Genetic association analysis of ERBB4 polymorphisms with the risk of schizophrenia and SPEM abnormality in a Korean population

Bae, Joon Seol; Pasaje, Charisse Flerida A.; Park, Byung-Lae; Cheong, Hyun Sub; Kim, Jeonghyun; Kim, Jason Yongha; Shin, Joong‐Gon; Park, Chul Soo; Kim, Bong-Jo; Lee, Cheol Soon; Lee, Migyung; Choi, Woojin; Shin, Tai Sun; Hwang, Jaeuk; Shin, Hyoung Doo; Woo, Sung‐Il

doi:10.1016/j.brainres.2012.05.029

Cited by 11 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ERBB4 was one of critical neuron developmental genes and related with SCZ. Genetic association test found that ERBB4 polymorphisms were associated the risk of SCZ [Bae et al, 2012;Lu et al, 2010;Stefanis et al, 2013]. Besides, the interaction of NRG1-ERBB4 had been emerged as biologically plausible SCZ risk factor, modulator of GABAergic and dopaminergic neurotransmission, and as potent regulator of glutamatergic synaptic plasticity [Banerjee et al, 2010;Buonanno, 2010].…”

Section: Discussionmentioning

confidence: 99%

DNA methylation patterns of protein coding genes and long noncoding RNAs in female schizophrenic patients

Liao

Wang

Cheng

et al. 2015

European Journal of Medical Genetics

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

DNA methylation patterns of protein coding genes and long noncoding RNAs in female schizophrenic patients

Liao

Wang

Cheng

et al. 2015

European Journal of Medical Genetics

View full text Add to dashboard Cite

“…The ERBB4 gene is located on human chromosome 2 (2q34) (10). It is one of four members of the erbB receptor tyrosine kinase (RTK) family.…”

Section: Introductionmentioning

confidence: 99%

“…The erbB family contains four genes: erbB1, erbB2, erbB3, and ERBB4 (11,12). In terms of size, ERBB4 is a large gene consisting of approximately 1.16 Mb that includes 28 exons encoding for type 1 transmembrane tyrosine kinase (10,13). There are four isoforms of ERBB4 that have been characterized due to alternative splicing of the ERBB4 transcript (12).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic association analysis of ERBB4 polymorphisms with the risk ofschizophrenia susceptibility in a Jordanian population of Arab descent

2017

View full text Add to dashboard Cite

Background/aim: The ERBB4 gene encodes a transmembrane tyrosine kinase and is considered to be one of the risk genes of schizophrenia. Although there is evidence of the roles of genes and the environment in the etiology of schizophrenia, a comprehensive biological and genetic background of the disease is still lacking. The aim of this study is to assess whether genetic variation in the human ERBB4 gene is associated with vulnerability to schizophrenia in the Jordanian Arab population. Materials and methods:A total of 185 inpatients with schizophrenia participated in this study and 195 healthy genetically homogeneous individuals were also used as controls. Two genetic variants, rs839523 (G/A, intron 2) and rs3748962 (A/G, exon 27), encompassing the ERBB4 gene were genotyped using DNA sequencing. Results:The results revealed a strong and statistically significant genetic association of rs839523 with schizophrenia (P = 0.002 for allele and P = 0.006 for genotype). Conclusion:This study provides strong statistical evidence that there is an association between the ERBB4 gene and schizophrenia in a Jordanian population of Arab descent.

show abstract

“…A total of 113 schizophrenia patients who were able to understand the procedure of the experiment underwent an eye tracking task as described previously (Bae et al 2012). The setting for the SPEM task was a darkened quiet room, wherein the schizophrenia patients were instructed to sit in front of a 19-in.…”

Section: Measurement Of Smooth Pursuit Eye Movement (Spem)mentioning

confidence: 99%

Association analysis of PDE4B polymorphisms with schizophrenia and smooth pursuit eye movement abnormality in a Korean population

Bae

Park

Cheong

et al. 2015

gpb

Self Cite

View full text Add to dashboard Cite

Abstract. Schizophrenia is a debilitating mental disorder with a high heritability rate. Located on chromosome 1p31.3, the human cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B) gene has been considered as an important candidate gene for the risk of schizophrenia. Several genetic association studies reported the association between PDE4B polymorphisms and the risk of schizophrenia in Caucasian, African American, Indian, and Japanese populations. The aim of this study is to examine the association of PDE4B variations with schizophrenia and smooth pursuit eye movement (SPEM) abnormality in a Korean population. A case-control association analysis was carried out by comparing the genotype distribution of eight PDE4B polymorphisms between 457 schizophrenia patients and 386 normal healthy subjects. Differences in the frequency distribution of PDE4B single-nucleotide polymorphisms (SNPs) and haplotypes were analyzed by logistic regression analyses controlling for age as a covariate. Statistical analyses revealed nominal significant associations of rs1040716, rs472952, rs1321177, and rs2144719 with the risk of schizophrenia (p = 0.02~0.05). The rs11208756 polymorphism showed a nominal significant association with SPEM abnormality (p = 0.05). In a meta-analysis with Japanese and Korean populations, three SNPs (rs472952, rs1040716, and rs2180335) revealed significant associations with schizophrenia (meta-p value = 0.0038~0.019). Our results support previously reported association of PDE4B variations with schizophrenia in other populations. The findings in this study add a new evidence for the involvement of PDE4B gene in schizophrenia etiology.

show abstract

Genetic association analysis of ERBB4 polymorphisms with the risk of schizophrenia and SPEM abnormality in a Korean population

Cited by 11 publications

References 22 publications

DNA methylation patterns of protein coding genes and long noncoding RNAs in female schizophrenic patients

DNA methylation patterns of protein coding genes and long noncoding RNAs in female schizophrenic patients

Genetic association analysis of ERBB4 polymorphisms with the risk ofschizophrenia susceptibility in a Jordanian population of Arab descent

Association analysis of PDE4B polymorphisms with schizophrenia and smooth pursuit eye movement abnormality in a Korean population

Contact Info

Product

Resources

About