Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West

Ikegami, Hiroshi; Noso, Shinsuke; Babaya, Naru; Hiromine, Yoshihisa; Kawabata, Yumiko

doi:10.1900/rds.2008.5.64

Cited by 31 publications

(31 citation statements)

References 47 publications

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“…In the present study, we found that participants with HLA‐DRB1*09:01 or HLA‐DQB1*03:03 were more likely to be associated with GADA‐ELISA positivity. HLA‐DRB1*09:01‐DQB1*03:03 have been associated with type 1 diabetes in Japan and East Asia. These HLA haplotypes account for 14.3% of the general population in Japan, but are rare in Caucasians.…”

Section: Discussionmentioning

confidence: 99%

Clinical and genetic characteristics of people with type 1 diabetes who have discrepancies in titers of anti‐glutamic acid decarboxylase antibody measured by radioimmunoassay and enzyme‐linked immunosorbent assay

Takagi

Miura

Hoshina

et al. 2019

J of Diabetes Invest

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Aims/Introduction The aim of the present study was to compare the clinical and genetic characteristics between people with type 1 diabetes who were positive and negative for autoantibodies against glutamic acid decarboxylase (GADA) measured by enzyme‐linked immunosorbent assay (ELISA) with low‐titer GADA measured by radioimmunoassay. Materials and Methods Among Japanese people with type 1 diabetes in whom GADA were measured by both ELISA and radioimmunoassay, those who had low titers of GADA measured by radioimmunoassay (1.5–10 U/mL), regardless of positivity for GADA measured by ELISA, were studied. There were 65 participants with acute‐onset type 1 diabetes and 30 participants with slowly progressive insulin‐dependent diabetes mellitus. Clinical characteristics and human leukocyte antigen types were compared in ELISA‐positive (≥5 U/mL) and ELISA‐negative participants. Endogenous insulin secretion was evaluated by C‐peptide index. Results Among participants with slowly progressive insulin‐dependent diabetes mellitus, postprandial C‐peptide index was significantly higher in ELISA‐negative participants than in ELISA‐positive participants (r = 0.619, P = 0.002). Among 52 participants whose human leukocyte antigen typing was carried out, all of the participants with slowly progressive insulin‐dependent diabetes mellitus who had DRB1*09:01 were positive by GADA‐ELISA (P = 0.021). In acute‐onset type 1 diabetes participants, there were no significant differences for the C‐peptide index and human leukocyte antigen genotypes. Conclusions The difference in the positivity for GADA‐ELISA might reflect cytotoxicity toward pancreatic β‐cells and preservation of endogenous insulin secretion in people with slowly progressive insulin‐dependent diabetes mellitus. We also suggest that the difference in the GADA‐ELISA‐specific epitope depends on the human leukocyte antigen genotype.

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Section: Discussionmentioning

confidence: 99%

Clinical and genetic characteristics of people with type 1 diabetes who have discrepancies in titers of anti‐glutamic acid decarboxylase antibody measured by radioimmunoassay and enzyme‐linked immunosorbent assay

Takagi

Miura

Hoshina

et al. 2019

J of Diabetes Invest

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“…Not all populations display the same HLA DR/DQ as T1D susceptibility haplotypes. For instance, considering two-locus haplotypes, DRB1*0301-DQB1*0201 and DRB1*0401-DQB1*0302 are positively associated with T1D in European populations, whereas DRB1*0405-DQB1*0401 and DRB1*0901-DQB1*0303 haplotypes are associated with the disease in most East Asian populations (Ikegami et al, 2008). In populations of European origin, the threelocus haplotypes DRB1*04-DQA1*0301-DQB1*0302 and DRB1*03-DQA1*0501-DQB1*0201 have been shown to play a predominant role in conferring disease susceptibility (Fernando et al, 2008) being heterozygosity for both haplotypes the greatest known genetic risk for T1D.…”

Section: Population Genetic Background Influences T1d Incidencementioning

confidence: 99%

Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes

Diaz-Horta¹,

Sarmiento²,

Baj³

et al. 2011

Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy

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“…DRB1*04:01 was reported to be associated with alopecia areata (22,23), as well as type 1 diabetes (24), in the Caucasian population. In the present study, the association of this haplotype with alopecia areata could not be studied because of the very low frequency of DRB1*04:01 (Ͻ1% of the general population) in Japanese (25). These data suggest that the presence or absence of HLA haplotypes in each ethnic group affects autoimmunity to a second target organ in patients with an organ-specific autoimmune disease, such as thyroid autoimmunity in patients with alopecia areata.…”

Section: Discussionmentioning

confidence: 75%

Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

Noso

Park

Babaya

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

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Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West

Cited by 31 publications

References 47 publications

Clinical and genetic characteristics of people with type 1 diabetes who have discrepancies in titers of anti‐glutamic acid decarboxylase antibody measured by radioimmunoassay and enzyme‐linked immunosorbent assay

Clinical and genetic characteristics of people with type 1 diabetes who have discrepancies in titers of anti‐glutamic acid decarboxylase antibody measured by radioimmunoassay and enzyme‐linked immunosorbent assay

Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes

Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

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