Genetic Aspects of Idiopathic Scoliosis

Hr, Cowell; Jn, Hall; Gd, MacEwen

doi:10.1097/00003086-197207000-00018

Cited by 155 publications

(40 citation statements)

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“…Studies aimed at determining how the disorder is handed down to generations have reported that idiopathic scoliosis is not inherited in an autosomal dominant or X-linked dominant manner except for a couple of familial forms (10,20,28,30,83,85,105). It was discovered that idiopathic scoliosis has multi-factorial hereditary characteristic and multiple genes are affected for the development of the disease.…”

Section: Genetic-hormonal Causesmentioning

confidence: 99%

Idiopathic scoliosis

Yaman¹,

Dalbayrak²

2013

Turkish Neurosurgery

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Scoliosis refers to curves exceeding 10 degrees observed through posterioanterior direct radiography. In fact, the diagnosis for idiopathic scoliosis is accepted to exclude already available causes. The aim of this paper was to review the etiopathogenesis, classification systems and the treatment management of idiopathic scoliosis. A search in the National Library of Medicine (Pubmed) database using the key words 'idiopathic' and 'scoliosis' was performed. For the literature review, papers concerning the etiopathogenesis, classification and treatment were selected among these articles. A search in the National Library of Medicine (Pubmed) database using the key words 'idiopathic' and 'scoliosis' yielded 4518 articles published between 1947 and 2013. The main hypothesis put forward included genetic factors, hormonal factors, bone and connective tissue anomalies. King, Lenke, Coonrad and Peking Union Medical College (PUMC) classifications were the main classification systems for idiopathic scoliosis. Exercise, bracing and anterior, posterior or combined surgery when indicated are the choices for the treatment. Every idiopathic scoliosis case has to be managed to its own characteristics. It is the post-operative appearance that the surgeons are perhaps the least interested but the adolescent patients the most interested in. The aim of scoliosis surgery is to restore the spine without neurological deficit.

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Section: Genetic-hormonal Causesmentioning

confidence: 99%

Idiopathic scoliosis

Yaman¹,

Dalbayrak²

2013

Turkish Neurosurgery

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“…Plusieurs perspectives divergentes ont été présentées dans l'espoir de définir plus clairement l'étiologie de la SIA et d'expliquer les différentes perturbations associées à la déformation du rachis observée chez les patients SIA [1,2]. Dans cette synthèse nous proposons un survol des différents facteurs considérés dans l'étiologie de la SIA et nous nous attarderons sur les plus récents concepts moléculaires impliquant un défaut de signalisation de la mélatonine dans l'étiopa-thogénie de la SIA.…”

Section: Facteurs éTiologiques De La Scoliose Idiopathiqueunclassified

“…Bien que la composante héréditaire puisse être présente dans certaines familles, on note que 85 % des scolioses idiopathiques constituent des cas sporadiques : elles surviennent dans des familles n'ayant aucun antécédent. Néanmoins, plusieurs études ont clairement mis en évidence que la SIA survient avec une fréquence plus élevée dans certaines familles [1]. Les travaux de Wynne-Davies [5] et de DeGeorge [6] ont permis de démontrer une incidence familiale suggérant un mode de transmission dominante et ont d'ailleurs établi une prévalence dans la transmission de la scoliose variant de 17 à 42 % chez les filles et de 7 à 29 % chez les garçons issus d'un parent atteint de SIA sans qu'il y ait une différence significative selon que la mère ou le père soit affecté d'une scoliose [5,6].…”

Section: Facteurs Génétiquesunclassified

Récents progrès dans l’étiopathogénie de la scoliose idiopathique de l’adolescent et nouveaux concepts moléculaires

et al. 2007

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“…This deformity can involve asymmetry of the shoulders and of the carriage, the presence of a prominent costal hump in the convex region of the curve, and changes in sagittal balance. 1 Multiple studies have analyzed the relationship between lumbar lordosis and thoracic kyphosis. In idiopathic scoliosis, the decrease in thoracic kyphosis is associated with a decrease in lumbar lordosis.…”

Section: Introductionmentioning

confidence: 99%

Parameters for the Evaluation of Cervical Sagittal Balance in Idiopathic Scoliosis

et al. 2017

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Objective: There are no values defined as standard in the literature for the parameters of assessment of cervical sagittal balance in patients with idiopathic scoliosis. This study describes the sagittal cervical parameters in patients with idiopathic scoliosis. Methods: Study carried out in a tertiary public hospital in patients with adolescent idiopathic scoliosis, through the evaluation of panoramic radiographs in lateral view. The Cobb method was used to evaluate cervical lordosis from C2 to C7, distance from the center of gravity (COG) of the skull to C7, measurement of T1 slope, thoracic inlet angle (TIA), neck tilt, and plumb line from C7 to S1 (SVA C7-S1). A statistical analysis was performed, to demonstrate the relationship between the alignment of the thoracic spine in the sagittal plane and the cervical sagittal balance of patients with scoliosis. Results: Thirty-four patients were female (69.4%) and 15 male (30.6%). The mean values for COG-C7 were 0.71 mm (median 0.8 mm/standard deviation [SD]= 0.51 mm). For Cobb C2-C7, the mean was -11.7° (median -10°/SD= 20.4°). The mean slope of T1 was 23.5° (median 25°/ SD= 9.5°). The mean cervical version was 58.8° (median 60°/DP= 15.4°). The mean TIA was 81.8° (median 85°/SD= 16.7°). The mean plumb line C7-S1 was -0.28 (-0.3/SD= 1.0) Conclusion: The analysis of the results showed that the mean values for the cervical lordosis are lower than the values described as normal in the literature, suggesting a loss of sagittal cervical balance in these patients.Keywords: Scoliosis; Postural balance; Spine. 3/DP= 1,0 3/DE= 1,0 RESUMO 6%). A média dos valores para COG-C7 foi 0,71 mm (mediana 0,8 mm/desvio padrão [DP]= 0,51 mm). Para o Cobb de C2-C7, a média foi -11,7° (mediana -10°/DP= 20,4°). A média da inclinação de T1 foi 23,5° (mediana 25°/DP= 9,5°). A média da versão cervical foi 58,8° (mediana 60°/DP= 15,4°). A média do TIA foi 81,8°(mediana 85°/DP= 16,7°). A média da linha de prumo

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Genetic Aspects of Idiopathic Scoliosis

Cited by 155 publications

References 0 publications

Idiopathic scoliosis

Idiopathic scoliosis

Récents progrès dans l’étiopathogénie de la scoliose idiopathique de l’adolescent et nouveaux concepts moléculaires

Parameters for the Evaluation of Cervical Sagittal Balance in Idiopathic Scoliosis

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