Genetic and sex influence on neuropathic pain‐like behaviour after spinal cord injury in the rat

Dominguez, Cecilia A.; Ström, Mikael; Gao, Tianle; Zhang, L.; Olsson, Tomas; Wiesenfeld‐Hallin, Zsuzsanna; Xu, Xiao‐Jun; Piehl, Fredrik

doi:10.1002/j.1532-2149.2012.00144.x

Cited by 27 publications

(18 citation statements)

References 48 publications

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“…What little work has been done in animal models to compare a sexdependency of pain development after SCI has also demonstrated controversial results. Female rats have been reported to both increase (29) and decrease (30) the prevalence of developing mechanical and thermal allodynia after SCI, while no sexdependent effects have been found in mice (31,32). Importantly, several studies investigating analgesic strategies to reduce pain caused by peripheral nerve injury have converging evidence that many pain-relieving agents exert sexually dichotomous effects (33)(34)(35)(36)(37)(38).…”

Section: Clinical Observations Support That Females Recover Better Fomentioning

confidence: 99%

Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury

et al. 2020

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In response to NIH initiatives to investigate sex as a biological variable in preclinical animal studies, researchers have increased their focus on male and female differences in neurotrauma. Inclusion of both sexes when modeling neurotrauma is leading to the identification of novel areas for therapeutic and scientific exploitation. Here, we review the organizational and activational effects of sex hormones on recovery from injury and how these changes impact the long-term health of spinal cord injury (SCI) patients. When determining how sex affects SCI it remains imperative to expand outcomes beyond locomotor recovery and consider other complications plaguing the quality of life of patients with SCI. Interestingly, the SCI field predominately utilizes female rodents for basic science research which contrasts most other male-biased research fields. We discuss the unique caveats this creates to the translatability of preclinical research in the SCI field. We also review current clinical and preclinical data examining sex as biological variable in SCI. Further, we report how technical considerations such as housing, size, care management, and age, confound the interpretation of sex-specific effects in animal studies of SCI. We have uncovered novel findings regarding how age differentially affects mortality and injury-induced anemia in males and females after SCI, and further identified estrus cycle dysfunction in mice after injury. Emerging concepts underlying sexually dimorphic responses to therapy are also discussed. Through a combination of literature review and primary research observations we present a practical guide for considering and incorporating sex as biological variable in preclinical neurotrauma studies.

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Section: Clinical Observations Support That Females Recover Better Fomentioning

confidence: 99%

Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury

et al. 2020

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“…In addition, some studies suggest that certain patients may be genetically more susceptible to neurosensory changes after nerve injury. 52,53 It is also important to realize that published studies of neurosensory deficits have not always separated painful conditions from nonpainful alterations. Although all neurosensory deficits have a negative impact on the patient, persistent neuropathic pain disorders are likely to have the greatest effect on quality of life.…”

Section: Discussionmentioning

confidence: 99%

Persistent Pain and Neurosensory Disturbance After Dental Implant Surgery

Al‐Sabbagh

Okeson

Khalaf

et al. 2015

Dental Clinics of North America

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“…Alternatively, pain development may have genetic susceptibility (Dominguez et al . , , Binkley et al . ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence, predictive factors and clinical course of persistent pain associated with teeth displaying periapical healing following nonsurgical root canal treatment: a prospective study

et al. 2018

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Aims To investigate the prevalence, pain catastrophizing and other predictive factors and clinical course of persistent pain/discomfort associated with teeth displaying periapical healing following nonsurgical root canal treatment (NSRCT). Methodology One hundred and ninety‐eight patients (264 teeth) who had NSRCT were reviewed at 5–14 months, postoperatively. Teeth with persistent post‐treatment pain or discomfort, plus evidence of periapical healing were further monitored 0.5, 4 and 10 years later. Pain Catastrophizing Scale (PCS) and Short Form of the McGill Pain Questionnaire (SF‐MPQ) were completed. Predictive factors were investigated using logistic regression models. Results Twenty‐four per cent (60/249) of teeth displaying periapical healing at first review were associated with persistent pain or discomfort. Fifty‐five teeth monitored 6–7 months later were associated with reduction in pain (17/30) or discomfort (7/25). Cone beam computed tomography (CBCT) of eight teeth with persistent symptoms and complete periapical healing (by conventional radiographs) revealed distinct, small apical radiolucencies (n = 3) or root apex fenestration through the buccal plate (n = 2). History of chronic pain (headache, temporo‐mandibular joint, masticatory muscle, neck, shoulder or back pain; P = 0.005), preoperative pain (P = 0.04), responsive pulp (P = 0.009), tooth crack (P = 0.05) and small periapical radiolucency (P = 0.005) were significant predictive factors. The PCS revealed 16 patients (22 teeth) were catastrophizers (PCS ≥ 30), but this had no influence on post‐treatment symptoms (P = 0.5). Conclusions Persistent pain or discomfort associated with teeth showing periapical healing at the first review after NSRCT, decreased in intensity in most cases over the following 6 months. Longer‐term follow‐up revealed spontaneous improvement or symptom resolution in the majority of those with confirmed radiographic the absence of periapical disease. Five predictive factors (history of chronic pain, teeth with responsive pulps, association with pain, diagnosis of tooth crack before treatment and diameter of preoperative radiolucency) were identified.

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Genetic and sex influence on neuropathic pain‐like behaviour after spinal cord injury in the rat

Cited by 27 publications

References 48 publications

Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury

Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury

Persistent Pain and Neurosensory Disturbance After Dental Implant Surgery

Prevalence, predictive factors and clinical course of persistent pain associated with teeth displaying periapical healing following nonsurgical root canal treatment: a prospective study

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