The Cytokinesis-Block Micronucleus Assay on Peripheral Blood Lymphocytes as a Prospective Biological Test-System to  Estimate the Influence of Radon on the  Human Organism: Recent Progress and  Future Prospects

Sinitsky, M. Yu.

doi:10.4236/ojgen.2014.41001

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…It has been previously shown that the CBMN assay is applicable to the assessment of some negative effects from radon and its decay products by different contingents (Sinitsky 2014).…”

Section: Introductionmentioning

confidence: 99%

Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (²²²Rn) concentration

Sinitsky

Ларионов

Asanov

et al. 2015

International Journal of Radiation Biology

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As a result of this study, the elevated frequency of cytogenetic damage in people with particular DNA-repair gene polymorphisms in response to chronic exposure to radon was demonstrated. It was shown that the genes and corresponding polymorphisms (the XpG gene Asp1104His polymorphism, the ADPRT gene Val762Ala polymorphism and the NBS1 gene Glu185Gln polymorphism) can be used as molecular genetic markers of increased individual radiosensitivity in long-term residents of areas with high concentrations of radon.

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“…It has been previously shown that the CBMN assay is applicable to the assessment of some negative effects from radon and its decay products by different contingents (Sinitsky 2014).…”

Section: Introductionmentioning

confidence: 99%

Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (²²²Rn) concentration

Sinitsky

Ларионов

Asanov

et al. 2015

International Journal of Radiation Biology

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“…Uranium (U) contamination in groundwater is of serious environmental concern. Prolonged consumption of elevated levels of U is undesirable for public health, as it could potentially affect the functioning of kidneys, liver, lungs, and bones and may cause cancer. − Presently, India does not have a drinking water limit (DWL) for U in its water quality standards. However, in view of the prevalence of U contamination in various parts of the country, an attempt is being made to incorporate the World Health Organization (WHO) prescribed limit of 30 μg L –1…”

Section: Introductionmentioning

confidence: 99%

Investigation of Potential Drivers of Elevated Uranium Prevalence in Indian Groundwaters with a Unified Speciation Model

Sujathan

Singh

2023

Environ. Sci. Technol.

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Elevated uranium (U) (>WHO limit of 30 μg L −1 ) in Indian groundwaters is primarily considered geogenic, but the specific mineralogical sources and mechanisms for U mobilization are poorly understood. In this contribution, statistical and geochemical analyses of well-constrained metadata of Indian groundwater quality (n = 342 of 8543) were performed to identify key parameters and processes that influence U concentrations. For geochemical predictions, a unified speciation model was developed from a carefully compiled and updated thermodynamic database of inorganic, organic (Stockholm Humic model), and surface complexation reactions and associated constants. Critical U contamination was found at shallow depths (<100 m) within the Indo-Gangetic plain, as determined by bivariate nonparametric Kendall's Tau b and probability-based association tests. Analysis of aquifer redox states, multivariate hierarchical clusters, and principal components indicated that U contamination was predominant not just in oxic but mixed (oxic−anoxic) aquifers under high Fe, Mn, and SO 4 concentrations, presumably due to U release from dissolution of Fe/Mn oxides or Fe sulfides and silicate weathering. Most groundwaters were undersaturated with respect to relevant U-bearing solids despite being supersaturated with respect to atmospheric CO 2 (average pCO 2 of reported dissolved inorganic carbonate (DIC) data = 10 −1.57 atm). Yet, dissolved U did not appear to be mass limited, as predicted solubilities from reported sediment concentrations of U were ∼3 orders of magnitude higher. Integration of surface complexation models of U on typical aquifer adsorbents, ferrihydrite, goethite, and manganese dioxide, was necessary to explain dissolved U concentrations. Uranium contamination probabilities with increasing dissolved Ca and Mn exhibited minima at equilibrium solubilities of calcite [∼50 mg L −1 ] and rhodochrosite [∼0.14 mg L −1 ], respectively, at an average groundwater pH of ∼7.5. A potential indirect control of such U-free carbonate solids on U mobilization was suggested. For locations (n = 37) where dissolved organic carbon was also reported, organic complexes of U contributed negligibly to dominant U speciation at the groundwater pH. Overall, the unified model suggested competitive dissolution−precipitation and adsorption−desorption controls on U speciation. The model provides a quantitative framework that can be extended to understand dominant mobilization mechanisms of geogenic U in aquifers worldwide after suitable modifications to the relevant aquifer parameters.

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“…In ad di tion, it is reported that ra don gas in dwell ings causes about 21,100 lung can cer deaths per years in the USA [4]. Ra don decays into two prod ucts, 218 Po and 214 Po, and their inter ac tion with the bi o log i cal tis sues in the lungs leads to DNA dam age [5] which causes cell mu ta tion that leads to can cer [6]. Ra don co mes from soil, build ing ma te ri als, and wa ter sup plies.…”

Section: Introductionmentioning

confidence: 99%

Measurement of indoor radon concentrations in different dwellings in Arar, Saudi Arabia

Abdalla

El‐Gamal

2018

NUCL TECH RAD PROT

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In door ra don con cen tra tions in 33 dwell ings in Arar city were mea sured us ing a CR-39 detec tor. This work is the first in the re gion and was done to as sess the health risks. The ex po sure time was about 4 months, from May to Sep tem ber 2017. It was found that the in door ra don con cen tra tion changed in the range from 7.7 to 89.1 Bqm-3 with an over all av er age of 44.05 ± 6.21 Bqm-3 while the geo met ric mean is 39.51 Bqm-3 with a geo met ric stan dard de vi a tion of 1.67. These val ues are within the ac cept able level set by the In ter na tional Com mit tee for Radi a tion Pro tec tion. The an nual ef fec tive dose re ceived by the pop u la tion of Arar was re ported and it var ied in the range 0.16-1.82 mSv with an av er age value of 0.9 ±.0.16 mSv and the geomet ric mean is 0.81 mSv. The ex po sure to ra don prog eny was stud ied where the min i mum, max i mum, av er age, and geo met ric mean of ex po sure are 0.83×10-3 , 9.63×10-3 , 4.76 ± 0.67× 10-3 and 5.05×10-3 WLM, re spec tively. Fi nally, for the es ti ma tion of can cer risks, the ex cess life time can cer risk was in ves ti gated. Its av er age value was 3.7×10-3 which is rel a tively higher.

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The Cytokinesis-Block Micronucleus Assay on Peripheral Blood Lymphocytes as a Prospective Biological Test-System to Estimate the Influence of Radon on the Human Organism: Recent Progress and Future Prospects

Cited by 8 publications

References 27 publications

Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (²²²Rn) concentration

Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (²²²Rn) concentration

Investigation of Potential Drivers of Elevated Uranium Prevalence in Indian Groundwaters with a Unified Speciation Model

Measurement of indoor radon concentrations in different dwellings in Arar, Saudi Arabia

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The Cytokinesis-Block Micronucleus Assay on Peripheral Blood Lymphocytes as a Prospective Biological Test-System to Estimate the Influence of Radon on the Human Organism: Recent Progress and Future Prospects

Cited by 8 publications

References 27 publications

Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (222Rn) concentration

Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (222Rn) concentration

Investigation of Potential Drivers of Elevated Uranium Prevalence in Indian Groundwaters with a Unified Speciation Model

Measurement of indoor radon concentrations in different dwellings in Arar, Saudi Arabia

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Product

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Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (²²²Rn) concentration

Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (²²²Rn) concentration