Genetic and oxidative damage of peripheral blood lymphocytes in workers with occupational exposure to coal

The Cytokinesis-Block Micronucleus Assay on Peripheral Blood Lymphocytes as a Prospective Biological Test-System to Estimate the Influence of Radon on the Human Organism: Recent Progress and Future Prospects

“…Significant differences were observed between the exposed and unexposed groups based on the MN and NPB frequencies (7.46 ± 4.64 vs. 3.12 ± 2.93 and 12.33 ± 7.48 vs. 5.59 ± 4.06) (p < 0.001, Mann-Whitney U-test). No correlation was found between age and exposure [19].…”

“…Coal miners are constantly exposed to potentially hazardous environmental compounds. Therefore, characterising and estimating the risks of exposure is central to the safety of individuals working in a coal-mining environment [19].…”

Assessment of the genotoxicity and cytotoxicity in environmentally exposed human populations to heavy metals using the cytokinesis‐block micronucleus cytome assay

“…Our results are in strong correlation with the results suggesting that the frequencies of NPBs and NBUDs were significantly higher in the Pb‐exposed group as compared to the values measured in the control groups (Minozzo et al, ). Similarly, Rohr et al () demonstrated that the groups exposed to coal had significantly increased frequency of NPBs compared with unexposed individuals. Based on the obtained results, we can assume that frequencies of NPBs and NBUDs might be a more sensitive markers for measuring genotoxicity.…”

“…The increase of MN with age is likely due to a combination of various factors, which include the cumulative effect of acquired mutations in genes involved in DNA repair, chromosome segregation, as well as alterations in chromosomes caused by exposure to endogenous genotoxins, exposure to environmental or occupational genotoxic agents, and a range of unhealthy lifestyle factors (Milosevic‐Djordjevic et al, ; Fenech and Bonassi, ; Donmez‐Altuntas and Bitgen, ). On the other hand, there are several reports in which was reported that age had no effect on MNed cell rate (Di Giorgio et al, ; Neri et al, ; Rohr et al, ). Duffaud et al () demonstrated that age apparently had no significant effect on MNed cell rate in the group of healthy subjects.…”

“…Environmental metal pollution is not an unusual situation that can be seen in mining centers and the surrounding environments (Taylor et al, ). Coal mine dust is constituted primarily of hydrocarbons and metals such as Cd, Fe, Cu, Ni, Sb, Zn, and Pb (Donbak et al, ; Rohr et al, ). The combustion of coal accounts for 60% of the total primary energy supply in Bosnia (Dellantonio et al, ).…”