Genetic Control of the Immune Response to Thy‐1 Antigens<sup>1</sup>

Zaleski, Marek; Klein, Jan

doi:10.1111/j.1600-065x.1978.tb00386.x

Cited by 48 publications

(17 citation statements)

References 53 publications

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“…We tested cells from M523 mice for their ability to produce cross-reactive CTL after TNPmodified syngeneic stimulation. The results of these experiments could clarify the relationship of the gene controlling cross-reactive lysis to the one described by Zaleski and Klein (15) and might elucidate the role of H-2K structural genes in the control of CTL specificity. Data presented in Table V show that M523 CTL induced by TNP-modified syngeneic cells do not cross-reactively lyse BALB/c or B10 TNP-modified targets and demonstrate very little lysis of TNP-modified C3H.OL targets which theoretically share identical H-2D end determinants, suggesting that this mutation does not affect the gene(s) described by Schmitt-Verhulst and Shearer (13).…”

Section: M523 Mutation Does Not Affect the Gene(s) Controlling Cross-mentioning

confidence: 87%

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Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

Billings¹,

Burakoff²,

Dorf³

et al. 1978

The Journal of Experimental Medicine

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The ability of cytotoxic T lymphocytes (CTL) induced in vitro to trinitrophenyl (TNP)-modified syngeneic cells to cross-reactively lyse a TNP allogeneic spleen target varies among inbred mouse strains. The cross-reactive CTL phenotype was found to be histocompatibility 2 (H-2) linked and to be dominant in F1 hybrid mice. All strains investigated demonstrated cross-reactivity except for some strains bearing portions of the H-2k haplotype. The gene(s) controlling this response maps to the K and/or I-A region of the H-2 complex. We have termed the immune response (Ir) gene responsible for controlling the specificity of CTL induced to TNP-modified syngeneic cells Ir-X-TNP.

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Section: M523 Mutation Does Not Affect the Gene(s) Controlling Cross-mentioning

confidence: 87%

“…Several other IX genes controlling immune responses to cell surface-associated antigens appear to map close to the Ir-X-TNP gene (13,15). Whether the IX-X-TNP gene codes for a T-cell recognition defect or rather controls CTL responses by restricting cell-to-cell collaboration or by allowing regulatory cells to be produced is unresolved.…”

Section: Discussionmentioning

confidence: 99%

Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

Billings¹,

Burakoff²,

Dorf³

et al. 1978

The Journal of Experimental Medicine

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“…Because previous genetic mapping showed that the H-2Ra mutation occurred in the H-2Kk gene, and that there was no evidence for a second mutation in any of the class I1 genes, we concluded that, as far as the response to Thy-1.1 is concerned, the class I H-2Kk gene behaved as an Ir gene. This conclusion is open to a variety of criticisms which we discuss elsewhere (19). Suffice it to say that if one were to accept certain interpretation of the Ir-gene function, the Ir-like behavior of the H-2K gene-under certain circumstances-would not be surprising.…”

Section: I-ization Of the K Regionmentioning

confidence: 83%

The unity of genes in the Major histocompatibility complex

Klein

1978

Arthritis & Rheumatism

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The major histocompatibility complex (MHC) of the mouse can be genetically divided into several regions specialized to performing specific functions. Thus the class I regions (K and D ) code for antigens that activate effector (killer) T cells, class I1 region (I) for antigens causing T-cell proliferation, and class I11 regions ( 8 ) for complement components. A strong case is made for the theory that the division of labor within the MHC is not absolute. Evidence is presented that class I antigens can sometimes cause as strong T-cell proliferation as class I1 antigens; that class I1 antigens can generate effector T cells; and that class I antigens may be involved in the immune response to some antigens. The fact that different regions can perform similar functions argues for the unity of the MHC genes.

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“…First, it was repeatedly shown [6,9] that, under the conditions employed, both tests, i.e., plaque assay and spot test, are highly specific for the anti-Thy-1 re sponse. The presence of non-Thy-1 antibodies, e.g., anti-H-2 antibodies, can be ruled out in the present experiments, since in all cases recipients and donors shared at least one H-2 haplotype ( H-2h).…”

Section: Discussionmentioning

confidence: 99%

Preliminary Analysis of Primary and Secondary Anti-Thy-1 Responses Elicited by Immunization with Cell-Bound and Cell-Free Antigen

Zaleski¹,

Reichner²,

Albini³

1984

Int Arch Allergy Immunol

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Primary and secondary anti-Thy-1 responses were elicited in C57BL/6Kh and (C57BL/ 6Kh × BALB/cKh)Fι mice by injection of either intact or sonicated Thy-1 disparate thymocytes as the source of the two forms of Thy-1 antigen – cell bound and cell free, respectively. The primary response was characterized by a high number of anti-Thy-1 plaque-forming cells in the spleen and a high titer of serum antibodies that belonged predominantly to the IgM class. The secondary response consisted of a moderate number of plaque-forming cells and a high titer of serum antibodies that belonged to the IgG and IgM classes. Only secondary responses ensued in mice primed and boosted with the same form of antigen, whereas primary and secondary responses developed concomitantly in animals primed with one form and boosted with both forms simultaneously. These data suggested that the two forms of Thy-1 antigen activate in a given responder two discrete subsets of T cells.

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Genetic Control of the Immune Response to Thy‐1 Antigens¹

Cited by 48 publications

References 53 publications

Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

The unity of genes in the Major histocompatibility complex

Preliminary Analysis of Primary and Secondary Anti-Thy-1 Responses Elicited by Immunization with Cell-Bound and Cell-Free Antigen

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Genetic Control of the Immune Response to Thy‐1 Antigens1

Cited by 48 publications

References 53 publications

Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

The unity of genes in the Major histocompatibility complex

Preliminary Analysis of Primary and Secondary Anti-Thy-1 Responses Elicited by Immunization with Cell-Bound and Cell-Free Antigen

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Product

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Genetic Control of the Immune Response to Thy‐1 Antigens¹