Genetic Control of Lymphomatosis in the Fowl

Cultivation and characterisation of avian lymphocytes with natural killer cell activity

“…The S-13 line was derived from the S-strain (Hutt and Cole, 1947) by selection of chickens homozygous for the B 13 alíele (Schat, unpublished data).…”

Resistance of Strains of Chickens to Marek’s Disease

“…1969;Schmittle andEidson 1968). On the other hand, strain K, which was selected for resistance to lymphomatosis by Hutt and Cole ( 1947 ) , was significantly more susceptible (P < 0.01) than four of nine strains. In contrast to this linding, Cole (1968) Purchase and Biggs (1967) who also found a significantly greater incidence of gonadal lesions in females than males of two strains.…”

“…Strains X, Y, and Z were three commercial egg strains. Strains S and K had been selected for susceptibility and resistance, respectively, to MD (Hutt and Cole 1947) at Cornell University. Great-grandparents of these chicks consisted of 260 females and 30 males derived from hatching eggs received from Corneil University.…”

The development of two white Plymouth Rock lines resistant to Marek's disease by breeding from survivors1

“…In 1926, Pappenheimer et al observed a breed difference in susceptibility to MD, and in 1932 Asmundson and Biely published the first study on the inheritance of resistance to MD. The feasibility of breeding chickens resistant to the disease was also demonstrated decades ago (Hutt and Cole, 1947); at that time natural exposure was employed. Although progress was made, major disadvantages with natural exposure to MD virus (MDV) were the long test period, the unmeasurability of the challenge and the unpredictability of the response.…”