Genetic associations with asthma and virus-induced wheezing: a systematic review

Pinto, Leonardo Araújo; Stein, Renato T.; Ribeiro, José Dirceu

doi:10.1590/s1806-37132009001200010

Cited by 9 publications

(9 citation statements)

References 46 publications

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“…Other studies found no association between delivery by CS and allergic rhinitis: Park e et al ( OR = 1.14); Xu e et al ( OR = 1.28); Mallen e et al ( OR = 2.82) [ 10 , 23 , 24 ]. Parental history of atopy is considered an important risk factor for the development of asthma and atopic diseases [ 25 ], and is a potential effect modifier in the evaluation of the association between delivery by CS, asthma, allergic rhinitis and atopic sensitization [ 14 , 15 , 17 ]. In our study, CS was associated allergic rhinitis and chronic rhinitis only in children with parental history of asthma, which suggests that the association between CS and allergic rhinitis and CS and chronic rhinitis could be dependent on the genetic predisposition.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of allergic rhinitis among children delivered by cesarean section: a cross-sectional study nested in a birth cohort

Brandão

Vieira

et al. 2016

BMC Pediatr

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BackgroundFew studies have evaluated the association between delivery by cesarean section (CS) and asthma, allergic rhinitis and chronic rhinitis and whether this association is different in children with and without a family history of asthma. This study aims to investigate whether children born by CS have a higher chance to develop asthma, allergic rhinitis and chronic rhinitis and to evaluate the influence of parental history of asthma on these associations.MethodsThis is a cross-sectional study of 672 children nested in a birth cohort evaluated at 6-years of age. Asthma and chronic/allergic rhinitis were identified by means of the mother’s responses to the ISAAC questionnaire. The association between CS, asthma, chronic rhinitis and allergic rhinitis was evaluated by multivariable logistic regression. The evidence of effect modification of parental history of asthma on the association CS and outcomes was examined by introducing interactions terms in the logistic regression models adjusting for confounders.ResultsAsthma was not associated with birth by CS irrespective of parental history of asthma (odds ratio (OR) 1.03; 95 % CI 0.61–1.74). Chronic rhinitis and allergic rhinitis were both significantly associated with birth by CS but only in the subgroup of children with by parental history of asthma (OR 1.56; 95 % CI 1.04–2.34) and (OR 1.60; 95 % CI 1.01–2.55) respectively, after adjustment for confounders. The parental history of asthma was a effect modifier in the association between CS, chronic rhinitis and allergic rhinitis (p for effect modification = 0.10 and 0.02, respectively).ConclusionCS increases the risk of chronic rhinitis and allergic rhinitis in children at 6 years of age with parental history of asthma. Health professionals must be alerted with regard to the increased risk of allergic rhinitis and made aware this is another reason to avoid unnecessary CS.

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Section: Discussionmentioning

confidence: 99%

Increased risk of allergic rhinitis among children delivered by cesarean section: a cross-sectional study nested in a birth cohort

Brandão

Vieira

et al. 2016

BMC Pediatr

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“…A C-T substitution at base pair 260 of the 5' flanking region of CD14 -260 (rs2569190, also known as CD14 -159 C/T) is the most widely studied of the CD14 polymorphisms. The rs2569190 single-nucleotide polymorphism has been investigated as a candidate genetic locus in asthma and allergic disease (Pinto et al, 2009). Among skin test-positive atopic children, Baldini et al (1999) found that compared with subjects carrying the CC and CT genotypes, subjects with the TT genotype showed significantly higher levels of soluble CD14 (sCD14) than either the CC or CT genotype carriers.…”

Section: Discussionmentioning

confidence: 99%

Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. CD14 is involved in primary immune and inflammatory responses. The -159 C/T variation in the CD14 gene plays an important role in regulating CD14 expression and has been associated with the susceptibility to various diseases, including allergies. In this study, we examined the association between the C-159T polymorphism and atopic asthma susceptibility in children from Southeastern China. The study population included 746 unrelated children of Chinese Han nationality (362 patients with atopic asthma and 384 healthy controls). CD14 gene polymorphisms were identified by direct sequencing of polymerase chain reaction products. Total immunoglobulin E (IgE) levels in human serum samples were determined using an enzymelinked immunosorbent assay. Individuals carrying the TT genotypes for rs2569190 were significantly associated with an increased risk of atopic asthma compared with those carrying the wild-type homozygous CC genotypes [adjusted odds ratio (OR) by gender and age, from 1.075- 2.398, P = 0.025]. Total serum IgE levels in TT genotype carriers were significantly higher than those in CC genotype carriers in atopic asthma patients (286.3 ± 161.5 IU/mL vs 248.3 ± 147.8 IU/mL). Our data suggest that the CD14 TT genotype may be a genetic susceptibility marker for atopic asthma in Chinese Han children.

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“…SNPs in genes coding for interleukin (IL)-8, IL-19, IL-20, IL-13 mannose-binding lectin, interferon-gamma, and a regulated on activation, normal T cell expressed and secreted polymorphism have been associated with subsequent wheeze after RSV lower respiratory tract infection in term-born infants ( 14 ). Utilizing the inpatient database of severe RSV infection or without, we compared MARCO rs1318645 [GenBank access number NT_005403.18 2 ] polymorphism and risk of recurrent wheezing or recurrent airway infections during childhood.…”

Section: Discussionmentioning

confidence: 99%

Macrophage Receptor With Collagenous Structure Polymorphism and Recurrent Respiratory Infections and Wheezing During Infancy: A 5-Years Follow-Up Study

et al. 2021

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Background: Recurrent wheezing is a common clinical manifestation in childhood, and respiratory syncytial virus infection is a well-known risk factor. However, the genetic background favoring the development of recurrent wheezing is not fully understood. A possible role of macrophage receptor with collagenous gene (MARCO) polymorphism has been recently proposed.Objective: To investigate a correlation between MARCO rs1318645 polymorphisms and susceptibility to recurrent wheezing during childhood.Methods: We prospectively recruited 116 infants, of which 58 with respiratory syncytial virus bronchiolitis and 58 controls hospitalized at Regina Margherita Children's Hospital, Turin, Italy, between November 2014 and April 2015. All subjects were investigated for MARCO rs1318645 polymorphisms in the first period of life. Genotyping of rs1318645 was carried out by TaqMan mismatch amplification mutation assay real-time polymerase chain reaction procedure. Subjects were then enrolled in a 5-year follow-up study to monitor the occurrence of wheezing and respiratory infections.Results: The analysis of MARCO rs1318645 of allelic frequencies shows an increasingly significant risk to develop recurrent infection (p = 0.00065) and recurrent wheezing (p = 0.000084) with a wild-type C allele compared with a G allele. No correlation was found between wheezing and past respiratory syncytial virus infection (p = 0.057) and for a history of atopy in the family (p = 0.859).Conclusion: Our finding showed that subjects with C allelic MARCO rs1318645 polymorphism are at higher risk for recurrent infection and wheezing episodes during the first 5 years of life. Future studies of genetic associations should also consider other types of polymorphisms.

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Genetic associations with asthma and virus-induced wheezing: a systematic review

Cited by 9 publications

References 46 publications

Increased risk of allergic rhinitis among children delivered by cesarean section: a cross-sectional study nested in a birth cohort

Increased risk of allergic rhinitis among children delivered by cesarean section: a cross-sectional study nested in a birth cohort

Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study

Macrophage Receptor With Collagenous Structure Polymorphism and Recurrent Respiratory Infections and Wheezing During Infancy: A 5-Years Follow-Up Study

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