Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients

Shahsavari, Gholamreza; Nouryazdan, Negar; Adibhesami, Glavizh; Birjandi, Mehdi

doi:10.1007/s11033-020-05585-2

Cited by 10 publications

(6 citation statements)

References 39 publications

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“…Diabetes mellitus is one of the growing chronic diseases worldwide that is closely related to cardiovascular disease [13,14]. In the present study, which aimed to evaluate the serum levels of sd-LDL, MDA, TCA, and AOPP in type 2 diabetic patients with atherosclerosis in comparison with healthy individuals, we observed that sd-LDL, MDA, and AOPP in DAP group were signi cantly higher in comparison with DP group, while TCA level was signi cantly lower.…”

Section: Discussionmentioning

confidence: 53%

Evaluation of Sd-LDL, MDA, AOPPs , Atherogenic index as Cardiovascular Risk Factors among Diabetic Atherosclerosis Patients

Shahsavari

Nouryazdan

Nasiri

et al. 2022

Preprint

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Objectives: The present study investigates the relationship between serum levels of Malondialdehyde (MDA), Small dense LDL cholesterol (sd-LDL-C), advanced products of protein oxidation (AOPP), Total antioxidant capacity (TCA) and Atherogenic indices in type 2 diabetic patients with atherosclerosis compared with healthy individuals. Results: In this study, 50 healthy individuals and 60 patients were selected among the subjects referred to Shahid Madani Hospital. Atherosclerosis was determined with standard gold angiography. The serum levels of sd-LDL, MDA, AOPP, and TCA were evaluated by a specific method. Logistic regression analysis and receiver operating characteristic (ROC) curves were used to examine the association between risk factors and disease. Multivariate Logistic regression analysis showed that higher Triglycerides-Glucose (TYG) and atherogenic index of plasma (AIP), were associated with a higher risk of diabetic atherosclerosis patients compared with other risk factors (OR = 19.92, 95% CI: 6.65-39.67, p < 0.001) and (OR = 12.05, 95% CI: 4.88-29.70, p < 0.001), respectively. The area under the curve of disease predicted by sd-LDL and TYG was higher than other parameters (p < 0.001). The findings indicated that increased sd-LDL, TYG, and AIP might be useful for identifying individuals at higher risk of diabetic atherosclerosis patients.

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Section: Discussionmentioning

confidence: 53%

Evaluation of Sd-LDL, MDA, AOPPs , Atherogenic index as Cardiovascular Risk Factors among Diabetic Atherosclerosis Patients

Shahsavari

Nouryazdan

Nasiri

et al. 2022

Preprint

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“…The PON1 rs854560 T allele corresponded with a higher risk of CHD-related death in non-DM men 18 , an increased risk of CHD in Iranian patients with atherosclerosis 41 , the higher prevalence of ischemic cerebral stroke in the entire HD population 32 and end-stage NIDDM nephropathy individuals 27 , but not with cardiovascular, cardiac, or vascular mortality in the whole HD subjects 32 . Surprisingly, in this study, the rs854560 T allele was inversely associated with cardiovascular mortality in non-DM smokers.…”

Section: Discussionmentioning

confidence: 95%

Paraoxonase 1 gene variants concerning cardiovascular mortality in conventional cigarette smokers and non-smokers treated with hemodialysis

Grzegorzewska

Ostromecka

Świderska

et al. 2021

Sci Rep

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Cigarette smoking effects might correspond with paraoxonase 1 gene (PON1) single nucleotide variants (SNVs). We investigated the association of PON1 rs705379, rs854560, and rs662 with cardiovascular mortality in hemodialysis (HD) patients concerning conventional cigarette smoking. Cardiovascular, cardiac, coronary heart disease (CHD)- and non-CHD-related deaths were analyzed in 206 HD cigarette smokers and 659 HD non-smokers. P-values were adjusted for sex, age, and high-density lipoprotein cholesterol. Among all smokers, the rs705379 TT genotype was associated with cardiovascular (P = 0.028), cardiac (P = 0.046), and cardiac non-CHD-related (P = 0.001) mortality. Non-diabetic smokers showed similar qualitative significance to all smokers concerning mentioned death rates (P-values 0.011, 0.044, and 0.009, respectively). In diabetic non-smokers, the rs705379 T allele correlated with CHD-related deaths (P = 0.020). The rs854560 T allele was associated with lower cardiovascular mortality in non-diabetic smokers (P = 0.008). The rs854560 TT genotype showed a negative non-significant correlation with non-CHD-related cardiac death in all non-smokers (P = 0.079). In diabetic smokers, the rs662 G allele was associated with higher cardiac mortality (P = 0.005). In all non-smokers and non-diabetic non-smokers, the rs662 G correlated with cardiovascular deaths (P = 0.020 and P = 0.018, respectively). Genotyping PON1 SNVs may help argue HD smokers harboring the rs705379 TT genotype or T allele and non-smokers possessing the rs662 G allele for prevention against cardiovascular diseases. These groups are more burdened genetically for cardiovascular mortality.

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“…17 Como a DAC é uma doença importante em relação à mortalidade e os estudos mostram que existe uma associação entre PON1 e DAC, decidiu-se investigar essa associação na sociedade iraniana, principalmente no nordeste do país. 18 Existem poucos estudos sobre a associação entre o genótipo ou fenótipo de PON1 e DAC no nordeste do Irã, [19][20][21] e a atividade enzimática sérica não foi estudada juntamente com polimorfismos. O objetivo do presente estudo foi avaliar a associação entre polimorfismos de PON1 e atividade da paraoxonase com DAC em adultos iranianos que vivem no nordeste do país.…”

Section: Introductionunclassified

Associação do Genótipo e Fenótipo da Paraoxonase-1 com Angiografia Positiva para Doença Arterial Coronariana

Soflaei¹,

Baktashian²,

Moghaddam³

et al. 2022

Arquivos Brasileiros De Cardiologia

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Fundamento: Tem sido demonstrado que um aumento dos níveis séricos de PON1 é protetor contra vários distúrbios. Foi relatado que vários polimorfismos de nucleotídeo único (SNPs, single nucleotide polymorphisms) do gene PON1 estão associados a níveis e atividade de proteínas enzimáticas séricas. Objetivos: Investigar a associação de SNPs do PON1 e atividade da paraoxonase sérica com a doença arterial coronariana (DAC). Métodos: Foram estudados 601 pacientes não relacionados submetidos à angiografia coronária, incluindo aqueles com estenose >50% (N=266) e aqueles com estenose <30% (N=335). Os SNPs rs662 e rs840560 do gene da paraoxonase foram determinados utilizando o método ARMS-PCR e o SNP rs705379 foi genotipado utilizando análise de PCR-RFLP. A atividade da paraoxonase sérica foi medida utilizando paraoxon como substrato. O valor de p<0,05 foi considerado significante. Resultados: A atividade da paraoxonase sérica não foi significativamente diferente entre os grupos de estudo. Após ajuste para idade, sexo, hipertensão, diabetes mellitus e dislipidemia, o genótipo GG e o modelo codominante de rs662 foram positivamente associados a uma angiografia positiva (respectivamente, OR = 2,424, IC 95% [

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Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients

Cited by 10 publications

References 39 publications

Evaluation of Sd-LDL, MDA, AOPPs , Atherogenic index as Cardiovascular Risk Factors among Diabetic Atherosclerosis Patients

Evaluation of Sd-LDL, MDA, AOPPs , Atherogenic index as Cardiovascular Risk Factors among Diabetic Atherosclerosis Patients

Paraoxonase 1 gene variants concerning cardiovascular mortality in conventional cigarette smokers and non-smokers treated with hemodialysis

Associação do Genótipo e Fenótipo da Paraoxonase-1 com Angiografia Positiva para Doença Arterial Coronariana

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