Genetic Association between Interleukin-4 Receptor Polymorphisms and Cancer Susceptibility: A Meta-Analysis Based on 53 Case-Control Studies

Qi, Yong; Zeng, Taofei; Fan, Song; Zhang, Li; Liang, Chaozhao

doi:10.7150/jca.28137

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…IL-4 is an anti-inflammatory Th2 cytokine that can bind IL-4R to regulate IgE production, immune response, and embryonic implantation [ 13 , 29 , 42 ]. Several studies have reported that polymorphisms of IL-4 and/or IL-4R genes are associated with allergic diseases [ 23 , 24 ], diabetes [ 43 ], cancers [ 36 ], and pregnancy disorders [ 25 , 26 , 27 ]. In the present study, we have verified and elucidated polymorphisms of the porcine IL-4 and IL-4R genes with respect to reproductive performance traits in commercial pigs.…”

Section: Discussionmentioning

confidence: 99%

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Association of IL-4 and IL-4R Polymorphisms with Litter Size Traits in Pigs

Norseeda

Liu

Teltathum³

et al. 2021

Animals

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The interleukin-4 (IL-4) and interleukin-4 receptor (IL-4R) are cytokines that are involved in the immune and reproductive systems. This study aimed to verify the polymorphisms in the porcine IL-4 and IL-4R genes and to assess their effects on litter size traits in commercial pigs. Single nucleotide polymorphisms (SNPs) in the porcine IL-4 and IL-4R genes were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A non-coding SNP of IL-4 g.134993898T > C and a non-synonymous SNP of IL-4R c.1577A > T (amino acid change at position 526, Q526L) were found to be segregating in Landrace sows. The IL-4 g.134993898T > C polymorphism was significantly associated with the number of piglets weaned alive (NWA) trait. The IL-4R c.1577A > T polymorphism was significantly associated with the number born alive (NBA) and NWA traits. Moreover, the accumulation of favorable alleles of these two SNP markers revealed significant associations with the NBA, NWA, and mean weight of piglets at weaning (MWW) traits. These findings indicate that the porcine IL-4 and IL-4R genes may contribute to the reproductive traits of pigs and could be used as candidate genes to improve litter size traits in the pig breeding industry.

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Section: Discussionmentioning

confidence: 99%

“…The polymorphisms of the porcine IL-4R gene have been characterized and reported in the Ensembl database (https://asia.ensembl.org/Sus_scrofa/Info/Index, accessed on 2 September 2020). Moreover, the polymorphisms of IL4R gene are associated with the pregnancy disorders and various cancer types in humans [27,[33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Association of IL-4 and IL-4R Polymorphisms with Litter Size Traits in Pigs

Norseeda

Liu

Teltathum³

et al. 2021

Animals

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“…This increased transcriptional activity is critical for increasing the expression of CD14 gene . Mounting evidence indicates the involvement of gene SNPs in cancer risk …”

Section: Discussionmentioning

confidence: 99%

Association of CD14 gene −260C>T and −561C>T polymorphisms with cancer susceptibility: A meta‐analysis

Guo

Huang

et al. 2020

The Journal of Gene Medicine

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Background: Two polymorphisms, −260C>T (rs2569190) and −561C>T (rs5744455), in the CD14 gene have been implicated in susceptibility to cancer. However, the results remain inconclusive. The current meta-analysis was carried out aiming to confirm the function of these two polymorphisms on the susceptibility of cancer. Methods:We collected eligible studies from databases, including PubMed, EMBASE, CNKI, Wanfang, and VIP (Weipu). We used logistic regression calculation to compute odds ratios (ORs) and 95% confidence intervals (CIs). Results: After strict selection, 24 studies with 5854 cases and 10339 controls for −260C>T and seven studies with 1809 cases and 7289 controls for −561C>T were finally enlisted into our analysis reference material. Pool results revealed that neither −260C>T, nor −561C>T was found to have any association with overall cancer susceptibility. Nevertheless, when stratified by cancer type, we detected a decreased risk associated with other cancers in a heterozygous model (OR = 0.69, 95% CI = 0.51-0.93, p = 0.014) and a dominant model (OR = 0.70, 95% CI = 0.53-0.93, p = 0.012) for −561C>T. An increased risk was found in other cancers under an allele model (OR = 1.29, 95% CI = 1.03-1.62, p = 0.026), in laryngeal cancer under a dominant model (OR = 1.38, 95% CI = 1.11-1.71, p = 0.003) and for a score ≤ 9 under a recessive model (OR = 1.45, 95% CI = 1.09-1.91, p = 0.009) for −561C>T.Conclusions: In the present study, we conclude that the CD14 -260C>T and −561C>T polymorphisms might not be associated with overall cancer risk. Further studies are encouraged to confirm this conclusion. K E Y W O R D SCD14, meta-analysis, polymorphism, susceptibility

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“…According to the updated global estimation in 2018, approximately 42 million people across the world suffered from any type of cancer. 1 Although great efforts have been made to clarify the mechanisms of carcinogenesis, much remains unknown. Many risk factors that promote carcinogenesis have been identified, such as family history of cancer, dietary habits, alcohol use, obesity, smoking, and occupational exposures.…”

Section: Introductionmentioning

confidence: 99%

Association between ACE A240T polymorphism and cancer risk: a meta-analysis

et al. 2019

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Objectives The relationship between the A240T polymorphism in the angiotensin-converting enzyme ( ACE) gene and cancer risk remains controversial. Therefore, we conducted a meta-analysis of relevant studies from the published literature. Methods We comprehensively searched available databases to identify eligible studies on the relationship of ACE A240T polymorphism with cancer risk. We calculated pooled odds ratios (OR) with 95% confidence intervals (CI) and then evaluated heterogeneity and publication bias. Results Eight case-control studies were identified from five articles. Results showed that the ACE A240T polymorphism was related to cancer risk (AT vs AA: OR 2.14, 95% CI: 1.51–3.04; TT vs AA: OR 1.07, 95% CI: 0.90–1.27; recessive model: OR 0.48, 95% CI: 0.31–0.77; dominant model: OR 2.13, 95% CI: 1.54–2.97). The same conclusion was made for subgroup analysis by race or cancer type. In the subgroup analysis by quality score assessment, the ACE A240T polymorphism contributed to cancer risk in high-quality studies but not in low-quality studies. Conclusion The A240T polymorphism in the ACE gene might be related to the risk of cancer. Nevertheless, large-scale studies should be performed to obtain convincing evidence on the roles of ACE A240T polymorphism on cancer risk.

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Genetic Association between Interleukin-4 Receptor Polymorphisms and Cancer Susceptibility: A Meta-Analysis Based on 53 Case-Control Studies

Cited by 6 publications

References 47 publications

Association of IL-4 and IL-4R Polymorphisms with Litter Size Traits in Pigs

Association of IL-4 and IL-4R Polymorphisms with Litter Size Traits in Pigs

Association of CD14 gene −260C>T and −561C>T polymorphisms with cancer susceptibility: A meta‐analysis

Association between ACE A240T polymorphism and cancer risk: a meta-analysis

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