2001
DOI: 10.1016/s0009-2797(01)00171-5
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Genetic and reproductive toxicity of butadiene and isoprene

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Cited by 31 publications
(14 citation statements)
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“…This test is already beginning to appear in gamete biology (84). In fact, measurements of sperm DNA modifications, such as 8-hydroxy-2deoxyguanosine (85) and xenobiotic adduct formation (86), have been gaining momentum (45,87,88).…”
Section: Choosing the Assaymentioning
confidence: 99%
“…This test is already beginning to appear in gamete biology (84). In fact, measurements of sperm DNA modifications, such as 8-hydroxy-2deoxyguanosine (85) and xenobiotic adduct formation (86), have been gaining momentum (45,87,88).…”
Section: Choosing the Assaymentioning
confidence: 99%
“…33 Clastogenic data of BD's epoxy metabolites, especially that of DEB, were also available in germinal cells in both mice and rats from spermatid micronucleus tests and heritable translocation assays. 34,35 These results indicated that male reproductive genotoxicity of BD may still depend on the production of potent metabolites. 10,11 Our studies showed that DEB-induced long tails in the comet assay and the increase of MN frequencies in the CBMN assay, and the upregulation of γ-H2AX expression in Western blot in GC-2 cells further confirmed such damage.…”
Section: ■ Discussionmentioning
confidence: 90%
“…BDO 2 exposure increases cellular toxicity and alters apoptosis in prostate cells by increasing caspase activation without change in down stream targets such as PARP. Class I carcinogens such as BDO 2 have been shown to induce apoptosis via death receptor pathways leading to inhibition of apoptosis. Thus, our work introduces the possibility that micro-doses of carcinogens such as BDO 2 may promote prostate tumors by modulation specific cellular activity.…”
Section: Discussionmentioning
confidence: 99%
“…The reactive intermediates 1,2-epoxy-3-butene, 1,3,4-diepoxybutane, and 3,4-epoxy-1, 2-butanediol all play significant roles in the toxicity of 1,3-butadiene. These metabolites are capable of reacting with macromolecules such as DNA to induce a variety of genotoxic effects in mice and rats as well as in human cells in vitro [1][2][3][4][5][6]. The metabolism and genetic toxicity of 1,3-butadiene and its oxidative metabolites in humans and rodents is well established.…”
Section: Introductionmentioning
confidence: 99%