the antibodies to be produced. Gowans (2) identified lymphocytes as the cells responsible for immune phenomena. Burnet (3) proposed the clonal selection theory of immunity which postulated that: 1) lymphocytes differentiate as clones bearing antibody receptors of unique specificity, 2) antibody responses reflect the selective expansion of specific lymphocytes, following the binding of antigen, and their differentiation as secretors of antibody, identical in specificity with the antigen binding receptors on the original clones. The Burnet hypothesis was verified experimentally (4,5,6) and was accepted as a major advance, concerned primarily with the response of antibody producing cells, later identified as B lymphocytes (7) and plasma cells. Accordingly, studies on the specificity of antibodies and on the structure of immunoglobulins revealed that these molecules (8,9) and their structural genes (10,ll) evolved in a way that ensures the enormous diversity of antibody combining sites observed.The discovery by Miller (12) and by Good (13) that lymphocytes differentiate into two separate classes of cells (T and B) with distinct functions, the identification of cellular immune phenomena mediated by T cells (14) and the demonstration that immune responses are regulated by helper (15,16,17) and suppressor (18,19) cells and by macrophages (20) emphasized the complexity of the immune system and the critical role played by T lymphocytes in the regulation of immunity.It became increasingly apparent that the clonal selection theory, although correct, did not take into account the complex cellular and molecular interactions essential to immune phenomena or the restrictions these interactions dictate in the specificity of T cells. An additional system, beside specific immunoglobulins, involving the products of the major histocompatibility complex (MHC) was shown to be critically involved in the manner by which T cells 597

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Genetic and Functional Analysis of the Ia Antigens: Their Possible Role in Regulating the Immune Response

Cited by 42 publications

References 54 publications

A Study of Human Leukocyte D Locus Related Antigens in Graves' Disease

A Study of Human Leukocyte D Locus Related Antigens in Graves' Disease

Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.

The Role of MHC Gene Products in Immune Regulation and its Relevance to Alloreactivity

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