Genetic characterization of canine distemper virus from wild and domestic animal submissions to diagnostic facilities in Canada

Giacinti, Jolene A.; Pearl, David L.; Ojkić, Davor; Campbell, G. Douglas; Jardine, Claire M.

doi:10.1016/j.prevetmed.2021.105535

Cited by 12 publications

(11 citation statements)

References 39 publications

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“…Host immune response to CDV may also differ based on the CDV variant to which individuals were exposed (Anis et al 2018a). In Ontario, there are multiple cocirculating CDV variants in raccoons (Giacinti et al 2022). Because our study detected antibodies, not virus, we were unable to determine CDV infection status or identify the CDV variant to which individuals were exposed.…”

Section: Discussionmentioning

confidence: 99%

“…Increasing awareness of CDV in diverse hosts, and of changing CDV dynamics (Beineke et al 2015; Riley and Wilkes 2015; Viana et al 2015), have led to renewed interest in the ecology of CDV in wild animal populations. Many wildlife CDV studies have focused on documenting prevalence across different populations or geographies (Hoff et al 1974; Roscoe 1993; Mitchell et al 1999), understanding pathogenesis and epidemiologic characteristics (Pfeffermann et al 2018; Needle et al 2019), and characterizing genetic variability (Anis et al 2018b; Giacinti et al 2022). Few longitudinal serologic studies have been conducted in wildlife.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Canine Distemper Virus Ecology: Insights From a Longitudinal Serologic Study in Wild Raccoons (Procyon Lotor)

Giacinti

Pearl

Ojkić

et al. 2023

Journal of Wildlife Diseases

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Canine Distemper Virus Ecology: Insights From a Longitudinal Serologic Study in Wild Raccoons (Procyon Lotor)

Giacinti

Pearl

Ojkić

et al. 2023

Journal of Wildlife Diseases

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“…It appears these genotypes were introduced into different parts of the world and have undergone purifying selection independently but in parallel, resulting in geographic clusters or lineages and have been named based on their original geographic locations at time of discovery. These lineages include America-1 (contains almost all commercially available vaccine strains), America-2, America-3, South America/North America-4, America-5, Canada-1, Canada-1, Asia-1, Asia-2, Asia-3, Asia-4, Asia-5, Asia-6, Caspian, Europe/South America-1, South America-2, South America-3, Europe Wildlife, Arctic-like, Rockborn-like (vaccine strain), Africa-1, Africa-2, and Australia [ 32 , 40 , 41 , 42 ].…”

Section: Species-jumping (Host Range Specificity)mentioning

confidence: 99%

Canine Distemper Virus in Endangered Species: Species Jump, Clinical Variations, and Vaccination

Wilkes

2022

Pathogens

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Canine morbillivirus (Canine distemper virus, CDV) is the cause of distemper in a large number of different species, some of which are endangered. The clinical outcome associated with infection is variable and based on many factors, including the host species, the immune response of the individual animal to the infection, and variation in virus tropism and virulence. Unfortunately, the viral characteristics associated with virulence versus attenuation are not fully characterized, nor are the specific mutations that allow this virus to easily move and adapt from one species to another. Due to its wide host range, this virus is difficult to manage in ecosystems that are home to endangered species. Vaccination of the domestic dog, historically considered the reservoir species for this virus, at dog-wildlife interfaces has failed to control virus spread. CDV appears to be maintained by a metareservoir rather than a single species, requiring the need to vaccinate the wildlife species at risk. This is controversial, and there is a lack of a safe, effective vaccine for nondomestic species. This review focuses on topics that are paramount to protecting endangered species from a stochastic event, such as a CDV outbreak, that could lead to extinction.

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“…It is a negative-sense RNA virus belonging to the Paramyxoviridae family and Morbillivirus genus, which contains viruses with epidemiological relevance to humans and animals [3,4]. Based on H-gene sequences, CDV strains have been classified into at least 21 major genetic lineages: America-1, America-2, North America-3, South America/North America-4, America-5, Canada 1 and 2, Asia-1, Asia-2, Asia-3, Asia-4, Asia-5, Asia 6, Europe Wildlife, Arctic, Africa-1, Africa-2, Europe-1/South America-1, South America-2, South America-3 and Rockborn-like [5][6][7][8][9][10][11]. CDV creates a conservation threat to endangered species globally due to its ability to jump between multiple species [1,12].…”

Section: Introductionmentioning

confidence: 99%

The First Report and Phylogenetic Analysis of Canine Distemper Virus in Cerdocyon thous from Colombia

Echeverry‐Bonilla

Buriticá-Gaviria

Orjuela-Acosta

et al. 2022

Viruses

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Canine distemper virus (CDV) is the etiological agent of a highly prevalent viral infectious disease of domestic and wild carnivores. This virus poses a conservation threat to endangered species worldwide due to its ability to jump between multiple species and produce a disease, which is most often fatal. Although CDV infection has been regularly diagnosed in Colombian wildlife, to date the molecular identity of circulating CDV lineages is currently unknown. Our aim was to evaluate the presence and phylogenetic characterization of CDV detected in samples from naturally infected Cerdocyon thous from Colombia. We sequenced for the first time the CDV infecting wildlife in Colombia and demonstrated the presence of South America/North America-4 Lineage with a higher relationship to sequences previously reported from domestic and wild fauna belonging to the United States of America. Our results are crucial for the understanding of the interspecies transmission of CDV in the domestic/wild interface and for the prevention and control of such an important multi-host pathogen.

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Genetic characterization of canine distemper virus from wild and domestic animal submissions to diagnostic facilities in Canada

Cited by 12 publications

References 39 publications

Canine Distemper Virus Ecology: Insights From a Longitudinal Serologic Study in Wild Raccoons (Procyon Lotor)

Canine Distemper Virus Ecology: Insights From a Longitudinal Serologic Study in Wild Raccoons (Procyon Lotor)

Canine Distemper Virus in Endangered Species: Species Jump, Clinical Variations, and Vaccination

The First Report and Phylogenetic Analysis of Canine Distemper Virus in Cerdocyon thous from Colombia

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