Genetic and Molecular Biology of Multiple Sclerosis Among Iranian Patients: An Overview

Moghbeli, Meysam

doi:10.1007/s10571-019-00731-2

Cited by 4 publications

(3 citation statements)

References 251 publications

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“…Depending on whether the brain, brain stem, cerebellum, spinal cord of MS patients are affected simultaneously or successively (5), the clinical features and symptoms vary, mainly for limb weakness, paresthesia, decreased vision, ataxia, etc. (6).…”

Section: Introductionmentioning

confidence: 99%

Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

Dou

Zhou

et al. 2021

Front. Immunol.

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The etiology of multiple sclerosis (MS) is not clear, and the treatment of MS presents a great challenge. This study aimed to investigate the pathogenesis and potential therapeutic targets of MS and to define target genes of matrine, a quinolizidine alkaloid component derived from the root of Sophorae flavescens that effectively suppressed experimental autoimmune encephalomyelitis (EAE), an animal model of MS. To this end, the GSE108000 gene data set in the Gene Expression Omnibus Database, which included 7 chronic active MS lesions and 10 control samples of white matter, was analyzed for differentially expressed genes (DEGs). X cell was used to analyze the microenvironmental differences in brain tissue samples of MS patients, including 64 types of immune cells and stromal cells. The biological functions and enriched signaling pathways of DEGs were analyzed by multiple approaches, including GO, KEGG, GSEA, and GSVA. The results by X cell showed significantly increased numbers of immune cell populations in the MS lesions, with decreased erythrocytes, megakaryocytes, adipocytes, keratinocytes, endothelial cells, Th1 cells and Tregs. In GSE108000, there were 637 DEGs, including 428 up-regulated and 209 down-regulated genes. Potential target genes of matrine were then predicted by the network pharmacology method of Traditional Chinese medicine, and 12 key genes were obtained by cross analysis of the target genes of matrine and DEGs in MS lesions. Finally, we confirmed by RT-PCR the predicted expression of these genes in brain tissues of matrine-treated EAE mice. Among these genes, 2 were significantly downregulated and 6 upregulated by matrine treatment, and the significance of this gene regulation was further investigated. In conclusion, our study defined several possible matrine target genes, which can be further elucidated as mechanism(s) of matrine action, and novel targets in the treatment of MS.

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Section: Introductionmentioning

confidence: 99%

Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

Dou

Zhou

et al. 2021

Front. Immunol.

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“…Author details 1 Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.…”

Section: Fundingmentioning

confidence: 99%

“…Autoimmune disorders are associated with immune system attack to the body's own organs, tissues, and cells [1,2]. They have an increasing frequency in industrialized countries.…”

Section: Introductionmentioning

confidence: 99%

Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview

Gachpazan

Akhlaghipour

Rahimi

et al. 2021

Autoimmun Highlights

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Background Systemic lupus erythematosus (SLE) is a clinicopathologically heterogeneous chronic autoimmune disorder affecting different organs and tissues. It has been reported that there is an increasing rate of SLE incidence among Iranian population. Moreover, the Iranian SLE patients have more severe clinical manifestations compared with other countries. Therefore, it is required to introduce novel methods for the early detection of SLE in this population. Various environmental and genetic factors are involved in SLE progression. Main body In present review we have summarized all of the reported genes which have been associated with clinicopathological features of SLE among Iranian patients. Conclusions Apart from the reported cytokines and chemokines, it was interestingly observed that the apoptosis related genes and non-coding RNAs were the most reported genetic abnormalities associated with SLE progression among Iranians. This review clarifies the genetics and molecular biology of SLE progression among Iranian cases. Moreover, this review paves the way of introducing an efficient panel of genetic markers for the early detection and better management of SLE in this population.

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Genetics of multiple sclerosis: lessons from polygenicity

Vandebergh

McCauley

Saarela

et al. 2022

The Lancet Neurology

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Genetic and Molecular Biology of Multiple Sclerosis Among Iranian Patients: An Overview

Cited by 4 publications

References 251 publications

Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview

Genetics of multiple sclerosis: lessons from polygenicity

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