Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: A Dutch case-control study

Verkleij-Hagoort, Anna C.; Driel, Lydi M.J.W. van; Lindemans, Jan; Isaacs, Aaron; Steegers, Eric A.P.; Helbing, Willem A.; Uitterlinden, André G.; Steegers‐Theunissen, R.P.M.

doi:10.1016/j.ymgme.2007.12.002

Cited by 36 publications

(38 citation statements)

References 38 publications

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“…In addition, the 66AG/524CT combined genotype was associated with a 1.6-fold higher risk of VSD, while the 66GG/524CT combined genotype was associated with a 2.5-fold increased risk of PDA, compared with controls. Although some previous researchers reported that the two polymorphisms (A66G and C524T) of the MTRR gene are not associated with an increased risk of CHDs (van Beynum et al, 2006;Fredriksen et al, 2007;Verkleij-Hagoort et al, 2008;Shaw et al, 2009), we found a modest association between the A66G and C524T alleles of the MTRR gene and CHDs in the Chinese Han population. These differences between reports might be due to ethnic heterogeneity.…”

Section: Discussioncontrasting

confidence: 99%

A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population

Zeng¹,

Liu²,

Tong³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Congenital heart defects (CHDs) are the most common birth defects; genes involved in homocysteine/folate metabolism may play important roles in CHDs. Methionine synthase reductase (MTRR) is one of the key regulatory enzymes involved in the metabolic pathway of homocysteine. We investigated whether two polymorphisms (A66G and C524T) of the MTRR gene are associated with CHDs. A total of 599 children with CHDs and 672 healthy children were included; the polymorphisms were detected by PCR and RFLP analysis. Significant differences in the distributions of A66G and C524T alleles were observed between CHD cases and controls, and slightly increased risks of CHD were associated with 66GG and 524CT genotypes (odds ratios = 1.545 and 1.419, respectively). The genotype frequencies of 524CT in the VSD subgroup, 66GG and 524CT in the PDA subgroup were significantly different from those of controls. In addition, the combined 66AA/524CT, 66AG/524CT and 66GG/524CT in CHDs had odds ratios = 1.589, 1.422 and 1.934, respectively. Increased risks were also observed in 66AA/524CT and 66GG/524CT for ASD, 66AG/524CT for VSD, as well as 66GG/524CT for PDA. In conclusion, MTRR A66G and C524T polymorphisms are associated with increased risk of CHDs.

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Section: Discussioncontrasting

confidence: 99%

A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population

Zeng¹,

Liu²,

Tong³

et al. 2011

Genet. Mol. Res.

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“…Several case-control studies in Netherlands have noted that AdoMet, S-adenosyl-L-homocysteine, and tHcy concentrations were significantly higher in women who had neonates with congenital heart defects (CHDs) than newborns without CHDs (109)(110)(111)(112). One case-control study in Netherlands also found that women with low serum vitamin B-12 concentrations (#185 pmol/L) had a 4 times greater odds of having a neonate with nonsyndromic orofacial cleft (OR: 4.4; 95% CI: 1.1, 18.2; P < 0.05) than women with replete vitamin B-12 status (113).…”

Section: Literature Reviewmentioning

confidence: 99%

Vitamin B-12 and Perinatal Health

Finkelstein

Layden

Stover

2015

Advances in Nutrition

139

104

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Vitamin B-12 deficiency (<148 pmol/L) is associated with adverse maternal and neonatal outcomes, including developmental anomalies, spontaneous abortions, preeclampsia, and low birth weight (<2500 g). The importance of adequate vitamin B-12 status periconceptionally and during pregnancy cannot be overemphasized, given its fundamental role in neural myelination, brain development, and growth. Infants born to vitamin B-12-deficient women may be at increased risk of neural tube closure defects, and maternal vitamin B-12 insufficiency (<200 pmol/L) can impair infant growth, psychomotor function, and brain development, which may be irreversible. However, the underlying causal mechanisms are unknown. This review was conducted to examine the evidence that links maternal vitamin B-12 status and perinatal outcomes. Despite the high prevalence of vitamin B-12 deficiency and associated risk of pregnancy complications, few prospective studies and, to our knowledge, only 1 randomized trial have examined the effects of vitamin B-12 supplementation during pregnancy. The role of vitamin B-12 in the etiology of adverse perinatal outcomes needs to be elucidated to inform public health interventions. Adv Nutr 2015;6:552-63.

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“…Low maternal B12 status has been associated with preterm birth [1], intra-uterine growth restriction [2], congenital heart defects [3], neural tube defects (NTDs) [4], and impaired cardiometabolic health in the offspring [5,6]. Maternal B12 status is a key determinant of infant B12 status [7,8].…”

Section: Introductionmentioning

confidence: 99%

South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women

et al. 2017

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Vitamin B12 (B12) adequacy during pregnancy is crucial for maternal health and optimal fetal development; however, suboptimal B12 status has been reported in pregnant Canadian women. Methylmalonic acid (MMA) is a sensitive indicator of B12 status. Since few studies have measured MMA during pregnancy in Canadian women, the objective of this study was to evaluate B12 status in pregnant women living in Metro Vancouver, using both plasma total B12 and MMA. We recruited a convenience sample of 320 pregnant women between 20 and 35 gestational weeks from local healthcare facilities. Plasma total B12 concentrations indicative of deficiency (<148 pmol/L) and suboptimal B12 status (148–220 pmol/L) were found in 18% and 33% of the women, respectively. Normal plasma MMA concentration (<210 nmol/L) was observed in 82% of all women. Gestational age was a strong predictor of plasma total B12 and MMA concentration, and South Asian ethnicity of B-12 deficiency and MMA concentrations. Overall, there was a high discrepancy between the prevalence of B12 inadequacy depending on the biomarker used. Independently, however, South Asian women were at particular risk for B12 deficiency, likely due to lower animal source food intake. Further study of this vulnerable group and performance testing of B12 biomarkers is warranted.

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Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: A Dutch case-control study

Cited by 36 publications

References 38 publications

A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population

A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population

Vitamin B-12 and Perinatal Health

South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women

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