Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

Noso, Shinsuke; Park, Choongyong; Babaya, Naru; Hiromine, Yoshihisa; Harada, Takeshi; Ito, Hiroyuki; Taketomo, Yasunori; Kanto, Kousei; Oiso, Naoki; Kawada, Akira; Suzuki, Tamio; Kawabata, Yumiko; Ikegami, Hiroshi

doi:10.1210/jc.2014-3985

Cited by 32 publications

(30 citation statements)

References 32 publications

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“…Noso et al reported an association of thyroid autoimmunity with alopecia areata, an autoimmune disease directed to hair follicles. The authors found a positive association of DRB1*15:01-DQB1*06:02 with alopecia areata in TSH (thyrotropin) receptor antibody-positive patients indicating that this haplotype confers susceptibility to thyroid autoimmunity, suggesting a common etiology and susceptibility between autoimmune thyroiditis and alopecia areata 14 .…”

Section: Discussionmentioning

confidence: 95%

Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross‐sectional retrospective study

et al. 2017

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Background Current information indicates that psoriasis is a metabolic disorder with systemic manifestations. Reports have revealed an association between psoriasis and several chronic autoimmune disorders. For one of these disorders, Hashimoto’s thyroiditis, there are scarce, and relatively unconfirmed, reports of an association with psoriasis. We sought to determine if such an association is detectable in a large medical record data repository. Methods We searched one institution’s electronic medical record data repository from January 2010 to December 2013. Patients were identified by ICD-9 codes (psoriasis: 696.0; 696.1, Hashimoto’s thyroiditis: 245.2). Only data from patients with laboratory-confirmed Hashimoto’s thyroiditis (anti-thyroid peroxidase (anti-TPO) antibodies; thyroglobulin antibodies; serum TSH and free T3) were eligible for inclusion. Logistic regression analysis was used to obtain an odds ratio (OR) to establish an association between psoriasis and Hashimoto’s thyroiditis. Stratified analyses were performed to test for confounding variable and effect modification. Results Medical records for 856,615 individuals with documented encounters between January 1, 2010 and December 31, 2013 were detected. 9,654 had a diagnosis of psoriasis and 1,745 had a diagnosis of Hashimoto’s thyroiditis. Of these, 41 subjects were diagnosed with both conditions. A significant association existed for psoriasis and Hashimoto’s thyroiditis, even after adjusting for confounding variables that included sex, age, psoriatic arthropathy and the use of systemic anti-psoriatic agents (OR=2.49; 95%CI 1.79–3.48; p <0.0001). Conclusions This association has broad clinical impact and deserves further attention with regards to patient care, clinical research, and developmental therapeutics.

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Section: Discussionmentioning

confidence: 95%

Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross‐sectional retrospective study

et al. 2017

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“…Furthermore, results vary among studies. Positive thyroglobulin antibodies were found in 22–46% of patients with AA and positive thyroid peroxidase antibodies were found in 9–48% of patients with AA . Abnormal thyroid function tests were found in 8.9–27% of patients with AA .…”

Section: Discussionmentioning

confidence: 96%

“…However, a genome‐wide association study in patients with AA revealed several risk loci in common with other autoimmune diseases, in particular cytotoxic T‐lymphocyte‐associated protein 1, interleukin (IL)‐2/IL‐21, IL‐2RA and genes critical to regulatory T‐cell maintenance . Another Japanese study suggested that specific human leukocyte antigen (HLA) haplotypes contribute to autoimmunity against the thyroid gland in AA . In addition to genetic aspects, the development of AA could also have systemic effects on the thyroid gland .…”

Section: Discussionmentioning

confidence: 99%

Alopecia areata and overt thyroid diseases: A nationwide population‐based study

Han

Lee

Noh

et al. 2018

The Journal of Dermatology

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An association between alopecia areata (AA) and other autoimmune diseases has been reported. We investigated the associations between AA and overt autoimmune thyroid diseases. A nationwide, population-based, cross-sectional study was performed using the Korea National Health Insurance claims database. We defined patients with AA as those whose records showed at least four physician contacts in which AA, alopecia totalis (AT) or alopecia universalis (AU) was the principal diagnosis. We also established an age- and sex-matched control group without AA. In a subgroup analysis, patients with AT or AU were classified into the severe AA group, and the remainder were classified into the mild to moderate AA group. Patients with AA were at an increased risk of Graves' disease (odds ratio [OR], 1.415; 95% confidence interval [CI], 1.317-1.520) and Hashimoto thyroiditis (OR, 1.157; 95% CI, 1.081-1.237), and the associations were stronger in the severe AA group (Graves' disease: OR, 1.714; 95% CI, 1.387-2.118; Hashimoto thyroiditis: OR, 1.398; 95% CI, 1.137-1.719). In conclusion, AA was significantly associated with overt autoimmune thyroid diseases. Furthermore, the risk was much higher in the severe AA group.

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“…Therefore, we searched for recent reports on screening studies of TgAb and TPOAb. To avoid the influence of diseases themselves, we only considered studies done on healthy control subjects in various regions in different countries [24][25][26][27][28][29][30][31][32][33][34][35][36][37]. In healthy subjects, the incidence of positive TgAb or TPOAb is …”

Section: Discussionmentioning

confidence: 99%

Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases

et al. 2017

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Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

Abstract: AA was associated with thyroid autoimmunity but not islet autoimmunity, which correlated with class II HLA haplotypes susceptible or resistant to each autoimmune disease.

Cited by 32 publications

References 32 publications

Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross‐sectional retrospective study

Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross‐sectional retrospective study

Alopecia areata and overt thyroid diseases: A nationwide population‐based study

Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases

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