Genetic characterization of type A foot-and-mouth disease virus 3A region in context of the reemergence of VP359-deletion lineage in India

Mohapatra, Jajati K.; Sahu, Abhipsa; Pandey, Laxmi; Sanyal, Aniket; Hemadri, D.; Pattnaik, Bramhadev

doi:10.1016/j.meegid.2009.01.009

Cited by 7 publications

(4 citation statements)

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“…A lineage specific change noticed at position 44 in 3A region of lineage VIIb (Q 44 ? H) was speculated to be due to selection pressure being exerted to fix advantageous substitutions in the viral population in a lineage specific manner [47]. Though all the isolates of lineage VIIb of current study possessed the same substitution, similar change was also noticed in one non-deletion group isolate.…”

Section: Recombination Analysissupporting

confidence: 56%

Comparative complete genome analysis of Indian type A foot-and-mouth disease virus field isolates

et al. 2011

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Comparative complete genome analysis of 17 serotype A Indian field isolates representing different genotypes and sub-lineages is presented in this report. Overall 79% of amino acids were invariant in the coding region. Chunk deletion of nucleotide was observed in S and L fragment of 5'-UTR. More variability which is comparable to that of capsid coding region was found in L and 3A region. Functional motifs and residues critical for virus biology were conserved most. Polyprotein cleavage sites accepted few changes. Many sites were detected to be under positive selection in L, P1, 2C, 3A, 3C, and 3D region and of which some are functionally important and antigenically critical. Genotype/lineage specific signature residues could be identified which implies evolution under different selection pressure. Transmembrane domain could be predicted in 2B, 2C, 3A, and 3C proteins in agreement with their membrane binding properties. Phylogenetic analysis at complete coding region placed the isolates in genotype IV, VI, and VII and two broad clusters comprising VP3(59)-deletion and non-deletion group within genotypes VII. The VP3(59)-deletion group has diversified genetically with time giving rise to three lineages. Incongruence in tree topology observed for different non structural protein coding region and UTRs-based phylogeny indicate suspected recombination.

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Section: Recombination Analysissupporting

confidence: 56%

Comparative complete genome analysis of Indian type A foot-and-mouth disease virus field isolates

et al. 2011

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“…The A/G‐18 lineage originated in northern areas of India ( p ~= 1.0) in 1990, 95% CI [1988–1991], and subsequently spread widely to other areas of India. The A/G‐18 lineage is comprised of two groups: the A/G‐18 VP3 59 deletion and A/G‐18 VP3 59 non‐deletion, reflecting the non‐deletion of an amino acid at site 59 of the VP3 gene region (Jangra, Tosh, Sanyal, Hemadri, & Bandyopadhyay, ; Mohapatra et al., ). The A/G‐18 VP3 59 non‐deletion sublineage spread from northern India into southern India in 1995, 95% CI [1994–1996].…”

Section: Resultsmentioning

confidence: 99%

Dynamics of widespread foot‐and‐mouth disease virus serotypes A, O and Asia‐1 in southern Asia: A Bayesian phylogenetic perspective

Brito

Mohapatra

Subramaniam

et al. 2017

Transbound Emerg Dis

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Foot-and-mouth disease (FMD) is, arguably, the animal disease with the most devastating global economic impact owing in part, to the severe trade restrictions imposed upon affected countries and regions. South Asia is one of the regions where widespread lineages of the FMDV virus (FMDV) have emerged. Here, we performed an integrative phylogenetic analysis of all FMDV serotypes (A, O and Asia-1) circulating in southern Asia, including viral sequences collected until 2013. Our results describe the occurrence of FMD caused by different serotypes and lineages, focusing in the cycles where a specific lineage predominates within a region for a protracted period and then are rapidly or progressively replaced by an emergent or re-emergent strain that is introduced from an adjacent region. Transmission between the two main regions in southern Asia (the Indian subcontinent and the region comprised by Afghanistan, Iran and Pakistan) has been limited. Results of time divergence estimation of lineages that currently circulate in this region indicate that the most recent common ancestor of endemic lineages are: 1992 [1989-1995] for lineage O/PanAsia; 1997 [1995-1999] for PanAsia2; 2001 [1998-2004] for O/Ind2001; 2001 [2000-2002] for A/Iran-05; 1990 [1988-1991] for A/G-18 (G-VII); 2003 [2000-2006] for Asia-1 Sindh08 and 2002 [1999-2004] for Asia-1 G-VIII. We estimated the mean of the overall substitution rate of the VP1 coding region (substitution/site/year) for serotype O (5.95 × 10 ), serotype A (1.19 × 10 ) and serotype Asia-1 (3.08 × 10 ). The potential factors driving the lineage turnover are discussed. Our results provide insights into the ecological and evolutionary factors driving the emergence of FMDV.

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“…Molecular epidemiological studies of the vp1 gene have shown that these isolates belong to the Asia topotype, which has caused endemic outbreaks in Southeast Asian countries in recent years [15], [16]. These strains continue to evolve and pose a serious threat to the livestock industry worldwide, and to previously FMD-free regions [17], such as South Korea, where this type of the virus was first reported in January 2010.…”

Section: Introductionmentioning

confidence: 99%

Engineering Foot-and-Mouth Disease Viruses with Improved Growth Properties for Vaccine Development

et al. 2013

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BackgroundNo licensed vaccine is currently available against serotype A foot-and-mouth disease (FMD) in China, despite the isolation of A/WH/CHA/09 in 2009, partly because this strain does not replicate well in baby hamster kidney (BHK) cells.Methodology/Principal FindingsA novel plasmid-based reverse genetics system was used to construct a chimeric strain by replacing the P1 gene in the vaccine strain O/CHA/99 with that from the epidemic stain A/WH/CHA/09. The chimeric virus displayed growth kinetics similar to those of O/CHA/99 and was selected for use as a candidate vaccine strain after 12 passages in BHK cells. Cattle were vaccinated with the inactivated vaccine and humoral immune responses were induced in most of the animals on day 7. A challenge infection with A/WH/CHA/09 on day 28 indicated that the group given a 4-µg dose was fully protected and neither developed viremia nor seroconverted to a 3ABC antigen.Conclusions/SignificanceOur data demonstrate that the chimeric virus not only propagates well in BHK cells and has excellent antigenic matching against serotype A FMD, but is also a potential marker vaccine to distinguish infection from vaccination. These results suggest that reverse genetics technology is a useful tool for engineering vaccines for the prevention and control of FMD.

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Genetic characterization of type A foot-and-mouth disease virus 3A region in context of the reemergence of VP359-deletion lineage in India

Cited by 7 publications

References 35 publications

Comparative complete genome analysis of Indian type A foot-and-mouth disease virus field isolates

Comparative complete genome analysis of Indian type A foot-and-mouth disease virus field isolates

Dynamics of widespread foot‐and‐mouth disease virus serotypes A, O and Asia‐1 in southern Asia: A Bayesian phylogenetic perspective

Engineering Foot-and-Mouth Disease Viruses with Improved Growth Properties for Vaccine Development

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