Genetic Association Family‐Based Studies and Preeclampsia

Response to Commentary: Genetic Association Family‐Based Studies and Preeclampsia

“…As Infante‐Rivard notes, genetic case–control studies can be susceptible to bias and false positives from population stratification . Since our results were largely negative, we were not awash in false positives.…”

“…As Infante-Rivard notes, genetic case-control studies can be susceptible to bias and false positives from population stratification. 3 Since our results were largely negative, we were not awash in false positives. Nevertheless, we share this concern and therefore conducted sensitivity analyses where we limited analysis to those with similar ancestry markers; the results did not materially change.…”

“…An overarching goal of our study was to investigate genes that may be mechanistically involved in a biological response to smoking, as well as to assess gene‐smoking interactions. In a case‐parent trio design, one can investigate multiplicative interactions between a genetic variant and another covariate, but as Infante‐Rivard acknowledges in her commentary, with the case‐parent design one cannot investigate main effects of non‐genetic covariates.…”